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Human IFN-Alpha 21 (Alpha F) Protein

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Human IFN-Alpha 21 (Alpha F) Protein

Catalog Number: 11130

Human Interferon Alpha 21 recombinant protein expressed in E.coli


Pack Size
Product Info

Recombinant Human IFN-Alpha F (alpha 21) obtained from human leukocyte mRNA expressed in E.coli.


IFN-Alpha 21 is one of the many interferon alpha subtypes belonging to the Type I leukocyte IFN family.  The Type I IFN family has antiviral, anti-proliferative, and natural killer cell activities. 


  • Expression is induced by viral infection
  • Encoding gene IFNA21


Formulation Supplied frozen in phosphate-buffered saline (PBS) containing 0.1% Bovine Serum Albumin (BSA)
Molecular Weight 19.3 kDa
Source cDNA obtained from human leukocyte mRNA expressed in E.coli
Purity > 95% by SDS-PAGE stained by Coomassie Blue 
Bioactivity Measured using a cytopathic inhibition assay on Bovine Kidney Cells (MDBK) with Vesicular Stomatis Virus (VSV); human lung carcinoma cell line A549 with encephalomyocarditis virus (EMCV)
Storage For retention of full activity store at -70 ºC or below and avoid repeated freeze-thaw cycles
Synonyms Hu-IFN-α21
Accession Number V00540

Tech Info & Data

Application Note


  • A Comparison of the Binding of IFN-Alpha Subtypes to Isolated IFNAR1 and IFNAR2 with Activity in Antiviral and Antiproliferative Assays (link)


4 Citations


  1. Li, Y.,et al., (2023), "An Extracellular Humanized IFNAR Immunocompetent Mouse Model for Analyses of Human Interferon Alpha and Subtypes", Emerg Microbes Infect. 2287681. PMID: 37994664, DOI: 10.1080/22221751.2023.2287681 (link)

  2. Wilson, Timothy R, et al. (2012). Widespread potential for growth-factor-driven resistance to anticancer kinase inhibitors. Nature, 12 pgs. PMID: 22763448. (link)

  3. Kang, Dong-Chul, et al. (2004). Expression Analysis and Genomic Characterization of Human Melanoma Differentiation Associated Gene-5, mda-5: a Novel Type I Interferon-Responsive Apoptosis-Inducing Gene. Oncogene, 12 pgs. PMID: 14676839. (link)

  4. Hilkens, Catharien, et al. (2003). Differential responses to IFN-alpha subtypes in human T cells and dendritic cells. Journal of Immunology, 10 pgs. PMID: 14607926. (link)


Certificate of Analysis (CoA) and Safety Data Sheet (SDS)
11130-1 CoA

11130-1 Certificate of Analysis (CoA)

11130 SDS

11130 Safety Data Sheet