C12R Mouse IFN Alpha Decoy Receptor, neutralizing

Product Features: 
  • Viral C12R IFN Antagonist selectively neutralizes all mouse IFN alpha subtypes
  • No cross-reactivity with mouse IFN beta
  • Also neutralizes all human IFN alpha subtypes, human IFN beta, human IFN omega, rat IFN alpha 1, and mouse limitin
  • Suitable for Western Blot

Ordering

Catalog No. Pack Size Price Quantity
12185-2

100 μg

$925.00
12185-1

10 μg

$275.00

Specifications

Formulation Supplied frozen in phosphate-buffered saline (PBS) containing 0.1% Bovine Serum Albumin (BSA)
Activity (EC50) 0.3 - 11.5 ng/ml (varies by subtype)
Molecular Weight 32 kDa
Purity > 95% by SDS-PAGE stained by Coomassie Blue
Endotoxin level < 1 EU/μg
Bioactivity Measured by neutralization of interferon in cytopathic effect inhibition assay.
Specificity Neutralizes all mouse IFN alpha subtypes, all human IFN alpha subtypes, human IFN beta, human IFN omega, rat IFN alpha 1, and mouse limitin.

Does not neutralize mouse IFN beta, human IFN gamma, human IFN lambda 1, human IFN lambda 2, human IFN lambda 3, or rat IFN alpha 14 when tested at ≥ 100X the typical neutralizing dose.

Storage For retention of full activity store at -70°C or below and avoid repeated freeze/thaw cycles

Tech Info / Data

Tested Applications:

  • Neutralization
  • Western Blot

C12R is an interferon binding/blocking protein produced by many strains of Mousepox (Ectromelia) virus, (Smith and Alcami, J.Vir. 2002, 76:1124).  This protein blocks activity of mouse IFN Alpha but not Beta. It is an essential protein for viral infection (Xu et al. JEM 2008 205:981). 

C12R Mouse IFN Alpha Decoy Receptor Neutralizing Activities (NU/mg)

C12R decoy receptor neutralizes all mouse IFN alpha subtypes

 

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