C12R Mouse IFN-Alpha Decoy Receptor, Neutralizing
Catalog Number: 12185
Viral C12R IFN Antagonist selectively neutralizes all mouse IFN-Alpha subtypes. It is also suitable for Western Blot (WB) applications.
This product also neutralizes human IFN-Alpha, -Beta, and -Omega; rat IFN-Alpha 1; and mouse limitin.
Does not neutralize the following when tested at ≥100X the typical neutralizing dose
|Activity (EC50)||0.3 - 11.5 ng/ml (varies by subtype)|
|Formulation||Supplied frozen in phosphate-buffered saline (PBS) containing 0.1% Bovine Serum Albumin (BSA)|
|Molecular Weight||32 kDa|
|Purity||> 95% by SDS-PAGE stained by Coomassie Blue
Endotoxin level < 1 EU/μg
|Bioactivity||Measured by neutralization of interferon in a cytopathic effect inhibition assay.|
|Storage||For retention of full activity store at -70°C or below and avoid repeated freeze/thaw cycles|
Tech Info & Data
C12R is an interferon binding/blocking protein produced by many strains of Mousepox (Ectromelia) virus, (Smith and Alcami, J.Vir. 2002, 76:1124). This protein blocks the activity of mouse IFN-Alpha but not Beta. It is an essential protein for viral infection (Xu et al. JEM 2008 205:981).