Quick Search
PBL’s improved site search function is defaulted to an exact match.
Search Term Results |
|
IFN beta |
All interferon beta products and related technical information (e.g. technical notes) |
Human IFN beta |
All human interferon products related technical information (e.g. technical notes) |
IL-2 |
All products contain the term “IL-2”, including IL-23 |
IL 2 |
All products contain the term “IL 2”, including IL-23 |
Erythropoietin |
All EPO products and technical information |
Eryth |
All EPO products and technical information |
The results are displayed in best match products grouped in the following product category filters:
Each filter contains sub-categories for further narrowing of your search results
Other web content such as technical notes that contain the Search Term can be displayed by checking the box next to the corresponding filter on the left side of the Search Results Page.
Interferon alpha (IFN-α) subtypes have long been understood to have differing activities in a variety of assay systems. In order to better understand the determined the binding to isolated IFNAR1 and IFNAR2 extracellular domains by surface plasmon resonance. We observed a 10-fold difference in binding to IFNAR1 with IFN-α8 binding tightest and IFN-α17 binding weakest. Binding to IFNAR2 varied by nearly 100-fold with IFN-α10 binding tightest and IFN-α1 binding weakest. IFN bioactivity was determined by protection against Encephalomyocarditis virus on A549 and OVCAR-3 cells. Vesicular stomatitis virus on A549 and WISH cells, and antiproliferative activity on WISH and OVCAR-3 cells. In general, the binding related well to activity in these systems with some exceptions. IFN-α16 and IFN-α14 generally exhibited potent antiproliferative activity but not antiviral activity. Other subtypes, such as IFN-α8 and IFN-α10, were highly potent in some systems but not in others. A variety of mathematical models were tested to predict activity from binding, and several gave reasonable fit to the data with the most frequent exceptions being IFN-α6 and IFN-α7. These results suggest that while binding is the primary driver of activity, additional variables will need to be considered to explain differences in activity based on factors, such as cell type, challenge virus, and assay format. (Click download for a PDF of the image below)
Find your lot-specific Certificate of Analysis here!
Finding the right biomarker detection service to meet your project needs just got easier...
Sign up for our email list to be kept up-to-date on the latest product releases and company news!
Quick Search
PBL’s improved site search function is defaulted to an exact match.
Search Term Results |
|
IFN beta |
All interferon beta products and related technical information (e.g. technical notes) |
Human IFN beta |
All human interferon products related technical information (e.g. technical notes) |
IL-2 |
All products contain the term “IL-2”, including IL-23 |
IL 2 |
All products contain the term “IL 2”, including IL-23 |
Erythropoietin |
All EPO products and technical information |
Eryth |
All EPO products and technical information |
The results are displayed in best match products grouped in the following product category filters:
Each filter contains sub-categories for further narrowing of your search results
Other web content such as technical notes that contain the Search Term can be displayed by checking the box next to the corresponding filter on the left side of the Search Results Page.