Human Type 1 IFN Neutralizing Antibody Mixture

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Product Features: 
  • Mixture of monoclonal and polyclonal antibodies directed against human Type 1 Interferons (IFNs) and Type 1 Receptor Subunit 2 (IFNAR2)
  • Effectively neutralizes biological activity of human IFN-alpha, IFN-beta, IFN-omega, IFN-kappa, and IFN-epsilon
  • Improves neutralization of multiple Type I IFNs often found in complex samples by employing a broadly neutralizing custom antibody cocktail
  • Unconjugated

Ordering

Catalog No. Pack Size Price Quantity
39000-1

0.2 ml

 $645.00

Specifications

Formulation Supplied frozen in phosphate-buffered saline (PBS)
Purification A combination of Protein G affinity chromatography and other conventional chromatographical methods.
Endotoxin level < 1 EU/μg
Bioactivity Encephalomyocarditis Virus (EMCV) was used to challenge A549 cells which were incubated with a constant concentration of the antibody mixture and the titrated interferon.
Specificity Blocks biological activity of human Type I interferons (alpha, beta, omega, kappa, epsilon)
No cross reactivity observed with the following human interferons: gamma, lambda 1, lambda 2, lambda 3; or mouse interferons: alpha, beta, gamma
Storage For retention of full activity store at -70°C or below and avoid repeated freeze/thaw cycles
Synonyms Type I interferon, Type I IFN, Neutralizing, Neutralization, Type I Interferon Receptor, Antibody Cocktail

Tech Info / Data

Tested Applications:

  • Neutralization

Citations

6 Citations:

  1. Tsuji, S. et al., (2022), "SARS-CoV-2 infection triggers paracrine senescence and leads to a sustained senescence-associated inflammatory response", Nature Aging, DOI: 10.1038/s43587-022-00170-7, (link)
  2. Nguyen, C.L. et al., (2022), "Cannabidiol inhibits SARS-CoV-2 replication through induction of the host ER stress and innate immune responses", Science Advances, 8:ebai6110, DOI: 10.1126/sciadv.abi6110 (link)
  3. Essaidi-Laziosi, M., et al., (2021), "Sequential infections with rhinovirus and influenza modulate the replicative capacity of SARS-CoV-2 in the upper respiratory tract", Emerging Microbes & Infections, DOI: 10.1080/22221751.2021.2021806 (link)
  4. Lundberg, Rickard, et al. (2019). Zika Virus Non-Structural Protein NS5 Inhibits the RIG-I Pathway and Interferon Lambda 1 Promoter Activation by Targeting IKK Epsilon. Viruses, 20 pgs. PMID: 31690057. (link)

  5. Szabo, Peter, et al. (2019). Single-cell transcriptomics of human T cells reveals tissue and activation signatures in health and disease. Nature Communications, 16 pgs. PMID: 31624246. (link)

  6. Kuse, Nozomi, et al. (2019). Priming of HIV-1-specific CD8+ T cells with strong functional properties from naïve T cells. EBioMedicine, 11 pgs. PMID: 30956171. (link)

Documentation

Representative Neutralization Curves

Human Type I IFN Neutralization in A549 Cells

Representative neutralization curves of Human Type I IFN Neutralizing Antibody Mixture (Catalog No. 39000) (diluted 1:50) to human interferon alpha, beta, and omega. In this assay, A549 cells (human lung carcinoma) were incubated with the antibody mixture and titrated interferon, followed by challenging with encephalomyocarditis virus (EMCV).

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