EMD Millipore (Singulex) Erenna/SMC Assay Services: Ultra-Sensitive Cytokine Testing

Key Features offered by Erenna Single Molecule Counting (SMC) Technology:

  • Enables sub-pg/ml sensitivity for accurate measurement of low abundance biomarkers in serum, plasma or other complex matrices

  • Requires minimal sample dilution with a 4-Log+ dynamic range

  • Provides high precision and reproducible data

  • Extensive analyte menu of over 30 different cytokine assays covering several disease areas

For a detailed overview of the Singulex Erenna cytokine detection technology, click here.

 

For additional information, check out PBL's Ultra-Sensitive Immunoassay Poster and Ultra-Sensitive Cytokine Detection Service Flyer

 

Figure 1. Median levels of IL-1b (Interleukin 1 Beta) in Plasma Samples (Heparin, Citrate and EDTA)

PBL Singulex Erenna shows the ability to measure low levels of IL-1 Beta in Plasma samples (Heparin, Citrate and EDTA)

Interested in our services?

Please include any project requirements or preferences including, for example, (1) number of samples, (2) sample matrix type(s), (3) volume of each sample, and (4) preferred number of replicates (e.g. singlet, duplicate, triplicate).

Available Singulex Immunoassays on Single Molecule Counting (SMC) ErennaTM Instrument:

*The Representative Functional LLOQ is the assay’s Representative Analytical LLOQ corrected for a Recommended Sample Dilution Factor specific to each assay. Both the Representative Calibration Range and Functional LLOQ are often lot-specific.

Assay [Catalog No.]

Species Matrix Representative Calibration Range Representative Functional LLOQ Datasheet
Aβ-40 [03-0145-00]
Amyloid Beta 1-40 High Sensitivity Assay Kit
Human, Mouse, Rat

CSF, Plasma

2.93 – 3,000 pg/mL

CSF: 117.2 pg/mL

P: 23.44 pg/mL

Datasheet
Aβ-42 [03-0146-00]
Amyloid Beta 1-42 High Sensitivity Assay Kit
Human, Mouse, Rat

CSF, Plasma

0.24 – 250 pg/mL

CSF: 19.6 pg/mL

P: 3.92 pg/mL

Datasheet
AKT1 (Ser473) [03-0100-01]
Phospho AKT1 Assay Kit
Human, Mouse, Rat

Lysate

1 – 1,000 pg/mL

Dependent on Cell Line Datasheet
AKT1 (Total) [03-0099-01]
Total Phospho AKT1 Assay Kit
Human, Mouse, Rat

Lysate

0.2 – 200 pg/mL

Dependent on Cell Line Datasheet
BDNF [03-0171-00]
Brain-Derived Neurotrophic Factor High Sensitivity Assay Kit
Human

CSF, Plasma, Serum

0.02 – 100 pg/mL

CSF: 0.04 pg/mL

P: 4 pg/mL

S: 4 pg/mL

Datasheet
cTnI [03-0092-00]
Cardiac Troponin I Assay Kit
Canine, Cynomolgus, Guinea Pig, Human, Rat

Plasma, Serum

0.17 – 600 pg/mL

Not Given

Datasheet
cTnI [03-0154-00]
Cardiac Troponin I Assay Kit
Canine, Cynomolgus, Guinea Pig, Human, Rat

Plasma, Serum

0.17 – 600 pg/mL

0.69 pg/mL

Datasheet
G-CSF [03-0047-00]
Granulocyte Colony-Stimulating Factor Assay Kit
Human

Plasma

0.02 – 20 pg/mL

Not Given Datasheet
GLP-1 (Active) [03-0024-03]
Active Glucagon-Like Peptide 1 Assay Kit
Canine, Human, Mouse, Rat

Plasma

0.05 – 50 pg/mL

Not Given Datasheet
GLP-1 (Total) [03-0025-06]
Total Glucagon-Like Peptide 1 Assay Kit
Canine, Human, Mouse, Rat

Plasma

0.2 – 200 pg/mL

Not Given Datasheet
Glucagon [03-0153-00]
Glucagon High Sensitivity Assay Kit
Human, Mouse, Rat

Plasma

0.2 – 200 pg/mL

7.81 pg/mL Datasheet
GM-CSF [03-0067-00]
Granulocyte Macrophage Colony-Stimulating Factor Assay Kit
Human

Plasma

0.005 – 5 pg/mL

Not Given Datasheet
IFN-γ [03-0049-00]
Inteferon Gamma Assay Kit
Human

Plasma

0.02 – 25 pg/mL

Not Given Datasheet
IL-1α [03-0072-00]
Interleukin 1 Alpha Assay Kit
Human

Plasma, Serum

0.1 – 100 pg/mL

Not Given Datasheet
IL-1α [03-0167-00]
Interleukin 1 Alpha High Sensitivity Assay Kit
Human

Plasma, Serum

0.06 – 60 pg/mL

0.12 pg/mL Datasheet
IL-1β [03-0028-00]
Interleukin 1 Beta Assay Kit
Human

Plasma

0.049 – 50 pg/mL

Not Given Datasheet
IL-1β [03-0160-00]
Interleukin 1 Beta High Sensitivity Assay Kit
Human

Plasma, Serum

0.05 – 50 pg/mL

0.2 pg/mL Datasheet
IL-2 [03-0051-00]
Interleukin 2 Assay Kit
Human

Plasma, Serum

0.05 – 50 pg/mL

Not Given Datasheet
IL-4 [03-0052-00]
Interleukin 4 Assay Kit
Human

Plasma

0.01 – 100 pg/mL

Not Given Datasheet
IL-4 [03-0161-00]
Interleukin 4 High Sensitivity Assay Kit
Human Plasma, Serum

0.01 – 100 pg/mL

0.04 pg/mL Datasheet
IL-5 [03-0053-00]
Interleukin 5 Assay Kit
Human Plasma, Serum

0.98 – 1,000 pg/mL

Not Given Datasheet
IL-5 [03-0168-00]
Interleukin 5 High Sensitivity Assay Kit
Human Plasma, Serum

0.01 – 50 pg/mL

0.04 pg/mL Datasheet
IL-6 [03-0089-01]
Interleukin 6 Assay Kit
Human Plasma

0.01 – 50 pg/mL

Not Given Datasheet
IL-6 [03-0155-00]
Interleukin 6 High Sensitivity Assay Kit
Human Plasma, Serum

0.01 – 50 pg/mL

0.08 pg/mL Datasheet
IL-7 [03-0094-00]
Interleukin 7 Assay Kit
Human Plasma

0.1 – 100 pg/mL

Not Given Datasheet
IL-8/CXCL-8 [03-0055-00]
Interleukin 8 Assay Kit
Human Plasma

0.24 – 250 pg/mL

Not Given Datasheet
IL-10 [03-0056-00]
Interleukin 10 Assay Kit
Human Plasma

0.17 – 400 pg/mL

Not Given Datasheet
IL-10 [03-0176-00]
Interleukin 10 High Sensitivity Assay Kit
Human Plasma, Serum

0.1 – 100 pg/mL

0.1 pg/mL Datasheet
IL-12 [03-0057-00]
Interleukin 12 Assay Kit
Human Plasma, Serum

0.01 – 12.5 pg/mL

Not Given Datasheet
IL-13 [03-0109-02]
Interleukin 13 (v2) Assay Kit
Human Plasma, Serum

0.02 – 100 pg/mL

Not Given Datasheet
IL-13 [03-0156-00]
Interleukin 13 High Sensitivity Assay Kit
Human Plasma, Serum

0.02 – 100 pg/mL

0.04 pg/mL Datasheet
IL-15 [03-0058-00]
Interleukin 15 Assay Kit
Human Plasma, Serum

0.02 – 25 pg/mL

Not Given Datasheet
IL-17A [03-0103-00]
Interleukin 17A (v2) Assay Kit
Human Plasma, Serum

0.01 – 20 pg/mL

Not Given Datasheet
IL-17A [03-0159-00]
Interleukin 17A High Sensitivity Assay Kit
Human Plasma, Serum

0.02 – 60 pg/mL

0.06 pg/mL Datasheet
IL-17A/F [03-0177-00]
Interleukin 17A/F High Sensitivity Assay Kit
Human Plasma, Serum

0.6 – 600 pg/mL

4.68 pg/mL Datasheet
IL-17A/F Heterodimer [03-0119-00]
Interleukin 17A/F Heterodimer (v2) Assay Kit
Human Plasma, Serum

0.3 – 300 pg/mL

Not Given Datasheet
IL-21 [03-0014-07]
Interleukin 21 Assay Kit
Human Plasma, Serum

0.11 – 250 pg/mL

Not Given Datasheet
IL-22 [03-0059-01]
Interleukin 22 Assay Kit
Human Plasma

0.1 – 100 pg/mL

Not Given Datasheet
IL-22 [03-0162-00]
Interleukin 22 High Sensitivity Assay Kit
Human Plasma, Serum

0.05 – 50 pg/mL

0.4 pg/mL Datasheet
IL-23 [03-0112-00]
Interleukin 23 Assay Kit
Human Plasma, Serum

0.1 – 100 pg/mL

Not Given Datasheet
IL-23 [03-0157-00]
Interleukin 23 High Sensitivity Assay Kit
Human Plasma, Serum

0.05 – 50 pg/mL

0.1 pg/mL Datasheet
KIM-1 [03-0118-00]
Kidney Injury Molecule 1 Assay Kit
Human Plasma, Serum, Urine

1 – 1,000 pg/mL

Not Given Datasheet
TNF-α [03-0088-00]
Tumor Necrosis Factor Alpha Assay Kit
Human Plasma

0.049 – 50 pg/mL

Not Given Datasheet
TNF-α [03-0163-00]
Tumor Necrosis Factor Alpha High Sensitivity Assay Kit
Human Plasma, Serum

0.05 – 50 pg/mL

0.2 pg/mL Datasheet
TNF-α [03-0108-00]
Tumor Necrosis Factor Alpha Assay Kit
Mouse Serum

0.05 – 50 pg/mL

Not Given Datasheet
VEGF [03-0068-00]
Vascular Endothelial Growth Factor Assay Kit
Human Plasma

0.1 – 100 pg/mL

Not Given Datasheet
VEGF-A [03-0180-00]
Vascular Endothelial Growth Factor A High Sensitivity Assay Kit
Human Plasma, Serum

0.1 – 100 pg/mL

0.8 pg/mL Datasheet

PBL Assay Science's ultra-sensitive cytokine detection services are powered by the Erenna single-molecule counting (SMC) technology in conjunction with robust microparticle (MP) based sandwich immunoassays that enables accurate, high-precision baseline quantification of low-abundance analytes at or below sub-picogram concentrations.

 

The background reduction methodology of this detection service extends the linear dynamic range to over 4 logs allowing scientists to measure biomarkers in many disease states at unprecedented levels. In addition to minimal sample dilution, robust and reproducible data make this detection service a great tool that can help scientists come to an increased understanding of analyte activities in biological responses. 

 

Powered by the Erenna® Immunoassay System, EMD Millipore Inc., Burlington, MA, USA.

 

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