Skip to main content

Human Type 1 IFN Neutralizing Antibody Mixture

Hero Region

Human Type 1 IFN Neutralizing Antibody Mixture

Catalog Number: 39000

Highly recommended unconjugated mixture of MAbs and PAbs directed against human Type 1 IFN receptor and several Type 1 IFNs. Effectively neutralizes biological activity of human IFN-Alpha, IFN-Beta, IFN-Omega, IFN-Kappa, and IFN-Epsilon.

$700.00

Pack Size
Product Info

Specificity

Blocks biological activity of human Type I interferons (alpha, beta, omega, kappa, epsilon)


No cross-reactivity observed with the following:

  • Human IFN-Gamma, lFN-Lambda 1, IFN-Lambda 2, IFN-Lambda 3
    • Mouse IFN-Alpha, IFN-Beta, IFN-Gamma
Tested Application
  • Neutralization

 

Improves neutralization of multiple Type I IFNs often found in complex samples by employing a broadly neutralizing custom antibody cocktail.

Specifications

Formulation Supplied frozen in phosphate-buffered saline (PBS)
Purification A combination of Protein G affinity chromatography and other conventional chromatographical methods.
Endotoxin level < 1 EU/μg
Bioactivity Encephalomyocarditis Virus (EMCV) was used to challenge A549 cells which were incubated with a constant concentration of the antibody mixture and the titrated interferon.
Storage For retention of full activity store at -70°C or below and avoid repeated freeze/thaw cycles
Synonyms Type I interferon, Type I IFN, Neutralizing, Neutralization, Type I Interferon Receptor, Antibody Cocktail

Citations

7 Citations

 

  1. Tabtieng, T. et al., (2022), "Caspase-Mediated Regulation and Cellular Heterogeneity of the cGAS/STING Pathway in Kaposi's Sarcoma-Associated Herpesvirus Infection", mBio, e:0244622, PMID: 36255240, DOI: 10.1128/mbio.02446-22 (link)

  2. Tsuji, S. et al., (2022), "SARS-CoV-2 infection triggers paracrine senescence and leads to a sustained senescence-associated inflammatory response", Nature Aging, DOI: 10.1038/s43587-022-00170-7, (link)

  3. Nguyen, C.L. et al., (2022), "Cannabidiol inhibits SARS-CoV-2 replication through induction of the host ER stress and innate immune responses", Science Advances, 8:ebai6110, DOI: 10.1126/sciadv.abi6110 (link)

  4. Essaidi-Laziosi, M., et al., (2021), "Sequential infections with rhinovirus and influenza modulate the replicative capacity of SARS-CoV-2 in the upper respiratory tract", Emerging Microbes & Infections, DOI: 10.1080/22221751.2021.2021806 (link)

  5. Lundberg, Rickard, et al. (2019). Zika Virus Non-Structural Protein NS5 Inhibits the RIG-I Pathway and Interferon Lambda 1 Promoter Activation by Targeting IKK Epsilon. Viruses, 20 pgs. PMID: 31690057. (link)

  6. Szabo, Peter, et al. (2019). Single-cell transcriptomics of human T cells reveals tissue and activation signatures in health and disease. Nature Communications, 16 pgs. PMID: 31624246. (link)

  7. Kuse, Nozomi, et al. (2019). Priming of HIV-1-specific CD8+ T cells with strong functional properties from naïve T cells. EBioMedicine, 11 pgs. PMID: 30956171. (link)

Documentation

Certificate of Analysis (CoA) and Safety Data Sheet (SDS)
39000-1 CoA

39000-1 Certificate of Analysis

39000 SDS

39000 Safety Data Sheet