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Anti-Human IFN-Alpha/Beta Receptor Chain 2, Clone MMHAR-2 (MAb)

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Anti-Human IFN-Alpha/Beta Receptor Chain 2, Clone MMHAR-2 (MAb)

Catalog Number: 21385

This well-cited and popular antibody blocks the biological action of Human Type I interferons. It is suitable for use in Type I IFN neutralization, flow cytometry, immunohistochemistry, and immunoprecipitation.


Pack Size
Product Info

SpecificityNeutralizes human IFN-Alpha receptor; interacts with extracellular domain; binds to human IFN-Alpha receptor with high affinity; blocks biological action of Type I IFNs
Tested Application
  • Neutralization
Suggested Applications*
  • Immunoprecipitation (1-5 μg/ml)
  • Immunohistochemistry (1 μg/ml)
  • Flow Cytometry (1-10 μg/ml)


*Please note that these applications are presented for suggested use only and have not been fully evaluated by PBL.


The Type I interferon receptor is a heterodimer consisting of IFNAR1 and IFNAR2. The IFNAR2 subunit provides most of the binding affinity for IFN and IFNAR1 is required for optimum signaling.


Full Product Name: Anti-Human Interferon Alpha/Beta Receptor Chain 2, Clone MMHAR-2 (MAb)


FormulationSupplied frozen in phosphate-buffered saline (PBS) containing 0.1% Bovine Serum Albumin (BSA)
AntigenHuman interferon alpha/beta receptor chain 2 (Human IFNAR2)
Host SpeciesMouse
Purity> 95% by SDS-PAGE stained by Coomassie Blue
Endotoxin level < 1 EU/μg
BioactivityMeasured by neutralization of interferon in cytopathic effect inhibition assay.
StorageFor retention of full activity store at -70°C or below and avoid repeated freeze/thaw cycles
Antigen SynonymsNone


58 Citations


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  28. Bowers, et al. (2014). Immune Suppression by Neutrophils in HIV-1 Infection: Role of PD-L1/PD-1 Pathway. PLOS One, 9 pgs. PMID: 24626392. (link)
  29. Tsugawa, et al. (2014). Critical Role of Interferon-alpha Constitutively Produced in Human Hepatocytes in Response to RNA Virus Infection. PLOS One, 9 pgs. PMID: 24587086. (link)
  30. Schijf, et al. (2013). Respiratory Syncytical Virus Induced Type I IFN Production by pDC is Regulated by RSV-Infected Airway Epithelial Cells, RSV-Exposed Monocytes and Virus Specific Antibodies. PLOS One, 18 pgs. PMID: 24303065. (link)
  31. Jing, et al. (2014). Intracellular Poly(I:C) Initiated Gastric Adenocarcinoma Cell Apoptosis and Subsequently Ammeliorated NK Cell Functions. Journal of Interferon & Cytokine Research. PMID: 24032591. (link)
  32. Rodrigues, et al. (2013). Candida albicans Delays HIV-1 Replication in Macrophages. PLOS One, 11 pgs. PMID: 24009706. (link)
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  39. Moll, et al. (2008). Neutralizing type I IFN antibodies trigger an IFN-like response in endothelial cells. Journal of Immunology, 8 pgs. PMID: 18390705. (link)
  40. Davis, Ann, et al. (2008). A T-bet-independent role for IFN-α/β in regulating IL-2 secretion in human CD4+ central memory T cells. Journal of Immunology, 11 pgs. PMID: 19050236. (link)
  41. Marijanovic, Zrinka, et al. (2007). Comparable potency of IFNα2 and IFNβ on immediate JAK/STAT activation but differential down-regulation of IFNAR2. Biochemical Journal, 11 pgs. PMID: 17627610. (link)
  42. Hasan, Uzma, et al. (2007). Cell proliferation and survival induced by Toll-like receptors is antagonized by type I IFNs. PNAS, 6 pgs. PMID: 17463087. (link)
  43. Conti, Laura, et al. (2007). In the absence of IGF-1 signaling, IFN-gamma suppresses human malignant T-cell growth. Blood Journal, 10 pgs. PMID: 17148586. (link)
  44. van Boxel-Dezaire, Annette, et al. (2006). Complex modulation of cell type-specific signaling in response to type I interferons. Immunity, 12 pgs. PMID: 16979568. (link)
  45. Best, et al. (2005). Inhibition of interferon-stimulated JAK-STAT signaling by a tick-borne flavivirus and identification of NS5 as an interferon antagonist. JVI, 12 pgs. PMID: 16188985. (link)
  46. Bendriss-Vermare, Nathalie, et al. (2005). Virus overrides the propensity of human CD40L-activated plasmacytoid dendritic cells to produce Th2 mediators through synergistic induction of IFN-{gamma} and Th1 chemokine production. JLB, 13 pgs. PMID: 16081597. (link)
  47. Nestle, Frank, et al. (2005). Plasmacytoid predendritic cells initiate psoriasis through interferon-α production. JEM, 9 pgs. PMID: 15998792. (link)
  48. Gautier, Gregory, et al. (2005). A type I interferon autocrine–paracrine loop is involved in Toll-like receptor-induced interleukin-12p70 secretion by dendritic cells. JEM, 12 pgs. PMID: 15851485. (link)
  49. Bekeredjian-Ding, Isabelle, et al. (2005). Plasmacytoid dendritic cells control TLR7 sensitivity of naive B cells via type I IFN. Journal of Immunology, 10 pgs. PMID: 15778362. (link)
  50. Gustincich, Stefano, et al. (2004). Gene discovery in genetically labeled single dopaminergic neurons of the retina. PNAS, 6 pgs. PMID: 15047890. (link)
  51. Kato, Atsushi, et al. (2003). Interferon-α/β receptor-mediated selective induction of a gene cluster by CpG oligodeoxynucleotide 2006. BMC Immunology, 10 pgs. PMID: 12887736. (link)
  52. Dondi, Elisabetta, et al. (2003). Down-modulation of responses to type I IFN upon T cell activation. Journal of Immunology, 9 pgs. PMID: 12517937. (link)
  53. Zou, Weiping, et al. (2001). Reciprocal regulation of plasmacytoid dendritic cells and monocytes during viral infection. European Journal of Immunology, 7 pgs. PMID: 11745405. (link)
  54. Dondi, Elisabetta, et al. (2001). Down-modulation of type 1 interferon responses by receptor cross-competition for a shared Jak kinase. JBC, 10 pgs. PMID: 11602573. (link)
  55. Schlender, Joerg, et al. (2000). Bovine Respiratory Syncytial Virus Nonstructural Proteins NS1 and NS2 Cooperatively Antagonize Alpha/Beta Interferon-Induced Antiviral Response. JVI, 9 pgs. PMID: 10954520. (link)
  56. Colamonici, Oscar, et al. (1993). Identification of a Novel Subunit of the Type I Interferon Receptor Localized to Human Chromosome 21. JBC, 5 pgs. PMID: 8496154. (link)
  57. Muendlein H, et al. (2020) Constitutive Interferon Attenuates RIPK1/3-Mediated Cytokine Translation. Cell Reports , 14 pgs. (link)
  58. Boussier J, et al. (2020) Chikungunya Virus Superinfection Exclusion is Mediated by a Block in Viral Replication and Does Not Rely on Non-Structural Protein 2. PLOS ONE., (link)


Background Literature:


  1. Colamonici, Oscar, et al. (1993). Identification of a Novel Subunit of the Type I Interferon Receptor Localized to Human Chromosome 21. JBC, 5 pgs. PMID: 8496154. (link)


Certificate of Analysis (CoA) and Safety Data Sheet (SDS)
21385-1 CoA

21385-1 Certificate of Analysis

21385 SDS

21385 Safety Data Sheet