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Catalog No. | Pack Size | Price | Quantity |
---|---|---|---|
12115-1 |
1 x 105 units |
$385.00 |
Formulation | Supplied frozen in phosphate-buffered saline (PBS) containing 0.1% Bovine Serum Albumin (BSA) |
Molecular Weight | 19.5 kDa |
Source | Gene obtained from Murine (C57/BI) DNA expressed in mammalian cells |
Purity | > 95% by SDS-PAGE stained by Coomassie Blue Endotoxin level < 1 EU/μg |
Bioactivity | Measured using a cytopathic inhibition assay on Mouse (L929) cells with EMCV. The EC50 for IFN in this assay is ~ 5 U/ml. |
Storage | For retention of full activity store at -70oC or below and avoid repeated freeze/thaw cycles |
Synonyms | Mu IFN-α4, Mouse IFN Alpha Subtype, Mouse IFN Protein Subtype, Interferon Alpha, IFN Alpha, IFN-a, Type I IFN Alpha |
Accession Number | NM_010504 |
Mouse IFN Alpha 4 was initially cloned by Zwarthoff et al. [(1985) Nuc. Acids Res. 13(3)791], and has been extensively studied. It is apparently expressed early in viral infection in a protein synthesis independent manner, and its expression is induced by phosphorylation of IRF-3. It may be that Mouse IFN Alpha 4, like IFN Beta, has a priming function on cells, enabling the expression of other Mouse IFN Alpha subtypes [Review by Mesplede et al., (2003) Autoimmunity 36(8):447 and Asselin-Paturel & Trinchieri (2005) J. Exp. Med. 202(4):461]. Thus, this interferon is among the first observed after viral infection. Intriguingly, while this interferon is expressed in a large variety of cell types, one report suggests that the expression level in dendritic cells is low to non-existent [Barchet et al., (2002) J. Exp. Med. 195(4):507].
Summary: Mouse IFN Alpha 4 is a widely expressed mouse interferon alpha which may play a role in preparing cells to express high levels of other mouse interferon alpha subtypes upon viral infection.
For more information on Mouse IFN Alpha subtype nomenclature click here.
6 Citations:
References:
Catalog No. | Description | Pack Size | Price | Quantity |
---|---|---|---|---|
12100-1 |
Mouse Interferon Alpha A |
1 x 105 units |
$425.00 |
|
12105-1 |
Mouse Interferon Alpha 1 |
1 x 105 units |
$385.00 |
|
22100-1 |
Anti-Mouse Interferon Alpha, Clone RMMA-1 (MAb) |
250 μg |
$515.00 |
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PBL Assay Science offers scientists a comprehensive range of assay kits, interferons, cytokines, growth factors and antibodies. Our high quality products provide consistent, reliable performance and are suitable for use in a range of research applications.
Quick Search
PBL’s improved site search function is defaulted to an exact match.
Search Term Results |
|
IFN beta |
All interferon beta products and related technical information (e.g. technical notes) |
Human IFN beta |
All human interferon products related technical information (e.g. technical notes) |
IL-2 |
All products contain the term “IL-2”, including IL-23 |
IL 2 |
All products contain the term “IL 2”, including IL-23 |
Erythropoietin |
All EPO products and technical information |
Eryth |
All EPO products and technical information |
The results are displayed in best match products grouped in the following product category filters:
Each filter contains sub-categories for further narrowing of your search results
Other web content such as technical notes that contain the Search Term can be displayed by checking the box next to the corresponding filter on the left side of the Search Results Page.