Simoa Assay Services: Ultra-Sensitive Biomarker Testing

       

Advantages of Simoa Assay Services:

  • Utilizing Single Molecule Array technology to deliver femtogram per milliliter (fg/ml) level sensitivity for measurement of low-abundance biomarkers in serum, plasma and other matrices

  • Unique immunoassay technology provides robust detection for various single analytes and select multiplex panel options 

  • High precision service offers accurate and reproducible data with < 10% inter- and intra-assay CVs

  • Over 50 analytes available including IL-17A, TNF-alpha, IL-23, IP-10, TRAIL, IL-6, IL-10 and IL-12p70

For an overview of the ultra-sensitive biomarker detection technology, click here.

 

For additional information, please see the Ultra-Sensitive Biomarker Services Flyer

     

Interested in our assay services?

 

Contact us:

W: online form

E: assayservices@pblassaysci.com

P: 1-877-PBL-8881

F: 1-732-777-9141

 

 

Available Human Simoa Immunoassays:

3-Plex A
TNF-α, IL-6, IL-10
3-Plex B
TNF-α, IL-6, IL-17A
Neurology 3-Plex A
Aβ-40, Aβ-42, Tau
α-Synuclein
Alpha-Synuclein Assay
Aβ-40
Amyloid Beta-40 Assay
Aβ-42
Amyloid Beta-42 Assay
BDNF
Brain Derived Neurotrophic Factor Assay
c-MET
c-MET Assay
C-peptide
Connecting Peptide Assay
CA-125
CA-125 Assay
Cathepsin S
Cathepsin S Assay
Eotaxin
Eotaxin Assay
GFAP™
Glial Fibrillary Acidic Protein Assay
G-CSF
Granulocyte Colony Stimulating Factor Assay
GM-CSF
Granulocyte Macrophage Colony Stimulating Factor Assay
IFN-γ
Interferon Gamma Assay
IL-1α
Interleukin 1 Alpha Assay
IL-1β
Interleukin 1 Beta Assay
IL-2
Interleukin 2 Assay
IL-3
Interleukin 3 Assay
IL-4
Interleukin 4 Assay
IL-5
Interleukin 5 Assay
IL-6
Interleukin 6 Assay
IL-7
Interleukin 7 Assay
IL-8
Interleukin 8 Assay
IL-10
Interleukin 10 Assay
IL-12p40/IL-23
Interleukin 12, p40 Assay
IL-12p70
Interleukin 12, p70 Assay
IL-13
Interleukin 13 Assay
IL-15
Interleukin 15 Assay
IL-16
Interleukin 16 Assay
IL-17A
Interleukin 17A Assay
IL-22
Interleukin 22 Assay
IL-23
Interleukin 23 Assay
IL-28A
Interleukin 28A Assay
IL-33
Interleukin 33 Assay
IL-36β
Interleukin 36 Beta Assay
IP-10
Interferon Gamma Inducible Protein 10 Assay
Leptin
Leptin Assay
LIF
Leukemia Inhibitory Factor Assay
MCP-1
Monocyte Chemoattractant Protein-1 Assay
NF-LIGHT®
Neurofilament Light Assay
NSE
Neuron-Specific Enolase Assay
p24
Gag Protein p24 Assay
p-Tau231
Phospho-Tau231 Assay
PIGF
Placental Growth Factor Assay
PSA
Prostate Specific Antigen Assay
Tau
Total Tau Assay
TDP43
TAR DNA Binding Protein Assay
TGF-α
Transforming Growth Factor Alpha Assay
TGF-β
Transforming Growth Factor Beta Assay
TNF-α
Tumor Necrosis Factor Alpha Assay
TNF-β
Tumor Necrosis Factor Beta Assay
TRAIL
TNF-related Apoptosis-Inducing Ligand Assay
Troponin-I
Cardiac Troponin-I (cTnI) Assay
UCH-L1™
Ubiquitin Carboxyl-Terminal Hydrolase L1 Assay
VEGF
Vascular Endothelial Growth Factor Assay
     

 

 

Available Mouse Simoa Immunoassays:

IL-6
Interleukin 6 Assay
IL-17A
Interleukin 17A Assay
IL-17A/F
Interleukin 17A/F Assay
IL-17F
Interleukin 17F Assay
IL-22
Interleukin 22 Assay
IL-23
Interleukin 23 Assay
Tau
Tau Assay
TNF-α
Tumor Necrosis Factor Alpha Assay
       

 

           

PBL's Ultrasensitive Biomarker Testing Assay Services take advantage of the benefits of Single Molecule Array (Simoa) technology. This approach traps a single bead in low femtoliter-sized wells to allow “digital” measurement of each bead for the presence of analyte in a sandwich immunoassay. The enzymatic amplification of analyte binding vents on single beads in single wells yields low background signals, and can increase assay sensitivities up to several orders of magnitude over conventional assays. Biomarker assays run on this platform frequently exhibit sensitivities in the low to mid fg/ml range.

 

In combination with the markedly heightened sensitivities of these assays, the instrument’s capacity for digital measurement at low concentrations of target analyte and analog measurement at higher analyte concentrations ensures accuracy and precision across a wide dynamic range (> 4 logs) minimizing sample volume requirements and the need for multiple dilutions. Allowing quantification of biomarkers at unprecedented levels in serum, plasma, and additional matrices, PBL’s Simoa-based Assay Services yield robust and reproducible data enabling scientists to attain a better understanding of the contributions of difficult to measure analytes to biological and pathological responses.

 

Powered by SimoaTM (Single Molecule Array) Technology, Quanterix, Lexington, MA, USA.

NF-light® is a registered trademark of Uman Diagnostics, Umeå Sweden.

             

Technology Summary

Digital measurements are independent of intensity and simply rely on a signal/no signal readout on individual micro beads.

(Please click image to enlarge.)

     

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