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Full Product Name: Mouse Interleukin-28B (IL-28B)/Interferon Lambda 3, carrier-free
Catalog No. | Pack Size | Price | Quantity |
---|---|---|---|
12821-1 |
25 μg |
$505.00 |
Formulation | Supplied lyophilized without a carrier protein |
Molecular Weight | 19.7 kDa |
Source | DNA sequence encoding the mature mouse IL-28B/IFN-λ3 expressed in E.coli |
Purity | Greater than 95% Endotoxin level < 1 EU/μg |
Bioactivity | Human HepG2 cells infected with encephalomyocarditis virus. The ED50 is 7.5-37.5 ng/ml |
Storage | For retention of full activity store at -70°C or below and avoid repeated freeze/thaw cycles |
Synonyms | Mu IL-28B; Mu IFN-λ3 |
Accession Number | NP_796370 |
Human IL-28A, IL-28B, and IL-29, also named interferon-λ2 (IFN-λ2), IFN-λ3, and IFN-λ1, respectively, are newly identified class II cytokine receptor ligands that are distantly related to members of the IL-10 family (11- 13% aa sequence identity) and type I IFN family (15 - 19% aa sequence identity). The genes encoding these three cytokines are localized to chromosome 19 and each is composed of multiple exons. The exon organization of these genes is also found in the IL-10 family genes but is distinct from the type I IFNs, which are encoded within a single exon.
The expression of IL-28A, B, and IL-29 is induced by virus infection or double-stranded RNA. All three cytokines exert bioactivities that overlap those of type I IFNs, including antiviral activity and up-regulation of MHC class I antigen expression. The three proteins signal through the same heterodimeric receptor complex that is composed of the IL-10 receptor β (IL-10 Rβ) and a novel IL-28 receptor α (IL-28 Rα, also known as IFN-λR1). Ligand binding to the receptor complex induces Jak kinase activation and STAT1 and STAT2 tyrosine phosphorylation. The phosphorylated STAT1 and STAT2 complex with IFN-regulatory factor 9 (IRF-9) to form the IFN-stimulated regulatory factor 3 (ISGF-3) transcription factor complex that is translocated to the nucleus. ISGF-3 binds to the IFN-stimulated response element (ISRE) present in the regulatory regions of the target genes. Mouse IL-28B cDNA encodes a 193 amino acid (aa) residue precursor protein with a putative 15 aa signal peptide. It shares 61%, 62% and 52% aa sequence identity with human IL-28A, human IL-28B and human IL-29, respectively.
References:
Catalog No. | Description | Pack Size | Price | Quantity |
---|---|---|---|---|
12820-1 |
Mouse Interleukin-28B/Interferon Lambda 3 |
25 μg |
$505.00 |
|
62830-1 |
DIY Mouse IFN Lambda 2/3 (IL-28A/B) ELISA Compatibility: Tissue Culture Media Assay Range: 31.25 - 2000 pg/ml |
Materials for 15 x 96 wells |
$710.00 |
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PBL Assay Science offers scientists a comprehensive range of assay kits, interferons, cytokines, growth factors and antibodies. Our high quality products provide consistent, reliable performance and are suitable for use in a range of research applications.
Quick Search
PBL’s improved site search function is defaulted to an exact match.
Search Term Results |
|
IFN beta |
All interferon beta products and related technical information (e.g. technical notes) |
Human IFN beta |
All human interferon products related technical information (e.g. technical notes) |
IL-2 |
All products contain the term “IL-2”, including IL-23 |
IL 2 |
All products contain the term “IL 2”, including IL-23 |
Erythropoietin |
All EPO products and technical information |
Eryth |
All EPO products and technical information |
The results are displayed in best match products grouped in the following product category filters:
Each filter contains sub-categories for further narrowing of your search results
Other web content such as technical notes that contain the Search Term can be displayed by checking the box next to the corresponding filter on the left side of the Search Results Page.