C12R Mouse IFN Alpha Decoy Receptor, neutralizing
Specifications
| Formulation | Supplied frozen in phosphate-buffered saline (PBS) containing 0.1% Bovine Serum Albumin (BSA) |
| Activity (EC50) | 0.3 - 11.5 ng/ml (varies by subtype) |
| Molecular Weight | 32 kDa |
| Purity | > 95% by SDS-PAGE stained by Coomassie Blue Endotoxin level < 1 EU/μg |
| Bioactivity | Measured by neutralization of interferon in cytopathic effect inhibition assay. |
| Specificity | Neutralizes all mouse IFN alpha subtypes, all human IFN alpha subtypes, human IFN beta, human IFN omega, rat IFN alpha 1, and mouse limitin.
Does not neutralize mouse IFN beta, human IFN gamma, human IFN lambda 1, human IFN lambda 2, human IFN lambda 3, or rat IFN alpha 14 when tested at ≥ 100X the typical neutralizing dose. |
| Storage | For retention of full activity store at -70°C or below and avoid repeated freeze/thaw cycles |
Tech Info / Data
Tested Applications:
- Neutralization
- Western Blot
C12R is an interferon binding/blocking protein produced by many strains of Mousepox (Ectromelia) virus, (Smith and Alcami, J.Vir. 2002, 76:1124). This protein blocks activity of mouse IFN Alpha but not Beta. It is an essential protein for viral infection (Xu et al. JEM 2008 205:981).
C12R Mouse IFN Alpha Decoy Receptor Neutralizing Activities (NU/mg)
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