Neutralizing Antibody Assay Service

Service Features:

  • Accurate determination of sample inhibitory effect on the biological activity of cytokines such as interferons (IFNs)

  • Neutralizing activity measurement performed in a cell based assay format using serum, plasma, cell culture media, or tissue culture media samples may be used as an anti-drug antibody (ADA) assay

  • Neutralization assay results reported in graphical format together with raw data

Figure 1. Representative neutralization curves of a sample of two monoclonal antibodies to interferon in a cytopathic effect inhibition (CPE) assay to determine neutralization titer. One neutralization unit is the amount of antiserum or antibody (NAb) required to neutralize one unit of human interferon to a 50% endpoint in the bioassay. The units are determined with respect to the international reference standard for interferon.

Neutralizing Antibodies Assay Service

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Please include any project requirements or preferences including, for example, (1) number of samples, (2) sample matrix type(s), (3) volume of each sample, and (4) preferred number of replicates (e.g. singlet, duplicate, triplicate).

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