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IFN beta |
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In recent years, the study of Systemic Lupus Erythematosus (SLE) patients has revealed a central role for Interferon alpha (IFN-α) in disease pathogenesis. Furthermore, endogenous nucleic acids and immune complexes (IC) activate Toll-Like Receptors (TLRs) and provide an amplification loop for Type I IFN production by plasmacytoid dendritic cells (pDCs) and for B cell activation in SLE. Indeed, a series of host factors have been recently described that modify self nucleic acids to gain entrance into endosomal compartments within pDCs, where they activate interferogenic TLR signaling. The unabated production of IFN-α induces the transcription of molecules that further contribute to amplify this pathogenic loop. Polymorphisms in genes controlling Type I IFN production or its downstream signaling pathway, such as IRF5, have been recently reported as conferring genetic susceptibility to SLE.(Click download a PDF of the image below)
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Quick Search
PBL’s improved site search function is defaulted to an exact match.
Search Term Results |
|
IFN beta |
All interferon beta products and related technical information (e.g. technical notes) |
Human IFN beta |
All human interferon products related technical information (e.g. technical notes) |
IL-2 |
All products contain the term “IL-2”, including IL-23 |
IL 2 |
All products contain the term “IL 2”, including IL-23 |
Erythropoietin |
All EPO products and technical information |
Eryth |
All EPO products and technical information |
The results are displayed in best match products grouped in the following product category filters:
Each filter contains sub-categories for further narrowing of your search results
Other web content such as technical notes that contain the Search Term can be displayed by checking the box next to the corresponding filter on the left side of the Search Results Page.