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IFN beta |
All interferon beta products and related technical information (e.g. technical notes) |
Human IFN beta |
All human interferon products related technical information (e.g. technical notes) |
IL-2 |
All products contain the term “IL-2”, including IL-23 |
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Type III Interferons (IFNs), interferon lambda 1 (IL-29), interferon lambda 2 (IL-28A), and interferon lambda 3 (IL-28B) are recently identified class II cytokine receptor ligands that are members of the Interleukin 10 (IL-10) family. The expression of Type III IFNs is induced by virus infection or double-stranded RNA (dsRNA). All three IFN-λ proteins exert bioactivities that overlap those of type I IFNs such as IFN-α and IFN-β, including antiviral activity and up-regulation of MHC class I antigen expression. They signal through a heterodimeric receptor complex that is composed of the IL-10 receptor β (IL-10Rβ) and a novel IL-28 receptor α (IL-28 Rα, also known as IFN-λ R1). Ligand binding to this receptor leads to Jak-STAT signaling.
Functionally, type III IFNs display similar properties to type I IFNs. They have been shown to function by signaling through the JAK-STAT pathway upregulating the expression of genes involved in controlling viral replication and cellular proliferation. Recent gene knockout studies suggest that the Type III IFNs signaling pathway may have been conserved to combat pathogens that target type I IFNs. Research on the regulation of type III IFNs may result in a better understanding of the host response mechanism during viral infection.
Reagents |
Assay Kits |
Anti-Human IFN-λ2 antibody |
DIY Human IFN Lambda 2/3 (IL28A/B) ELISA |
Anti-Human IFN-λ3 antibody |
DIY Human IFN Lambda 1/2/3 (IL29/28A/28B) ELISA |
Anti-Human IFN-λ Receptor 1 (IFNLR1) antibody |
Human IFN 9-Plex ELISA |
Human IL-28A/IFN Lambda 2, Human Cell-Expressed Protein |
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Human IL-29/IFN Lambda 1, Human Cell-Expressed Protein |
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Human IL-28B/IFN Lambda 3, Human Cell-Expressed Protein |
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Human IL-28A/IFN Lambda 2, mammalian cell expressed Protein, carrier-free |
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Human IL-29/IFN Lambda 1, mammalian cell expressed Protein, carrier-free |
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PBL works hand in hand with researchers to help solve difficult assay development and protein quantification problems. Known as a trusted source for high quality, high sensitivity ELISAs as well as interferon proteins and antibodies, PBL employs state-of-the-art technology in conducting assay services and manufacturing world-class products for scientists around the globe. Let us help you solve your most difficult problems... read more
Quick Search
PBL’s improved site search function is defaulted to an exact match.
Search Term Results |
|
IFN beta |
All interferon beta products and related technical information (e.g. technical notes) |
Human IFN beta |
All human interferon products related technical information (e.g. technical notes) |
IL-2 |
All products contain the term “IL-2”, including IL-23 |
IL 2 |
All products contain the term “IL 2”, including IL-23 |
Erythropoietin |
All EPO products and technical information |
Eryth |
All EPO products and technical information |
The results are displayed in best match products grouped in the following product category filters:
Each filter contains sub-categories for further narrowing of your search results
Other web content such as technical notes that contain the Search Term can be displayed by checking the box next to the corresponding filter on the left side of the Search Results Page.