Human Type 1 IFN Neutralizing Antibody Mixture
Specifications
| Formulation | Supplied frozen in phosphate-buffered saline (PBS) |
| Purification | A combination of Protein G affinity chromatography and other conventional chromatographical methods. Endotoxin level < 1 EU/μg |
| Bioactivity | Encephalomyocarditis Virus (EMCV) was used to challenge A549 cells which were incubated with a constant concentration of the antibody mixture and the titrated interferon. |
| Specificity | Blocks biological activity of human Type I interferons (alpha, beta, omega, kappa, epsilon) No cross reactivity observed with the following human interferons: gamma, lambda 1, lambda 2, lambda 3; or mouse interferons: alpha, beta, gamma |
| Storage | For retention of full activity store at -70°C or below and avoid repeated freeze/thaw cycles |
| Synonyms | Type I interferon, Type I IFN, Neutralizing, Neutralization, Type I Interferon Receptor, Antibody Cocktail |
Tech Info / Data
Tested Applications:
- Neutralization
Documentation
Representative Neutralization Curves
Representative neutralization curves of Human Type I IFN Neutralizing Antibody Mixture (Catalog No. 39000) (diluted 1:50) to human interferon alpha, beta, and omega. In this assay, A549 cells (human lung carcinoma) were incubated with the antibody mixture and titrated interferon, followed by challenging with encephalomyocarditis virus (EMCV).
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