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Single Molecule Counting (SMCxPRO & Erenna) Assay Services: Sensitive Cytokine Testing

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MilliporeSigma Single Molecule Counting (SMCxPRO® & Erenna®)

  • Cytokine analysis utilizing Single Molecule Counting technology enables sub-pg/ml sensitivity for accurate measurement of low abundance biomarkers in normal or disease sera/plasma

  • Minimal sample dilution requirement with 4-Log+ dynamic range

  • High precision cytokine immunoassays provide reproducible data

  • Extensive analyte menu of over 40 different cytokine assays covering several disease areas including IFN-γ, IL-1a, IL-1b, IL-4, IL-6, IL-8, IL-10, IL-13, IL-15, IL-17A, IL-17F, IL-17 heterodimer, IL-23, GLP-1, and TNF-α

PBL Assay Science's ultra-sensitive cytokine detection services are powered by MilliporeSigma's Single Molecule Counting technology in conjunction with robust microparticle (MP) based sandwich immunoassays that enables accurate, high-precision baseline quantification of low-abundance analytes at or below sub-picogram concentrations.

The ability to accurately measure low-abundance analytes present in complex matrices is essential for the profiling and characterization of cytokines and other biomarker analytes. Employing proprietary single molecule counting technology with robust microparticle-based SMCxPRO® & Erenna® immunoassays, PBL’s cytokine detection services can provide scientists with sub-pg/ml level measurements of low-abundance analytes in healthy or disease sera and plasma.

The background reduction methodology of this detection service extends the linear dynamic range to over 4 logs allowing scientists to measure biomarkers in many disease states at unprecedented levels. In addition to minimal sample dilution, robust and reproducible data make this detection service a great tool that can help scientists come to an increased understanding of analyte activities in biological responses.

 

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Key Features offered by Single Molecule Counting Technology on SMCxPRO and Erenna Platforms:

  • Enables sub-pg/ml sensitivity for accurate measurement of low abundance biomarkers in serum, plasma or other complex matrices

  • Requires minimal sample dilution with a 4-Log+ dynamic range

  • Provides high precision and reproducible data

  • Extensive analyte menu of over 30 different cytokine assays covering several disease areas

 

Powered by SMCxPRO® & Erenna® Immunoassay Systems, MilliporeSigma Inc., Burlington, MA, USA.

PBL Singulex Erenna shows the ability to measure low levels of IL-1 Beta in Plasma samples (Heparin, Citrate, and EDTA)
Figure 1. Median levels of IL-1b (Interleukin 1 Beta) in Plasma Samples (Heparin, Citrate and EDTA)