Universal Type I IFN-Alpha is a unique hybrid interferon constructed from recombinant human interferons alpha A and alpha D (Human IFN-Alpha A/D [BglII]). Activity has been observed on many mammalian cells, including human, monkey, mouse, bovine, rat, cat, pig, rabbit, guinea pig, or hamster.

This product is useful for cross-species testing with interferon or for species where autologous interferon is not available. Crucial for cross-species comparative studies in virology, immune modulation, and more.

91 Citations:

1. Shu, J., et al., (2023), "Zika virus infection triggers caspase cleavage of STAT1", Microbiol Spectr., e0360923, PMID: 38018976, DOI: 10.1128/spectrum.03609-23 (link)


2. Khatun, O., et al., (2023), "SARS-CoV-2 ORF6 protein targets TRIM25 for proteasomal degradation to diminish K63-linked RIG-I ubiquitination and type-I interferon induction", Cell Mol Life Sci., 80(12):364, PMID: 37982908, DOI: 10.1007/s00018-023-05011-3 (link)


3. van Tol, S. et al., (2023), "Pteropus vampyrus TRIM40 Is an Interferon-Stimulated Gene That Antagonizes RIG-I-Like Receptors", Viruses, 15(11):2147, DOI: 10.3390/v15112147 (link)


4. Chen, C. et al., (2023), "A novel highly selective allosteric inhibitor of tyrosine kinase 2 (TYK2) can block inflammation- and autoimmune-related pathways", Cell Commun Signal, 21(1):287, PMID: 37845748, DOI: 10.1186/s12964-023-01299-7 (link)


5. Haas, K.M., et al., (2023), "Proteomic and genetic analyses of influenza A viruses identify pan-viral host targets", Nat Commun. 14(1):6030, PMID: 37758692, DOI: 10.1038/z41467-023-41442-z (link)


6. Kastenschmidt, J.M., et al., (2023), "Influenza vaccine format mediates distinct cellular and antibody responses in human immune organoids", Immunity, S1074-7613(23):00276-5, PMID: 37478854, DOI: 10.1016/j.immuni.2023.06.019 (link)


7. Lei, Y. et al., (2023), "Cooperative sensing of mitochondrial DNA by ZBP1 and cGAS promotes cardiotoxicity", Cell, S0092-8674(23)00591-3, PMID: 37352855, DOI: 10.1016/j.cell.2023.02.039 (link)


8. Barnard, T.R. et al., (2023), "Zika virus NS3 and NS5 proteins determine strain-dependent differences in dsRNA accumulation in a host cell type-dependent manner", J Gen Virol., 104(6):001855, PMID: 37289497, DOI: 10.1099/jgv.0.001855 (link)


9. Duvvuri, B. et al., (2023), "Role of mitochondria in the myopathy of juvenile dermatomyositis and implications for skeletal muscle calcinosis", J. Autoimmun., 138:103061, PMID: 37244073, DOI: 10.1016/j.jaut.2023.103061 (link)


10. Philippot, Q., et al., (2023), "Autoantibodies Neutralizing Type I IFNs in the Bronchoalveolar Lavage of at Least 10% of Patients During Life-Threatening COVID-19 Pneumonia", J Clin Immunol., PMID: 37209324, DOI: 10.1007/s10875-023-01512-9 (link)


11. Wong, TL et al., (2023), "ADAR1-mediated RNA editing of SCD1 drives drug resistance and self-renewal in gastric cancer", Nat Commun., 14(1):2861, PMID: 37208334, DOI: 10.1038/s41467-023-38581-8 (link)


12. Hardy, A. et al., (2023), "The Timing and Magnitude of the Type I Interferon Response Are Correlated with Disease Tolerance in Arbovirus Infection", mBio, PMID: 37097030, DOI: 10.1128/mbio.00101-23 (link)


13. Pawlak, J.B. et al., (2023), "CMPK2 restricts Zika virus replication by inhibiting viral translation", PLoS Pathog., 19(4):e1011286, PMID: 37075076, DOI: 10.1371/journal.ppat.1011286 (link)


14. Wang, R. et al. (2023), "Characterization of the Impact of Merkel Cell Polyomavirus-Induced Interferon Signaling on Viral Infection", J. Virol., e0190722, PMID: 36946735, DOI: 10.1128/jvi.01907-22 (link)


15. Jacquet, S. et al., (2022), "Adaptive duplication and genetic diversification of protein kinase R contribute to the specificity of bat-virus interactions", Sci. Adv., 8(47):eadd7540, PMID: 36417524, DOI: 10.1126/sciadv.add7540 (link)


16. Naesens, L., et al., (2022), "GTF3A mutations predispose to herpes simplex encephalitis by disrupting biogenesis of the host-derived RIG-I ligand RNA5SP141", Sci. Immunol., 7(77):eabq4531, DOI: 10.1126/sciimmunol.abq4531 (link)


17. Aschenbrenner, D., et al., (2022), "Pathogenic Interleukin-10 Receptor Alpha Variants in Humans - Balancing Natural Selection and Clinical Implications", J. Clin. Immunol., PMID: 36370291, DOI: 10.1007/s10875-022-01366-7 (link)


18. Manolakou, T. et al.,  (2022), "ATR-mediated DNA damage responses underlie aberrant B cell activity in systemic lupus erythematosus", Sci. Adv., 8(43):eabo5840, PMID: 36306362, DOI: 10.1126/sciadv.abo5840 (link)


19. Kedarinath, K. et al., (2022), "CD24 Expression Sampens the Basal Antiviral State in Human Neuroblastoma Cells and Enhances Permissivity to Zika Virus Infection", Viruses, 14:1735, DOI: 10.3390/v14081735 (link)


20. Sato, Y. et al., (2022), "Epstein-Barr virus tegument protein BGLF2 in exosomes released from virus-producing cells facilitates de novo infection", Cell Commun. SIgnal., 20(1):95, PMID: 35729616, DOI: 10.1186/s12964-022-00902-7 (link)


21. Lutz, K. et al., (2022), "Ly6D+Siglec-H+ precursors contribute to conventional dendritic cells via a Zbtb46+Ly6D+ intermediary stage", Nat. Commun., 13(1):3456, PMID: 35705536, DOI: 10.1038/s41467-022-31054-4 (link)


22. Manokaran, G. et al., (2022), "Deactivation of the antiviral state by rabies virus through targeting and accumulation of persistently phosphorylated STAT1", PLoS Pathogens, 18(5):e1010533, PMID: 35576230, DOI: 10.1371/jpurnal.ppat.1010533 (link)


23. Kedarinath, K. and Parks, G. D., (2022), "Differential In Vitro Growth and Cell Killing of Cancer versus Benign Prostate Cells by Oncolytic Parainfluenza Virus", Pathogens, 11(5):493, DOI: 10.3390/pathogens11050493 (link)


24. Gnatenko, D., et al., (2022), "Cytokine pathway variants modulate platelet production: IFNA16 is a thrombocytosis susceptibility locus in humans", Blood Advances, PMID: 35381074, DOI: 10.1182/bloodadvances.2021005648 (link)


25. Cheng, CW. et al., (2022), "The pathogenic role of IFN-a in thyroiditis mouse model", Life Sciences, 288:120172, DOI: 10.1016/j.lfs.2021.120172 (link)


26. Ka, N., et al.,  (2021), "IFI16 inhibits DNA repair that potentiates type-I interferon-induced antitumor effects in triple negative breast cancer", Cell Reports, 37:110138, DOI: 10.1016/j.celrep.2021.110138 (link)


27. Amat, J.A.R. et al., (2021), "Long-term adaptation following influenza A virus host shifts results in increased within-host viral fitness due to higher replication rates, broader dissemination within the respiratory epthelium and reduced tissue damage", PLoS Pathog., 17(12):e1010174, DOI: 10.1371/journal.ppat.1010174 (link)


28. Brunn, D. et al.,  (2021), "Interferon Regulatory Factor 9 Promotes Lung Cancer Progression via Regulation of Versican", Cancers, 13:208, PMID: 33430083, DOI: 10.3390/cancers13020208 (link)


29. Liu W, et al. (2021) Activation of STING signaling pathway effectively blocks human 1 coronavirus infection. American Society for Microbiology (link)


30. Rebendenne A, et al. (2021) SARS-CoV-2 triggers an MDA-5-dependent interferon response which is unable to 1control replication in lung epithelial cells. American Society for Microbiology, PMID: 33514628 (link)


31. Cheng, J., et al., (2021), "IL-27 induces IFN/STAT1-dependent genes and enhances function of TIGIT+ HIVGag-specific T cells", iScience, 25:103588, DOI: 10.1016/j.isci.2021.103588. (link)


32. Shu, J. et al., (2021), "NS5-Independent Ablation of STAT2 by Zika virus to antagonize interferon signalling", Emerging Microbes & Infections, 10:1601, DOI: 10.1080/22221751.2021.1964384 (link)


33. Zhan, J., et al., (2021), "Definition of the immune evasion-replication interface of rabies virus P protein", PLoS Patho, 17(7):e1009729, DOI: 10.1371/journal.ppat.1009129 (link)


34. Hsu, JJC., et al., (2021), "Translational shutdown and evasion of the innate immune response by SARS-CoV-2 NSP14 protein", PNAS, 118(24)e2101161118, DOI: 10.1073/pnas.2101161118


35. Felgenhauer U, et al. (2020) Inhibition of SARS-CoV-2 by Type I and Type III Interferons. Journal of Biological Chemistry, PMID: 32587093. (link)


36. Roesch F and OhAinle M. (2020) HIV-CRISPR: A CRISPR/Cas9 Screening Method to Identify Genes Affecting HIV Replication. Bio-Protocol (link)


37. Satterfield, Benjamin, et al. (2019). Antagonism of STAT1 by Nipah virus P gene products modulates disease course but not lethal outcome in the ferret model. Scientific Reports, 18 pgs. PMID: 31723221. (link)


38. Kim, Jeong Jin, et al. (2019). Viperin Differentially Induces Interferon-Stimulated Genes in Distinct Cell Types. Immune Network, 16 pgs. PMID: 31720044. (link)


39. Heilmann, Emmanuel, et al. (2019). The Methyltransferase Region of Vesicular Stomatitis Virus L Polymerase Is a Target Site for Functional Intramolecular Insertion. Viruses, 18 pgs. PMID: 31717818. (link)


40. Wang, Peng, et al. (2019). IL-36 promotes anti-viral immunity by boosting sensitivity to IFN-α/β in IRF1 dependent and independent manners. Nature Communications, 17 pgs. PMID: 31619669. (link)


41. Vannini, Andrea, et al. (2019). αvβ3-integrin regulates PD-L1 expression and is involved in cancer immune evasion. PNAS, 11 pgs. PMID: 31527243. (link)


42. Chen, Jianzhou, et al. (2019). Type I IFN protects cancer cells from CD8+ T cell–mediated cytotoxicity after radiation. JCI, 16 pgs. PMID: 31483286. (link)


43. Robison, Amanda, et al. (2019). Expression of human TLR4/myeloid differentiation factor 2 directs an early innate immune response associated with modest increases in bacterial burden during Coxiella burnetii infection. Innate Immunity, 11 pgs. PMID: 31180798. (link)


44. Grunewald, Matthew, et al. (2019). The coronavirus macrodomain is required to prevent PARP-mediated inhibition of virus replication and enhancement of IFN expression. PLOS Pathogens, 24 pgs. PMID: 31095648. (link)


45. Rigby, Rachel, et al. (2019). PA-X antagonises MAVS-dependent accumulation of early type I interferon messenger RNAs during influenza A virus infection. Scientific Reports, 13 pgs. PMID: 31076606. (link)


46. Hossain, et al. (2019). Structural Elucidation of Viral Antagonism of Innate Immunity at the STAT1 Interface. Cell Reports, 21 pgs. PMID: no PMID. (link)


47. Uccellini, Melissa, et al. (2018). ISRE-Reporter Mouse Reveals High Basal and Induced Type I IFN Responses in Inflammatory Monocytes. Cell Reports, 17 pgs. PMID: 30517866. (link)


48. Pfaller, Christian, et al. (2018). Extensive Editing of Cellular and Viral Double-Stranded RNA Structures Accounts for Innate Immunity Suppression and the Proviral Activity of ADAR1^(p150). PLOS Biology, 36 pgs. PMID: 30496178. (link)


49. Gkirtzimanaki, Katerina, et al. (2018). IFN-Alpha Impairs Autophagic Degradation of mtDNA Promoting Autoreactivity of SLE Monocytes in a STING-Dependent Fashion. Cell Reports, 19 pgs. PMID: 30355498. (link)


50. Muth, Doreen, et al. (2018). Attenuation of Replication by a 29 Nucleotide Deletion in SARS-Coronavirus Acquired During the Early Stages of Human-to-Human Transmission. Scientific Reports, 11 pgs. PMID: 30310104. (link)


51. Kruger, Nadine, et al. (2018). Entry, Replication, Immune Evasion, and Neurotoxicity of Synthetically Engineered Bat-Borne Mumps Virus. Cell Reports, 17 pgs. PMID: 30304672. (link)


52. Carlin, Aaron, et al. (2018). Deconvolution of Pro- and Antiviral Genomic Responses in Zika Virus-Infected and Bystander Macrophages. PNAS, 10 pgs. PMID: 30206152. (link)


53. Vahedi, et al. (2018). IL-15 and IFN-γ signal through the ERK pathway to inhibit HCV replication, independent of type I IFN signaling. Cytokine. PMID: 29908921. (link)


54. Matsuno, Keita, et al. (2018). The Unique Phylogenetic Position of a Novel Tick-Borne Phlebovirus Ensures an Ixodid Origin of the Genus Phlebovirus. mSphere, 14 pgs. PMID: 29898985. (link)


55. Cytlak, Urszula, et al. (2018). Ikaros family zinc finger 1 regulates dendritic cell development and function in humans. Nature Communications, 10 pgs. PMID: 29588478. (link)


56. Rose, Elaine (2018). Identifying Mechanisms of Resistance to Oncolytic Virotherapy in Acute Leukemia Through a Genome-Wide CRISPR Screen. University of Ottawa, 108 pgs. PMID: no PMID. (no link)


57. Dai, Xiuju, et al. (2017). Epidermal keratinocytes sense dsRNA via the NLRP3 inflammasome, mediating interleukin (IL)-1β and IL-18 release. Experimental Dermatology. PMID: 28266737. (link)


58. Chen, et al. (2016). Carcinoma-astrocyte gap junctions promote brain metastasis by cGAMP transfer. Nature, 34 pgs. PMID: 27225120. (link)


59. Hedges, Jodi, et al. (2016). Type I Interferon Counters or Promotes Coxiella burnetii Replication Dependent on Tissue. Infection and Immunity, 11 pgs. PMID: 27068091. (link)


60. Labzin, Larisa I, et al. (2015). ATF3 Is a Key Regulator of Macrophage IFN Responses. Journal of Immunology, 11 pgs. PMID: 26416280. (link)


61. Berri, Fatma, et al. (2014). Annexin V incorporated into influenza virus particles inhibits gamma interferon signaling and promotes viral replication. JVI, 14 pgs. PMID: 25031344. (link)


62. Cimica, Velasco, et al. (2014). An innate immunity-regulating virulence determinant is uniquely encoded by the Andes virus nucleocapsid protein. mBio, 10 pgs. PMID: 24549848. (link)


63. Li, et al. (2014). RIG-I modulates Src-mediated AKT activation to restrain leukemic stemness. CellPress. PMID: 24412064. (link)


64. Wang, Tao, et al. (2014). SECTM1 produced by tumor cells attracts human monocytes via CD7-mediated activation of the PI3K pathway. JID, 22 pgs. PMID: 24157461. (link)


65. Li, Wen, et al. (2013). Regulation of development of CD56 bright CD11c + NK-like cells with helper function by IL-18. PLOS One, 12 pgs. PMID: 24376549. (link)


66. Webster, Brian, et al. (2013). Evasion of superinfection exclusion and elimination of primary viral RNA by an adapted strain of hepatitis C virus. JVI, 16 pgs. PMID: 24089557. (link)


67. Jones, Philip H, et al. (2013). BST-2/tetherin-mediated restriction of chikungunya (CHIKV) VLP budding is counteracted by CHIKV non-structural protein 1 (nsP1). Virology, 28 pgs. PMID: 23411007. (link)



























 
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93. Dionne, et al. (2013). Daxx Upregulation within the Cytoplasm of Reovirus-Infected Cells is Mediated by Interferon and Contributes to Apoptosis. JVI, 14 pgs. PMID: 23302889. (link)


94. Lochhead, et al. (2012). Endothelial Cells and Fibroblasts Amplify the Arthritogenic Type I IFN Response in Murine Lyme Disease and are Major Sources of Chemokines in Borrelia burgdorferi-Infected Joint Tissue. Journal of Immunology, 34 pgs. PMID: 22851707. (link)


95. Wilson, Timothy R, et al. (2012). Widespread potential for growth-factor-driven resistance to anticancer kinase inhibitors. Nature, 12 pgs. PMID: 22763448. (link)


96. Curtsinger, et al. (2012). Autocrine IFN-gamma Promotes Naive CD8 T Cell Differentiation and Synergizes with IFN-alpha to Stimulate Strong Function. Journal of Immunology, 21 pgs. PMID: 22706089. (link)


97. Marozin, et al. (2012). Posttranslational Modification of Vesicular Stomatitis Virus Glycoprotein, but Not JNK Inhibition, is the Antiviral Mechanism of SP600125. JVI, 12 pgs. PMID: 22345438. (link)


98. Cilloniz, Cristian, et al. (2012). Molecular signatures associated with Mx1-mediated resistance to highly pathogenic influenza virus infection: mechanisms of survival. JVI, 10 pgs. PMID: 22190720. (link)


99. Varga, et al. (2011). The Influenza Virus Protein Pb1-F2 Inhibits the Induction of Type 1 Interferon at the Level of the MAVS Adaptor Protein. PLOS Pathogens, 16 pgs. PMID: 21695240. (link)


100. Knoblach, Theresa, et al. (2011). Human cytomegalovirus IE1 protein elicits a type II interferon-like host cell response that depends on activated STAT1 but not interferon-γ. PLOS Pathogens, 24 pgs. PMID: 21533215. (link)


101. Meunier and von Messling, et al. (2011). NS1-Mediated Delay of Type 1 Interferon Induction Contributes to Influenza A Virulence in Ferrets. Journal of General Virology, 10 pgs. PMID: 21411677. (link)


102. Carlos, TS, et al. (2009). Parainfluenza virus 5 genomes are located in viral cytoplasmic bodies whilst the virus dismantles the interferon-induced antiviral state of cells. Journal of General Virology, 10 pgs. PMID: 19458173. (link)


103. Ahmed, Maryam, et al. (2009). Vesicular Stomatitis Virus M Protein Mutant Stimulates Maturation of Toll-Like Receptor 7 (TLR7)-Positive Dendritic Cells through TLR-Dependent and -Independent Mechanisms. JVI, 14 pgs. PMID: 19144711. (link)


104. Albanesi, Cristina, et al. (2009). Chemerin expression marks early psoriatic skin lesions and correlates with plasmacytoid dendritic cell recruitment. JEM, 10 pgs. PMID: 19114666. (link)


105. Carthagena, et al. (2008). Implications of TRIMalpha and TRIMcyp in Interferon-Induced Anti-Retroviral Restriction Activities. Retrovirology, 15 pgs. PMID: 18613956. (link)


106. Han, Jian-Qiu, et al. (2007). A Phylogenetically Conserved RNA Structure in the Poliovirus Open Reading Frame Inhibits the Antiviral Endoribonuclease RNase L. JVI, 12 pgs. PMID: 17344297. (link)


107. Ye, Ye, et al. (2007). Mouse Hepatitis Coronavirus A59 Nucleocapsid Protein Is a Type I Interferon Antagonist. JVI, 10 pgs. PMID: 17182678. (link)


108. Pejawar, Sharmila, et al. (2005). Abortive versus Productive Viral Infection of Dendritic Cells with a Paramyxovirus Results in Differential Upregulation of Select Costimulatory Molecules. JVI, 14 pgs. PMID: 15919909. (link)


109. Curtsinger, Julie, et al. (2005). Type I IFNs provide a third signal to CD8 T cells to stimulate clonal expansion and differentiation. Journal of Immunology, 6 pgs. PMID: 15814665. (link)


110. Kambayashi, Taku, et al. (2003). Memory CD8+ T cells provide an early source of IFN-gamma. Journal of Immunology, 11 pgs. PMID: 12594263. (link)


111. Sainz, Bruno, et al. (2002). Alpha/Beta Interferon and Gamma Interferon Synergize To Inhibit the Replication of Herpes Simplex Virus Type 1. JVI, 10 pgs. PMID: 12388715. (link)


112. Weber, Friedemann, et al. (2002). Bunyamwera Bunyavirus Nonstructural Protein NSs Counteracts the Induction of Alpha/Beta Interferon. JVI, 7 pgs. PMID: 12133999. (link)


113. McNally, James, et al. (2001). Attrition of Bystander CD8 T Cells during Virus-Induced T-Cell and Interferon Responses. JVI, 12 pgs. PMID: 11390598. (link)


114. Doughty, Lesley, et al. (2001). A role for IFN-alpha beta in virus infection-induced sensitization to endotoxin. Journal of Immunology, 8 pgs. PMID: 11160329. (link)


115. Abe, Shuzo, et al. (1999). Effects of chronic administration of interferon alpha A/D on serotonergic receptors in rat brain. Neurochemical Research, 5 pgs. PMID: 10215509. (link)


116. Sperber, Steven, et al. (1992). Anti-HIV-1 activity of recombinant and hybrid species of interferon-alpha. Journal of Interferon Research, 6 pgs. PMID: 1331260. (link)