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C12R Mouse IFN-Alpha Decoy Receptor, Neutralizing

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C12R Mouse IFN-Alpha Decoy Receptor, Neutralizing

Catalog Number: 12185

Viral C12R IFN Antagonist selectively neutralizes all mouse IFN-Alpha subtypes. It is also suitable for Western Blot (WB) applications.

 

This product also neutralizes human IFN-Alpha, -Beta, and -Omega; rat IFN-Alpha 1; and mouse limitin.

$310.00

Pack Size
Product Info

Tested Applications
  • Neutralization
  • Western Blot (WB)
Specificity

Neutralizes:

  • All mouse and human IFN-Alpha subtypes
  • Human IFN-Beta, IFN-Omega
  • Rat IFN-Alpha 1
  • Mouse limitin

 

Does not neutralize the following when tested at ≥100X the typical neutralizing dose

  • Mouse IFN-Beta
  • Human IFN-Gamma, IFN-Lambda 1, IFN-Lambda 2, IFN-Lambda 3
  • Rat IFN-Alpha 14
Activity (EC50) 0.3 - 11.5 ng/ml (varies by subtype)

Specifications

Formulation Supplied frozen in phosphate-buffered saline (PBS) containing 0.1% Bovine Serum Albumin (BSA)
Molecular Weight 32 kDa
Purity > 95% by SDS-PAGE stained by Coomassie Blue
Endotoxin level < 1 EU/μg
Bioactivity Measured by neutralization of interferon in a cytopathic effect inhibition assay.
Storage For retention of full activity store at -70°C or below and avoid repeated freeze/thaw cycles

Tech Info & Data

Background

 

C12R is an interferon binding/blocking protein produced by many strains of Mousepox (Ectromelia) virus, (Smith and Alcami, J.Vir. 2002, 76:1124).  This protein blocks the activity of mouse IFN-Alpha but not Beta. It is an essential protein for viral infection (Xu et al. JEM 2008 205:981). 

Documentation

Certificate of Analysis (CoA) and Safety Data Sheet (SDS)
12185-1 CoA

12185-1 Certificate of Analysis (CoA)

12185-2 CoA

12185-2 Certificate of Analysis (CoA)

12185 SDS

12185 Safety Data Sheet