Universal Type I IFN Alpha

Product Features: 
  • Human Type I IFN-Alpha protein hybrid exhibiting activity across multiple species
  • Crucial for cross-species comparative studies in virology, immune modulation and more
  • Essential to in vivo or in vitro studies where the species-relevant Type I IFN alpha is unavailable or performs inconsistently

Ordering

Catalog No. Pack Size Price Quantity
11200-1

1 x 105 units

$355.00
11200-2

1 x 106 units

$615.00

Specifications

Formulation Supplied frozen in phosphate-buffered saline (PBS) containing 0.1% Bovine Serum Albumin (BSA)
Molecular Weight 19.4 kDa
Source Construct described in Rehberg, E., (1982) J. Biol. Chem. 257: 11497 derived from E.coli
Purity > 95% by SDS-PAGE stained by Coomassie Blue
Endotoxin level < 1 EU/μg
Bioactivity Measured using a cytopathic inhibition assay on Bovine Kidney Cells (MDBK) with Vesicular Stomatis Virus (VSV); human lung carcinoma cell line A549 with encephalomyocarditis virus (EMCV); Mouse (L929) cells with EMCV
Storage For retention of full activity store at -70 ºC or below and avoid repeated freeze-thaw cycles
Synonyms Hu-IFN-αA/D[Bg/II], Type I Interferon Alpha Hybrid, Universal Type I Interferon Alpha, Type I IFN Alpha, Cross Species IFN Alpha, A/D-BgI II, Type I Interferon Protein, Type I IFN Alpha
Accession Number N/A

Tech Info / Data

Image depicting the Antiviral Activities of PBL's Universal Type I Interferon and Mouse Interferon Alpha A on Mouse Cells as determined in an L929/EMCV CPE assay
Background: 

Universal Type I IFN Alpha is an unique hybrid interferon constructed from recombinant human interferons alpha A and alpha D (Human IFN Alpha A/D [BglII]). Activity has been observed on many mammalian cells, including human, monkey, mouse, bovine, rat, cat, pig, rabbit, guinea pig or hamster. This product is useful for cross-species testing with interferon or for species where autologous interferon is not available.  

Citations

Comparison of Activity of Universal Type I IFN, Human IFN Alpha 2A and Mouse IFN Alpha A

Image depicting the Specific Activities of PBL's Mouse Interferon Alpha A, Human Interferon Alpha 2a, and Universal Type I Interferon as determined in A549/EMCV CPE and L929/EMCV CPE assays

Specific activity of the three IFNs was determined in an A549/EMCV CPE assay(top panel) and an L929/EMCV CPE assay (bottom panel). Both Universal Type I IFN and Human IFN Alpha 2A proteins are potent on human cells while the Mouse IFN Alpha A demonstrated little activity on these cells. Universal Type I IFN and the Mouse IFN Alpha A proteins are potent on mouse cells while the Human IFN Alpha 2A exhibits little activity

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