Additional PBL Assay Services

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The PBL team has extensive experience and depth of knowledge in cytokine and interferon-related research, as well as in immunological assay development. With our team-based approach and attention to detail, we provide uncompromising quality from a company you can trust. We strive to communicate effectively with our clients by keeping you informed throughout your project and by facilitating direct and open communication channels with our scientific team. As we can custom tailor our services to meet your specific project needs, contact PBL today to discuss how we may be able to help you!

Custom Assay Design & Development

 

PBL assay development services can be tailored to your specific needs. Assays are developed for research use or to a standard which supports subsequent GLP validation.

 

You can be confident that PBL will provide a viable solution that will maximize the data from your samples during a development project. We will work alongside you to define essential steps, reagents required, and identify potential issues before they occur. From proof of principle to technology transfer, our experience will ensure we deliver a robust and sensitive assay solution for your specific application needs.

 

Cell-Based Assay Development

 

Cell-based assay development services offered, but not limited to, include:

  • Custom cytopathic effect, anti-proliferative, and growth promotion assays
  • Development of reporter gene systems or identification of cell lines to monitor activity of the compound of interest
  • Neutralization of bioactivity by antibodies which is relevant to identification of bioactive monoclonal antibodies (MAbs) and monitoring of immunogenicity

Immunoassay Development
 

Custom immunoassays and ELISAs to support:

  • Pharmacokinetic and pharmacodynamic studies
  • Toxicity and immunogenicity studies
  • Direct, sandwich, or competitive ELISA assay development

Assay Optimization Service

 

  • Specificity and cross-reactivity assessment
  • Analytic and dynamic range optimization
  • Reduction of matrix effects (serum, plasma, tissue culture media)
  • Reduction of inter- and intra-assay variability
  • Standard calibration
  • Assay stability assessment
  • Protocol optimization

Technology Transfer
 

Multiple developed assays have been transferred to regulated environments.

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