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Human IFN-Alpha

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Human IFN-Alpha proteins are found as multiple subtypes produced by a viral infection, immune stimulators, and chemical inducers. These type I interferon alpha proteins differentially exhibit antiviral, antiproliferative, and immunomodulatory activities. When interferon alpha interacts with its cognate receptor, a signal is rapidly transmitted within the cell, often producing an antiviral state. The primary signal transduction cascade promoted by type I interferons is the JAK1-STAT pathway. Activation of this cascade leads to increased expression of a large number of genes, including (2'-5') oligoadenylate synthetases, Mx proteins, and protein kinase R (PKR) that protect the cell from viral infection. Interferon Alpha 2a and Alpha 2b are the most widely used therapeutic interferon alpha proteins, and have been modified with polyethylene glycol sidechains to yield therapeutic interferons with extended half-lives.

 

First approved for the treatment of Hairy Cell Leukemia, interferon alpha has been utilized extensively as a therapeutic intervention to treat patients with Hepatitis B, Hepatitis C, Melanoma, and T-cell Lymphoma. Though the detailed biological mechanisms responsible for the actual and potential therapeutic activities and varied biological sequelae of each of the type I interferon alpha subtypes are not well defined in most cases, this family of interferon proteins comprises an important area of life science and therapeutic investigation.

Catalog No. Description Pack size Price Quantity
11200-1 Human IFN-Alpha Hybrid Protein (Universal Type I IFN) 1 x 10⁵ units $480.00
11200-2 Human IFN-Alpha Hybrid Protein (Universal Type I IFN) 1 x 10⁶ units $755.00
11002-1 Human IFN-Alpha Sampler Set 1 x 10⁵ units $2,650.00
11100-1 Human IFN-Alpha A (Alpha 2a) 5 x 10⁶ units $335.00
11101-1 Human IFN-Alpha A (Alpha 2a), Carrier-Free 5 μg $260.00
11101-2 Human IFN-Alpha A (Alpha 2a), Carrier-Free 20 μg $430.00
11105-1 Human IFN-Alpha 2 (Alpha 2b) 1 x 10⁵ units $335.00
11115-1 Human IFN-Alpha B2 (Alpha 8) 1 x 10⁵ units $335.00
11120-1 Human IFN-Alpha C (Alpha 10) 1 x 10⁵ units $335.00
11125-1 Human IFN-Alpha D (Alpha 1) 1 x 10⁵ units $335.00
11130-1 Human IFN-Alpha F (Alpha 21) 1 x 10⁵ units $335.00
11135-1 Human IFN-Alpha G (Alpha 5) 1 x 10⁵ units $335.00
11145-1 Human IFN-Alpha H2 (Alpha 14) 1 x 10⁵ units $335.00
11150-1 Human IFN-Alpha I (Alpha 17) 1 x 10⁵ units $335.00
11160-1 Human IFN-Alpha J1 (Alpha 7) 1 x 10⁵ units $335.00
11165-1 Human IFN-Alpha K (Alpha 6) 1 x 10⁵ units $335.00
11175-1 Human IFN-Alpha 1 (Alpha D) 1 x 10⁵ units $335.00
11177-1 Human IFN-Alpha 4a (Alpha M1) 1 x 10⁵ units $335.00
11180-1 Human IFN-Alpha 4b (Alpha 4) 1 x 10⁵ units $335.00
11190-1 Human IFN-Alpha WA (Alpha 16) 1 x 10⁵ units $335.00