Human IFN-Alpha F (Alpha 21)
Catalog Number: 11130
Human Interferon Alpha 21 recombinant protein expressed in E.coli.
Recombinant Human IFN-Alpha F (alpha 21) obtained from human leukocyte mRNA expressed in E.coli.
IFN-Alpha 21 is one of the many interferon alpha subtypes belonging to the Type I leukocyte IFN family. The Type I IFN family has antiviral, anti-proliferative, and natural killer cell activities.
- Expression is induced by viral infection
- Encoding gene IFNA21
|Formulation||Supplied frozen in phosphate-buffered saline (PBS) containing 0.1% Bovine Serum Albumin (BSA)|
|Molecular Weight||19.3 kDa|
|Source||cDNA obtained from human leukocyte mRNA expressed in E.coli|
|Purity||> 95% by SDS-PAGE stained by Coomassie Blue|
|Bioactivity||Measured using a cytopathic inhibition assay on Bovine Kidney Cells (MDBK) with Vesicular Stomatis Virus (VSV); human lung carcinoma cell line A549 with encephalomyocarditis virus (EMCV)|
|Storage||For retention of full activity store at -70 ºC or below and avoid repeated freeze-thaw cycles|
Tech Info & Data
- A Comparison of the Binding of IFN-Alpha Subtypes to Isolated IFNAR1 and IFNAR2 with Activity in Antiviral and Antiproliferative Assays (link)
- Wilson, Timothy R, et al. (2012). Widespread potential for growth-factor-driven resistance to anticancer kinase inhibitors. Nature, 12 pgs. PMID: 22763448. (link)
- Kang, Dong-Chul, et al. (2004). Expression Analysis and Genomic Characterization of Human Melanoma Differentiation Associated Gene-5, mda-5: a Novel Type I Interferon-Responsive Apoptosis-Inducing Gene. Oncogene, 12 pgs. PMID: 14676839. (link)
- Hilkens, Catharien, et al. (2003). Differential responses to IFN-alpha subtypes in human T cells and dendritic cells. Journal of Immunology, 10 pgs. PMID: 14607926. (link)