Human IFN-Alpha D (Alpha 1)
Catalog Number: 11125
Human IFN-Alpha 1 recombinant protein expressed in E.coli.
Recombinant Human Interferon Alpha D (Hu-IFN-alpha D; Hu-[Val114] IFN-Alpha 1) obtained from human leukocyte mRNA expressed in E.coli.
IFN-Alpha 1 is one of the many interferon alpha subtypes belonging to the Type I leukocyte IFN family. The Type I IFN family has antiviral, anti-proliferative, and natural killer cell activities.
- Expression is induced by viral infection
- Encoding gene IFNA1 at position Val114
|Formulation||Supplied frozen in phosphate-buffered saline (PBS) containing 0.1% Bovine Serum Albumin (BSA)|
|Molecular Weight||19.4 kDa|
|Source||cDNA obtained from human leukocyte mRNA expressed in E.coli|
|Purity||> 95% by SDS-PAGE stained by Coomassie Blue|
|Bioactivity||Measured using a cytopathic inhibition assay on Bovine Kidney Cells (MDBK) with Vesicular Stomatis Virus (VSV); human lung carcinoma cell line A549 with encephalomyocarditis virus (EMCV)|
|Storage||For retention of full activity store at -70 ºC or below and avoid repeated freeze-thaw cycles|
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- Wu, TG, et al. (2007). IFN-alpha-induced murine B16 melanoma cancer vaccine cells: induction and accumulation of cell-associated IL-15. Journal of Interferon & Cytokine Research. PMID: 17266439. (link)
- Kang, Dong-Chul, et al. (2004). Expression Analysis and Genomic Characterization of Human Melanoma Differentiation Associated Gene-5, mda-5: a Novel Type I Interferon-Responsive Apoptosis-Inducing Gene. Oncogene, 12 pgs. PMID: 14676839. (link)