Technical Information

Introduction to Interferon

Interferons (IFNs) are a family of mammalian cytokines initially characterized by their ability to inhibit viral infection. In addition to their antiviral properties, IFNs have also been shown to exhibit antiproliferative, immunomodulatory, and many other activities.

 

Introduction to ELISA

Enzyme Linked Immunosorbent Assay (ELISA) is a powerful technique for detection and quantitation of biological substances such as protein, peptides, antibodies, and hormones. By combining the specificity of antibodies with the sensitivity of simple enzyme assay, ELISA can provide a quick and useful measurement of the concentration of an unknown antigen or antibody.

 

Cross-Regulation of Signaling Pathways by Interferon Gamma

Interferon-γ (IFN-γ) is an important mediator of immunity and inflammation that utilizes the Janus kinase (JAK)-signal transducers and activators of transcription (STAT) signaling pathway. Many key IFN-γ functions are mediated by cross-regulation of cellular responses to other cytokines and inflammatory factors. This cross-regulation has important functional implications for macrophage activation, cytokine production, inflammation, tissue remodeling, and T cell differentiation, and for autoimmune diseases.

 

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