Skip to main content

Human IFN-Alpha 2b (Alpha 2) Protein

Hero Region

Human IFN-Alpha 2b (Alpha 2) Protein

Catalog Number: 11105

  • Human Interferon Alpha 2b recombinant protein expressed in E.coli.

  • Lot-Specific Activity (Unit/ml) allows accurate amount of active protein is being used for each experiment

  • 95% or greater purity with less than 1 EU/ug endotoxin

  • Custom carrier-free bulk available upon request


Pack Size
Product Info

IFN-Alpha 2 (Alpha 2b) is one of the many interferon alpha subtypes belonging to the Type I leukocyte IFN family. The Type I IFN family has antiviral, anti-proliferative and natural killer cell activities.


FormulationSupplied frozen in phosphate-buffered saline (PBS) containing 0.1% Bovine Serum Albumin (BSA)
Molecular Weight19.3 kDa
SourceHuman leukocyte interferon alpha 2b cDNA expressed in E.coli
Purity> 95% by SDS-PAGE stained by Coomassie Blue
BioactivityMeasured using a cytopathic inhibition assay on Bovine Kidney Cells (MDBK) with Vesicular Stomatis Virus (VSV); human lung carcinoma cell line A549 with encephalomyocarditis virus (EMCV)
StorageFor retention of full activity store at -70°C or below and avoid repeated freeze/thaw cycles
SynonymsInterferon alpha 2, IFNa2, IFN alpha2b, IFN alpha, IFN-a, interferon alpha, IFN alpha 2, IFN-a2, alpha interferon, interferon alfa, IFN alfa, interferon a, interferon alpha 2b, IFN alpha 2b, Type I interferon alpha, Type I IFN alpha
Accession NumberV00548

Tech Info & Data

Application Notes


  • Polyclonal Antibodies Neutralization of Human Interferon Alpha (link
  • A Comparison of the Binding of Interferon Alpha Subtypes to Isolated IFNAR1 and IFNAR2 with Activity in Antiviral and Antiproliferative Assays (link)


15 Citations


  1. Zhang, Y. et al., (2024), "IFN-a affects Th17/Treg cell balance through c-Maf and associated with the progression of EBV-SLE", Mol Immunol.,  171:23-35, PMID: 38749236, DOI: 10.1016/j.molimm.2024.05.003 (link)
  2. Quellec, J. et al., (2023), "Rift Valley fever virus modulates apoptosis and immune response during infection of human astrocytes", Emerg Microbes Infect., PMID: 37306630, DOI: 10.1080/22221751.2023.2207672 (link)
  3. Barer, L. et al., (2023), "Lipocalin-2 regulates the expression of interferon-stimulated genes and the susceptibility of prostate cancer cells to oncolytic virus infection", Euro. J. Cell Biol., DOI: 10.1016/j. ejcb.2023.151328 (link)
  4. Unali, G., et al.,  (2023), "Interferon-inducible phospholipids govern IFITM3-dependent endosomal antiviral immunity", EMBO J., e112234, PMID: 36970857, DOI: 10.15252/embj.2022112234 (link)
  5. Zhu,, G. et al., (2023),"Type I Interferonopathy due to a Homozygous Loss-of-Inhibitory Function Mutation in STAT2", J. Clin. Immunol., PMID: 36753016, DOI: 10.1007/s10875-023-01445-3 (link)
  6. Singh, M., et al., (2021), "A virus-derived microRNA targets immune response genes during SARS-CoV-2 infection", EMBO Reports, e54341, DOI:10.15252/embr.202154341 (link)
  7. Odhams, et al. (2019). Interferon inducible X-linked gene CXorf21 may contribute to sexual dimorphism in Systemic Lupus Erythematosus. Nature Communications, 15 pgs. PMID: 31092820. (link)
  8. He, et al. (2019). A Human Papillomavirus-Independent Cervical Cancer Animal Model Reveals Unconventional Mechanisms of Cervical Carcinogenesis. Cell Reports. PMID: 30840887. (link)
  9. Petrillo, Carolina, et al. (2018). Cyclosporine H Overcomes Innate Immune Restrictions to Improve Lentiviral Transduction and Gene Editing in Human Hematopoietic Stem Cells. Cell Reports, 23 pgs. PMID: 30416070. (link)
  10. Zhang, Sen, et al. (2018). Up-Regulation of MicroRNA-203 in Influenza A Virus Infection Inhibits Viral Replication by Targeting DR1. Scientific Reports, 15 pgs. PMID: 29717211. (link)
  11. Kishimoto, Daiga, et al. (2018). Dysregulated Heme Oxygenase-1^(low) M2-Like Macrophages Augment Lupus Nephritis via Bach1 Induced by Type I Interferons. Arthritis Research & Therapy, 11 pgs. PMID: 29636091. (link)
  12. Mohamed, Abdel-Mohsen, et al. (2014). Role of microRNA modulation in the interferon-α/ribavirin suppression of HIV-1 in vivo. PLOS One, 9 pgs. PMID: 25275557. (link)
  13. Wilson, Timothy R, et al. (2012). Widespread potential for growth-factor-driven resistance to anticancer kinase inhibitors. Nature, 12 pgs. PMID: 22763448. (link)
  14. Cheng, et al. (2011). Establishment, Characterization, and Successful Adaptive Therapy Against Human Tumors of NKG Cell, a New Human NK Cell Line. Cell Transplantation. PMID: 21669033. (link)
  15. Lee, et al. (2007). Type I interferon as a novel risk factor for endothelial progenitor cell depletion and endothelial dysfunction in systemic lupus erythematosus. Arthritis and Rheumatism. PMID: 17968925. (link)


Certificate of Analysis (CoA) and Safety Data Sheet (SDS)
11105-1 CoA

11105-1 Certificate of Analysis (CoA)

11105 SDS

11105 Safety Data Sheet