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Catalog No. | Pack Size | Price | Quantity |
---|---|---|---|
12100-1 |
1 x 105 units |
$425.00 |
Formulation | Supplied frozen in phosphate-buffered saline (PBS) containing 0.1% Bovine Serum Albumin (BSA) |
Molecular Weight | 19.3 kDa |
Source | cDNA obtained from mouse leukocyte interferon expressed in E.coli |
Purity | > 95% by SDS-PAGE stained by Coomassie Blue Endotoxin level < 1 EU/μg |
Bioactivity | Measured using a cytopathic inhibition assay on Mouse (L929) cells with EMCV. EC50 for IFN Alpha A in this assay is ~ 5 U/ml. |
Storage | For retention of full activity store at -70°C or below and avoid repeated freeze/thaw cycles |
Synonyms | Mouse Interferon Alpha, IFNA3, Interferon Alpha 3, IFNA, IFN-alpha A |
Accession Number | NP_996753 |
For more information on Mouse IFN Alpha subtype nomenclature click here.
Most mammalian species have multiple IFN-alpha subtypes. Although the reasons for these multiple subtypes are not fully known, there are clear cell type and temporal differences in their expression. A recent study established a nomenclature for the mouse IFN-alpha subtypes (van Pesch, et al. 2004) and determined relative activities of the subtypes with protein quantification by phosphorimaging of metabolically-labeled protein. In this study, Mouse IFN-alpha A was deemed to have average antiviral activity when compared with the potency of the other subtypes.
Mouse IFN-alpha A was initially cloned by Daugherty, et al. (1984) J. Interferon Res. 4(4) 635]. Being the first commercially available Mouse IFN-alpha protein, it has been used extensively in published research reports. Expression of this subtype has been observed in neurons infected with Theiler’s virus [Delhaye, et al. (2006) PNAS 103(20)7835]. Additionally, the protein has been shown to sensitize lymphocytes to undergo apoptosis [Cuerro, et al. (2004) J. Exp. Med. 200(4)535] and enhance the proliferation and differentiation of CD8 T-cells [Curtsinger, et al. (2005) J. Immunol. 174(8) 4465]. Furthermore, it was used to determine that B10.Q/J mice are susceptible to infection due to a Tyk2 mutation [Shaw, et al.(2003) PNAS 100(20)11594]. Hardy, et al. [Genomics (2004) 84:331] recently suggested a name of IFN Alpha 3 based on sequence comparison of the Mouse IFN-alpha subtype family of proteins.
41 Citations:
References: (For additional references, please refer to the certificate of analysis)
The activity of Mouse IFN Alpha A and Mouse IFN Alpha 4 was compared in an L929/EMCV CPE assay. The EC50 for Mouse Alpha A in this experiment was 54 pg/ml.
Results are representative and may vary depending upon experimental conditions.
Catalog No. | Description | Pack Size | Price | Quantity |
---|---|---|---|---|
12105-1 |
Mouse Interferon Alpha 1 |
1 x 105 units |
$385.00 |
|
12115-1 |
Mouse Interferon Alpha 4, mammalian |
1 x 105 units |
$385.00 |
|
22100-1 |
Anti-Mouse Interferon Alpha, Clone RMMA-1 (MAb) |
250 μg |
$515.00 |
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PBL Assay Science offers scientists a comprehensive range of assay kits, interferons, cytokines, growth factors and antibodies. Our high quality products provide consistent, reliable performance and are suitable for use in a range of research applications.
Quick Search
PBL’s improved site search function is defaulted to an exact match.
Search Term Results |
|
IFN beta |
All interferon beta products and related technical information (e.g. technical notes) |
Human IFN beta |
All human interferon products related technical information (e.g. technical notes) |
IL-2 |
All products contain the term “IL-2”, including IL-23 |
IL 2 |
All products contain the term “IL 2”, including IL-23 |
Erythropoietin |
All EPO products and technical information |
Eryth |
All EPO products and technical information |
The results are displayed in best match products grouped in the following product category filters:
Each filter contains sub-categories for further narrowing of your search results
Other web content such as technical notes that contain the Search Term can be displayed by checking the box next to the corresponding filter on the left side of the Search Results Page.