Skip to main content

Human IFN-Alpha 2b (Alpha 2) Protein

Hero Region

Human IFN-Alpha 2b (Alpha 2) Protein

Catalog Number: 11105

  • Human Interferon Alpha 2b recombinant protein expressed in E.coli.

  • Lot-Specific Activity (Unit/ml) allows accurate amount of active protein is being used for each experiment

  • 95% or greater purity with less than 1 EU/ug endotoxin

  • Custom carrier-free bulk available upon request

$335.00

Pack Size
Product Info

IFN-Alpha 2 (Alpha 2b) is one of the many interferon alpha subtypes belonging to the Type I leukocyte IFN family. The Type I IFN family has antiviral, anti-proliferative and natural killer cell activities.

Specifications

FormulationSupplied frozen in phosphate-buffered saline (PBS) containing 0.1% Bovine Serum Albumin (BSA)
Molecular Weight19.3 kDa
SourceHuman leukocyte interferon alpha 2b cDNA expressed in E.coli
Purity> 95% by SDS-PAGE stained by Coomassie Blue
BioactivityMeasured using a cytopathic inhibition assay on Bovine Kidney Cells (MDBK) with Vesicular Stomatis Virus (VSV); human lung carcinoma cell line A549 with encephalomyocarditis virus (EMCV)
StorageFor retention of full activity store at -70°C or below and avoid repeated freeze/thaw cycles
SynonymsInterferon alpha 2, IFNa2, IFN alpha2b, IFN alpha, IFN-a, interferon alpha, IFN alpha 2, IFN-a2, alpha interferon, interferon alfa, IFN alfa, interferon a, interferon alpha 2b, IFN alpha 2b, Type I interferon alpha, Type I IFN alpha
Accession NumberV00548

Tech Info & Data

Application Notes

 

  • Polyclonal Antibodies Neutralization of Human Interferon Alpha (link
  • A Comparison of the Binding of Interferon Alpha Subtypes to Isolated IFNAR1 and IFNAR2 with Activity in Antiviral and Antiproliferative Assays (link)

Citations

15 Citations

 

  1. Zhang, Y. et al., (2024), "IFN-a affects Th17/Treg cell balance through c-Maf and associated with the progression of EBV-SLE", Mol Immunol.,  171:23-35, PMID: 38749236, DOI: 10.1016/j.molimm.2024.05.003 (link)
  2. Quellec, J. et al., (2023), "Rift Valley fever virus modulates apoptosis and immune response during infection of human astrocytes", Emerg Microbes Infect., PMID: 37306630, DOI: 10.1080/22221751.2023.2207672 (link)
  3. Barer, L. et al., (2023), "Lipocalin-2 regulates the expression of interferon-stimulated genes and the susceptibility of prostate cancer cells to oncolytic virus infection", Euro. J. Cell Biol., DOI: 10.1016/j. ejcb.2023.151328 (link)
  4. Unali, G., et al.,  (2023), "Interferon-inducible phospholipids govern IFITM3-dependent endosomal antiviral immunity", EMBO J., e112234, PMID: 36970857, DOI: 10.15252/embj.2022112234 (link)
  5. Zhu,, G. et al., (2023),"Type I Interferonopathy due to a Homozygous Loss-of-Inhibitory Function Mutation in STAT2", J. Clin. Immunol., PMID: 36753016, DOI: 10.1007/s10875-023-01445-3 (link)
  6. Singh, M., et al., (2021), "A virus-derived microRNA targets immune response genes during SARS-CoV-2 infection", EMBO Reports, e54341, DOI:10.15252/embr.202154341 (link)
  7. Odhams, et al. (2019). Interferon inducible X-linked gene CXorf21 may contribute to sexual dimorphism in Systemic Lupus Erythematosus. Nature Communications, 15 pgs. PMID: 31092820. (link)
  8. He, et al. (2019). A Human Papillomavirus-Independent Cervical Cancer Animal Model Reveals Unconventional Mechanisms of Cervical Carcinogenesis. Cell Reports. PMID: 30840887. (link)
  9. Petrillo, Carolina, et al. (2018). Cyclosporine H Overcomes Innate Immune Restrictions to Improve Lentiviral Transduction and Gene Editing in Human Hematopoietic Stem Cells. Cell Reports, 23 pgs. PMID: 30416070. (link)
  10. Zhang, Sen, et al. (2018). Up-Regulation of MicroRNA-203 in Influenza A Virus Infection Inhibits Viral Replication by Targeting DR1. Scientific Reports, 15 pgs. PMID: 29717211. (link)
  11. Kishimoto, Daiga, et al. (2018). Dysregulated Heme Oxygenase-1^(low) M2-Like Macrophages Augment Lupus Nephritis via Bach1 Induced by Type I Interferons. Arthritis Research & Therapy, 11 pgs. PMID: 29636091. (link)
  12. Mohamed, Abdel-Mohsen, et al. (2014). Role of microRNA modulation in the interferon-α/ribavirin suppression of HIV-1 in vivo. PLOS One, 9 pgs. PMID: 25275557. (link)
  13. Wilson, Timothy R, et al. (2012). Widespread potential for growth-factor-driven resistance to anticancer kinase inhibitors. Nature, 12 pgs. PMID: 22763448. (link)
  14. Cheng, et al. (2011). Establishment, Characterization, and Successful Adaptive Therapy Against Human Tumors of NKG Cell, a New Human NK Cell Line. Cell Transplantation. PMID: 21669033. (link)
  15. Lee, et al. (2007). Type I interferon as a novel risk factor for endothelial progenitor cell depletion and endothelial dysfunction in systemic lupus erythematosus. Arthritis and Rheumatism. PMID: 17968925. (link)

Documentation

Certificate of Analysis (CoA) and Safety Data Sheet (SDS)
11105-1 CoA

11105-1 Certificate of Analysis (CoA)

11105 SDS

11105 Safety Data Sheet