Assay Design and Development Services

       

PBL Assay Science provides efficient and cost-effective assay design and development services. You can be confident that we will provide a viable solution that will maximize the data from your samples during a development project. We will work alongside you to define essential steps, reagents required and identify potential issues before they occur. From proof of principle to technology transfer, our experience in immunological research and assay development will ensure we will deliver a robust and sensitive assay solution for your specific application needs.

     

Interested in one of our services?

Contact us:

W: online form

E: assayservices@pblassaysci.com

P: 1-877-PBL-8881

F: 1-732-777-9141

 
         

Cell-based Assay Development Service:

  • Custom cytopathic effect, anti-proliferative and growth promotion assays
  • Development of reporter gene systems or identification of cell lines to monitor activity of the compound of interest
  • Neutralization of bioactivity by antibodies relevant to identification of bioactive monoclonal antibodies (MAbs) and monitoring of immunogenicity

Figure 1. Titration of different IFNs on a cell line stably transfected with an ISG promoter-luciferase gene construct. Cells were exposed to varying concentrations of IFNs for 18 hours followed by measurement of induced luciferase enzyme activity.

         

Figure 1

   
         

Immunoassay Development Service:

  • Pharmacokinetic (PK) and pharmacodynamic (PD) studies
  • Toxicity and immunogenicity studies
  • Direct, sandwich or competitive ELISA assay development
         

 

   
         

Assay Optimization Service:

  • Specificity and cross-reactivity assessment
  • Analytic and dynamic range optimization
  • Reduction of matrix effects (serum, plasma, tissue culture media)
  • Reduction of inter- and intra-assay variability
  • Standard calibration
  • Assay stability assessment
  • Protocol optimization
         

 

   

 

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