Meso Scale Discovery Assay Services: MSD-ECL Assays

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Advantages of Meso Scale Discovery Assay Services:

  • Ability to target low analyte levels in small sample volumes empowered by the Meso Scale Discovery® Electrochemiluminesence (MSD-ECL) technology
  • Measure both high and low abundance analytes (normal and elevated levels) within the same sample with a 5-Log+ dynamic range
  • Patterned arrays and parallel biological processing offer optimal multiplex functionality
  • Robust matrix tolerance including serum, plasma, and tissue culture media (TCM), as well as various complex biological matrices
  • Quantify human, mouse, rat, and non-human primate analytes

PBL utilizes MSD's validated assay kits (V-Plex) to quantify up to 54 analytes within a single sample. This enables simultaneous comparison of the expression of pertinent cytokines, chemokines, and other biomarkers in samples from diseased versus normal subjects at different periods of time.

 

Over 180 fit-for-purpose singleplex and multiplex panels are available through PBL's MSD assay services. Below is a sampling of the V-Plex panels available. Please contact us for information on additional analytes available for human, or analyte panels available for other species.

 

Human IL-3 standard curve on MSD platform

For additional information, please see the MSD-ECL Protein Detection Service Flyer.

 

Interested in our services?

Selected MSD Multiplex Panels

General Category MSD V-Plex Panel Analytes

Human Cytokine & Chemokine Panels
 

 V-Plex Cytokine Panel 1, 10-Plex

GM-CSF, IL-1α, IL-5, IL-7, IL-12/IL-23p40, IL-15, IL-16, IL-17A, TNF-β, VEGF-A
V-Plex Proinflammatory Panel 1, 10-Plex

IFN-γ, IL-1β, IL-2, IL-4, IL-6, IL-8, IL-10, IL-12p70, IL-13, TNF-α
V-Plex Chemokine Panel 1, 11-Plex

Eotaxin, Eotaxin-3, IL-8 (HA), IL-8, IP-10, MCP-1, MCP-4, MDC, MIP-1α, MIP-1β, TARC
V-Plex Th17 Panel 1, 7-Plex

IL-17A, IL-21, IL-22, IL-23, IL-27, IL-31, MIP-3α
V-Plex Human Cytokine, 30-Plex

Eotaxin, Eotaxin-3, GM-CSF, IFN-γ, IL-1α, IL-1β, IL-2, IL-4, IL-5, IL-6, IL-7, IL-8, IL-8 (HA), IL-10, IL-12/IL-23p40, IL-12p70, IL-13, IL-15, IL-16, IL-17A, IP-10, MCP-1, MCP-4, MDC, MIP-1α, MIP-1β, TARC, TNF-α, TNF-β, VEGF-A
V-Plex Human Cytokine, 36-Plex

Cytokines in 30-Plex plus IL-21, IL-22, IL-23, IL-27, IL-31, MIP-3α
V-Plex Human Cytokine, 44-Plex

Cytokines in 36-Plex plus IL-1RA, IL-3, IL-9, IL-17A/F, IL-17B, IL-17C, IL-17D, TSLP

Human Biomarker Panels

 V-Plex Human Biomarker Panel, 40-Plex

CRP, Eotaxin, Eotaxin-3, GM-CSF, FGF (basic), VEGFR-1/Flt-1, ICAM-1, IFN-γ, IL-1α, IL-1β, IL-2, IL-4, IL-5, IL-6, IL-7, IL-8, IL-8 (HA), IL-10, IL-12/IL-23p40, IL-12p70, IL-13, IL-15, IL-16, IL-17A, IP-10, MCP-1, MCP-4, MDC, MIP-1α, MIP-1β, PlGF, SAA, TARC, Tie-2,  TNF-α, TNF-β, VCAM-1, VEGF-A, VEGF-C, VEGF-D

 

V-Plex Human Biomarker Panel, 46-Plex

Cytokines in 40-Plex plus IL-21, IL-22, IL-23, IL-27, IL-31, MIP-3α

Human Neurology & Alzheimer's Disease Panels

V-Plex Aβ Peptide Panel 1 (6E10) Kit

(Amyloid peptides) Aβ38, Aβ40, Aβ42

 

V-Plex Aβ Peptide Panel 1 (4GB) Kit

(Amyloid peptides) Aβ38, Aβ40, Aβ42

 

V-Plex Human Neuroinflammation Panel 1,

37-Plex

CRP, Eotaxin, Eotaxin-3, FGF (basic), VEGFR-1/Flt-1, ICAM-1, IFN-γ, IL-1α, IL-1β, IL-2, IL-4, IL-5, IL-6, IL-7, IL-8, IL-10, IL-12/IL-12p40, IL-13, IL-15, IL-16, IL-17A, IP-10, MCP-1, MCP-4, MDC, MIP-1α, MIP-1β, PIGF, SAA, TARC, Tie-2, TNF-α, TNF-β, VCAM-1, VEGF-A, VEGF-C, VEGF-D 

Mouse Cytokine Panel

V-Plex Mouse Cytokine Panel, 29-Plex

IFN-γ, IL-1β, IL-2, IL-4, IL-5, IL-6, IL-9, IL-10, IL-12p70, IL-15, IL-16, IL-17A, IL-17C, IL-17E/IL-25, IL-17F, IL-21, IL-22, IL-23, IL-27p28/IL-30, IL-31, IL-33, IP-10, KC/GRO, MCP-1, MIP-1α, MIP-2, MIP-3α, TNF-α

Rat Cytokine Panel

V-Plex Proinflammatory Panel 2 Rat Kit

IFN-γ, IL-4, IL-5, IL-6, IL-10, IL-13, KC/GRO, TNF-α

Non-Human Primate Cytokines & Chemokines Panel

V-Plex Cytokine 24-Plex NHP Kit

Eotaxin-3, IFN-γ, IL-1β, IL-2, IL-5, IL-6, IL-7, IL-8, IL-8(HA), IL-10, IL-12/IL-23p40, IL-15, IL-16, IL-17A, IP-10, GM-CSF, MCP-1, MCP-4, MCD, MIP-1α, MIP-1β, TARC, TNF-α, VEGF-A

 

Broad Range of Applications:

 

The unique detection technology provided by the MSD platform utilizes SULFO-TAG™ labels which emit light upon electrochemical stimulation. The intensity of light generated is captured via CCD camera and pixel intensities quantified. This system provides the basis for achieving measurement of a several log range of protein expression levels in a variety of matrices that cover a broad range of analytes, in normal and disease samples, as well as applications.

 

  • Cytokines & Chemokines
  • Cardiac Biomarkers
  • Immunogenicity
  • Immunology
  • Inflammation
  • Intracellular signaling
  • Metabolic
  • Neurodegeneration
  • Oncology and Cancer
  • Toxicity
  • ...and more

 

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