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Interferon Beta (IFN-β) was approved to treat relapsing forms of multiple sclerosis in 1993, and there is now abundant evidence that treatment benefits many patients, with an extremely strong safety record. This development represents a solid victory, as IFN-β is the first medication, in the 150 years since multiple sclerosis was described, to modify the natural history of disease favorably. However, there are still unmet medical needs: studies show a broad spectrum of individual responses to IFN-β, from marked benefit to possible deleterious effects; no definite advancement toward combination therapy has been made; and no biomarkers for therapeutic effects have been identified, beyond neutralizing antibodies in a subset of patients. Elucidating molecular mechanisms of IFN-β action in multiple sclerosis would accelerate progress and lead to a new generation of treatment strategies. Recent findings suggest that IFN-β works on several levels to inhibit the multiple sclerosis disease process; proposed mechanisms include inhibiting cell trafficking to the inflamed CNS, inhibiting antigen presentation, and immunomodulation of the TH17 response.(Click download for a PDF of the image below)
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Quick Search
PBL’s improved site search function is defaulted to an exact match.
Search Term Results |
|
IFN beta |
All interferon beta products and related technical information (e.g. technical notes) |
Human IFN beta |
All human interferon products related technical information (e.g. technical notes) |
IL-2 |
All products contain the term “IL-2”, including IL-23 |
IL 2 |
All products contain the term “IL 2”, including IL-23 |
Erythropoietin |
All EPO products and technical information |
Eryth |
All EPO products and technical information |
The results are displayed in best match products grouped in the following product category filters:
Each filter contains sub-categories for further narrowing of your search results
Other web content such as technical notes that contain the Search Term can be displayed by checking the box next to the corresponding filter on the left side of the Search Results Page.