Human IL-28A/IFN Lambda 2, HCE

Product Features: 
  • Only Human IFN Lambda proteins qualified against the international reference standard for Human Interferon Lambda 1 (Hu-IFN-λ1)
  • Packaged and sold by active units rather than mass
  • Authentic human cell origin

Full Product Name: Human Interleukin-28A/Interferon Lambda 2, Human Cell-Expressed (HCE)

Ordering

Catalog No. Pack Size Price Quantity
11720-1

≥ 1 x 105 units

$260.00

Specifications

Formulation Supplied frozen in phosphate buffered saline (PBS) containing 0.1% bovine serum albumin (BSA)
Molecular Weight 19.8 kDa
Source Recombinant DNA expressed in human cells
Purity Greater than 95% as determined by ion exchange, hydrophobic interaction and/or size exclusion chromatography
Endotoxin level < 1 EU/μg
Bioactivity Measured in cytopathic effect inhibition assay on human lung carcinoma cell line A549 with encephalomyocarditis virus (EMCV), EC50 ~1 U/ml
Storage For retention of full activity store at -70°C or below and avoid repeated freeze/thaw cycles
Synonyms Hu-IL-28A; Hu-IFN-λ2
Accession Number NP_742150.1

Tech Info / Data

Titration of Human Interleukin-28A/Interferon Lambda 2 (HCE)
Background: 

Interferon lambda 1 (IL-29), interferon lambda 2 (IL-28A) and interferon lambda 3 (IL-28B) are recently identified members of the IL-10 family, which have antiviral activity similar to type I interferons. They mediate this activity through a heterodimeric receptor complex that is composed of the IL-10 receptor β (IL-10 Rβ) and a novel IL-28 receptor α (IL-28 Rα, also known as IFN-λ R1). Engagement of this receptor leads to Jak-STAT signaling and gene expression. Many of the effects of interferon lambda on cells overlap that of Type I interferon. Unlike the type I interferon receptor which is on virtually all cells, the type III receptor is limited in its expression1. Interferon lambda 1 encodes a 181 AA mature protein which is 67% and 69% identical with interferon lambda 2 and interferon lambda 3, respectively.

Citations

Human Interleukin-28A/IFN Lambda 2 Titration

11720-1 Human Interleukin-28A/Interferon Lambda 2 (HCE)

Related Products

Catalog No. Description Pack Size Price Quantity
11725-1 Human IL-29/IFN Lambda 1, HCE  new 

≥ 1 x 105 units

$260.00
11730-1 Human IL-28B/IFN Lambda 3, HCE  new 

≥ 1 x 105 units

$260.00

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