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Human IFN-Alpha 2 (Alpha 2b)

Hero Region

Human IFN-Alpha 2 (Alpha 2b)

Catalog Number: 11105

Human Interferon Alpha 2b recombinant protein expressed in E.coli.


Pack Size
Product Info

IFN-Alpha 2 (Alpha 2b) is one of the many interferon alpha subtypes belonging to the Type I leukocyte IFN family. The Type I IFN family has antiviral, anti-proliferative and natural killer cell activities.


Formulation Supplied frozen in phosphate-buffered saline (PBS) containing 0.1% Bovine Serum Albumin (BSA)
Molecular Weight 19.3 kDa
Source Human leukocyte interferon alpha 2b cDNA expressed in E.coli
Purity > 95% by SDS-PAGE stained by Coomassie Blue
Bioactivity Measured using a cytopathic inhibition assay on Bovine Kidney Cells (MDBK) with Vesicular Stomatis Virus (VSV); human lung carcinoma cell line A549 with encephalomyocarditis virus (EMCV)
Storage For retention of full activity store at -70°C or below and avoid repeated freeze/thaw cycles
Synonyms Interferon alpha 2, IFNa2, IFN alpha2b, IFN alpha, IFN-a, interferon alpha, IFN alpha 2, IFN-a2, alpha interferon, interferon alfa, IFN alfa, interferon a, interferon alpha 2b, IFN alpha 2b, Type I interferon alpha, Type I IFN alpha
Accession Number V00548

Tech Info & Data

Application Notes


  • Polyclonal Antibodies Neutralization of Human Interferon Alpha (link
  • A Comparison of the Binding of Interferon Alpha Subtypes to Isolated IFNAR1 and IFNAR2 with Activity in Antiviral and Antiproliferative Assays (link)


12 Citations


  1. Unali, G., et al.,  (2023), "Interferon-inducible phospholipids govern IFITM3-dependent endosomal antiviral immunity", EMBO J., e112234, PMID: 36970857, DOI: 10.15252/embj.2022112234 (link)

  2. Zhu,, G. et al., (2023),"Type I Interferonopathy due to a Homozygous Loss-of-Inhibitory Function Mutation in STAT2", J. Clin. Immunol., PMID: 36753016, DOI: 10.1007/s10875-023-01445-3 (link)

  3. Singh, M., et al., (2021), "A virus-derived microRNA targets immune response genes during SARS-CoV-2 infection", EMBO Reports, e54341, DOI:10.15252/embr.202154341 (link)

  4. Odhams, et al. (2019). Interferon inducible X-linked gene CXorf21 may contribute to sexual dimorphism in Systemic Lupus Erythematosus. Nature Communications, 15 pgs. PMID: 31092820. (link)

  5. He, et al. (2019). A Human Papillomavirus-Independent Cervical Cancer Animal Model Reveals Unconventional Mechanisms of Cervical Carcinogenesis. Cell Reports. PMID: 30840887. (link)

  6. Petrillo, Carolina, et al. (2018). Cyclosporine H Overcomes Innate Immune Restrictions to Improve Lentiviral Transduction and Gene Editing in Human Hematopoietic Stem Cells. Cell Reports, 23 pgs. PMID: 30416070. (link)

  7. Zhang, Sen, et al. (2018). Up-Regulation of MicroRNA-203 in Influenza A Virus Infection Inhibits Viral Replication by Targeting DR1. Scientific Reports, 15 pgs. PMID: 29717211. (link)

  8. Kishimoto, Daiga, et al. (2018). Dysregulated Heme Oxygenase-1^(low) M2-Like Macrophages Augment Lupus Nephritis via Bach1 Induced by Type I Interferons. Arthritis Research & Therapy, 11 pgs. PMID: 29636091. (link)

  9. Mohamed, Abdel-Mohsen, et al. (2014). Role of microRNA modulation in the interferon-α/ribavirin suppression of HIV-1 in vivo. PLOS One, 9 pgs. PMID: 25275557. (link)

  10. Wilson, Timothy R, et al. (2012). Widespread potential for growth-factor-driven resistance to anticancer kinase inhibitors. Nature, 12 pgs. PMID: 22763448. (link)

  11. Cheng, et al. (2011). Establishment, Characterization, and Successful Adaptive Therapy Against Human Tumors of NKG Cell, a New Human NK Cell Line. Cell Transplantation. PMID: 21669033. (link)

  12. Lee, et al. (2007). Type I interferon as a novel risk factor for endothelial progenitor cell depletion and endothelial dysfunction in systemic lupus erythematosus. Arthritis and Rheumatism. PMID: 17968925. (link)


Certificate of Analysis (CoA) and Safety Data Sheet (SDS)
11105-1 CoA

11105-1 Certificate of Analysis (CoA)

11105 SDS

11105 Safety Data Sheet