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Human IFN-Alpha I (Alpha 17)

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Human IFN-Alpha I (Alpha 17)

Catalog Number: 11150

Human Interferon Alpha 17 recombinant protein expressed in E.coli

$335.00

Pack Size
Product Info

Recombinant Human Interferon Alpha I (alpha 17) obtained from human leukocyte mRNA expressed in E.coli.

 

IFN alpha 17 is one of the many interferon alpha subtypes belonging to the Type I leukocyte IFN family.  The Type I IFN family has antiviral, anti-proliferative, and natural killer cell activities.

 

 

  • Expression induced by viral infection
  • Encoding gene IFNA17

Specifications

Formulation Supplied frozen in phosphate-buffered saline (PBS) containing 0.1% Bovine Serum Albumin (BSA)
Molecular Weight 19.3 kDa
Source cDNA obtained from human leukocyte mRNA expressed in E.coli
Purity > 95% by SDS-PAGE stained by Coomassie Blue
Bioactivity Measured using a cytopathic inhibition assay on Bovine Kidney Cells (MDBK) with Vesicular Stomatis Virus (VSV); human lung carcinoma cell line A549 with encephalomyocarditis virus (EMCV)
Storage

For retention of full activity store at -70 ºC or below and avoid repeated freeze-thaw cycles

Synonyms Hu-IFN-α17
Accession Number V00532

Tech Info & Data

Application Note

 

  • A Comparison of the Binding of IFN-Alpha Subtypes to Isolated IFNAR1 and IFNAR2 with Activity in Antiviral and Antiproliferative Assays (link)

Citations

4 Citations

 

  1. Smith, et al. (2019). Control of TLR7-mediated type I IFN signaling in pDCs through CXCR4 engagement-A new target for lupus treatment. Science Advances, 14 pgs. PMID: 31309143. (link)

  2. Reynolds, et al. (2019). Type I interferon in patients with systemic autoimmune rheumatic disease is associated with haematological abnormalities and specific autoantibody profiles. Arthritis Research & Therapy, 12 pgs. PMID: 31200750. (link)

  3. Wilson, Timothy R, et al. (2012). Widespread potential for growth-factor-driven resistance to anticancer kinase inhibitors. Nature, 12 pgs. PMID: 22763448. (link)

  4. Kang, Dong-Chul, et al. (2004). Expression Analysis and Genomic Characterization of Human Melanoma Differentiation Associated Gene-5, mda-5: a Novel Type I Interferon-Responsive Apoptosis-Inducing Gene. Oncogene, 12 pgs. PMID: 14676839. (link)

Documentation

Certificate of Analysis (CoA) and Safety Data Sheet (SDS)
11150-1 CoA

11150-1 Certificate of Analysis (CoA)

11150 SDS

11150 Safety Data Sheet