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Human IFN-Lambda 3, Human Cell Expressed

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Human IFN-Lambda 3, Human Cell Expressed

Catalog Number: 11730

Recombinant Human IFN-Lambda 3 protein (Human IL-28B) is expressed in human cells and sold by active units. 


Pack Size
Product Info


Bioactivity Measured in cytopathic effect inhibition assay on human lung carcinoma cell line A549 with encephalomyocarditis virus (EMCV), EC50 ~1 U/ml


Only hIFNL protein qualified against the international reference standard for Human Interferon Lambda 3 (Hu-IFN-L3).


Formulation Supplied frozen in phosphate buffered saline (PBS) containing 0.1% bovine serum albumin (BSA)
Molecular Weight 19.6 kDa
Source Recombinant DNA expressed in human cells
Purity Greater than 95% as determined by ion exchange, hydrophobic interaction and/or size exclusion chromatography
Endotoxin level < 1 EU/μg
Storage For retention of full activity store at -70°C or below and avoid repeated freeze/thaw cycles
Synonyms Hu-IL-28B; Hu-IFN-λ3
Accession Number NP_742151.2

Tech Info & Data



IFN-Lambda 1 (IL-29), IFN-Lambda 2 (IL-28A) and IFN-Lambda 3 (IL-28B) are recently identified members of the IL-10 family, which have antiviral activity similar to type I interferons. They mediate this activity through a heterodimeric receptor complex that is composed of the IL-10 receptor β (IL-10 Rβ) and a novel IL-28 receptor α (IL-28 Rα, also known as IFN-λ R1). Engagement of this receptor leads to Jak-STAT signaling and gene expression. Many of the effects of interferon lambda on cells overlap that of Type I interferon. Unlike the type I interferon receptor which is on virtually all cells, the type III receptor is limited in its expression1. Interferon lambda 1 encodes a 181 AA mature protein which is 67% and 69% identical with interferon lambda 2 and interferon lambda 3, respectively.


1 Citation:


  1. Zhang, Q., et al.,(2022), "Autoantibodies against type I IFNs in patients with critical influenza pneumonia", J. Exp. Med. 219(11):e20220514, DOI: 10.1084/jem.20220514 (link)



  1. Donnelly, RP, et al. (2010). Interferon-lambda: A New Addition to an Old Family. Journal of Interferon & Cytokine Research, 9 pgs. PMID: 20712453. (link)


Certificate of Analysis (CoA) and Safety Data Sheet (SDS)
11730-1 CoA

11730-1 Certificate of Analysis (CoA)

11730 SDS

11730 Safety Data Sheet