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IFN beta |
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Although non-human primates (Cynomolgus and Rhesus macaques) are used as important pre-clinical models for testing the safety and efficacy of immunomodulatory agents, such as Toll-Like Receptor (TLR) agonists and antagonists, in a variety of diseases, research is currently hindered by the limited availability of reagents for sensitively detecting interferon-alpha (IFN-α) production in these species. IFN-α is produced by many cell types, including plasmacytoid dendritic cells and macrophages, in response to TLR ligation by bacterial and viral components, and plays pivotal roles in both protective and pathologic immunity. Clinically, maintenance of serum IFN-α levels within a range that is advantageous for limiting viral infections, while simultaneously avoiding the onset of autoimmunity, is crucial. As an example, for autoimmune diseases such as rheumatoid arthritis (RA), antagonists to TLRs 7 and 9 are being developed as novel therapeutics to dampen excessive IFN-α production. In contrast, TLR 7 and 9 agonists are being evaluated for their ability to induce IFN-α and enhance protective immunity against Hepatitis C viral infection. However, both of these strategies necessitate carefully monitoring of IFN-α levels to protect against the development of immunocompromise or detrimental side effects. Use of pre-clinical macaque models therefore affords the unique opportunity to test novel therapeutics for efficacy, potency, safety, toxicology, and off-target side effects prior to beginning Phase I trials in humans. In the absence of a rapid, reliable method for detecting IFN-α in macaque samples, researchers are forced to use labor- and time-intensive biological activity assays, resulting in increased project costs and lengthened evaluation periods. In response to these needs, PBL has recently developed a simple, sensitive sandwich ELISA that accurately detects bioactive levels of macaque and other non-human primate IFN-α. Potential applications of the VeriKine Non-Human Primate Serum ELISA kit (catalog # 46100-1) will be discussed.
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PBL works hand in hand with researchers to help solve difficult assay development and protein quantification problems. Known as a trusted source for high quality, high sensitivity ELISAs as well as interferon proteins and antibodies, PBL employs state-of-the-art technology in conducting assay services and manufacturing world-class products for scientists around the globe. Let us help you solve your most difficult problems... read more
Quick Search
PBL’s improved site search function is defaulted to an exact match.
Search Term Results |
|
IFN beta |
All interferon beta products and related technical information (e.g. technical notes) |
Human IFN beta |
All human interferon products related technical information (e.g. technical notes) |
IL-2 |
All products contain the term “IL-2”, including IL-23 |
IL 2 |
All products contain the term “IL 2”, including IL-23 |
Erythropoietin |
All EPO products and technical information |
Eryth |
All EPO products and technical information |
The results are displayed in best match products grouped in the following product category filters:
Each filter contains sub-categories for further narrowing of your search results
Other web content such as technical notes that contain the Search Term can be displayed by checking the box next to the corresponding filter on the left side of the Search Results Page.