Technical Information

Signaling in the Type I Interferon Antiviral Innate Immune Response

Type I IFN proteins bind to the type I IFN receptor and activate Janus kinase–signal transducer and activator of transcription (Jak-STAT) signaling and formation of the trimeric transcription factor complex ISGF3, which promotes expression of antiviral effector proteins as well as proteins that positively and negatively modulate subsequent signaling. This poster highlights common and distinct components of these pathways that together lead to a highly orchestrated innate immune response to viral infection.

 

Mouse Interferon Alpha Nomenclature

van Pesch et al. 2004 Hardy et al. 2004 Alternate Sequences
Name (Catalog No.) Accession Activity Name Accession    

Human Interferon Alpha Nomenclature

Catalog No. Nomenclature Alias Gene Molecular Weight Theoretical pI
11100-1 αA α2a IFNA2 19241 5.99
11105-1 α2 α2b IFNA2 19269 5.99
11115-1 αB2

White Paper: Utility and Application of the VeriKine Cynomolgus/Rhesus Interferon Alpha Serum ELISA

Content:

  • Non-human primate in pre-clinical research
  • IFN-α and TLR therapeutics
  • IFN-α and hepatitis infections
  • IFN-α and rheumatoid arthritis
  • Benefits of the VeriKine Cynomolgus/Rhesus IFN-α ELISA

Abstract

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