Anti-Human IFN-Alpha, Clone MMHA-2 (MAb)
Catalog Number: 21100
Unconjugated Anti-Human IFN-Alpha antibody with high binding affinity (KA ~ 109 M-1) to human Interferon Alpha suitable for use in Neutralization, ELISA, and Western Blot.
$395.00
Product Info
Specificity
Neutralizes human IFN-Alpha; binds to human IFN-Alpha with high affinity (KA~ 109 M-1)
Tested Applications
Specifications
| Formulation | Product 21100-1 supplied frozen in phosphate-buffered saline (PBS) containing 0.1% Bovine Serum Albumin (BSA) Product 21100-2 supplied frozen in 18mM Citric Acid; 165 mM Sodium Phosphate Dibasic pH 7.0 without Bovine Serum Albumin (BSA) |
|---|---|
| Antigen | Human leukocyte interferon |
| Isotype | IgG1 kappa |
| Host Species | Mouse |
| Purity | > 95% by SDS-PAGE stained by Coomassie Blue Endotoxin level < 1 EU/μg |
| Bioactivity | Measured by neutralization of interferon in cytopathic effect inhibition assay. |
| Storage | For retention of full activity store at -70°C or below and avoid repeated freeze/thaw cycles |
| Antigen Synonyms | IFN alpha MAb, IFN-a, interferon alpha monoclonal, IFN alpha 2, IFN-a2, interferon alpha 2, Leukocyte interferon, Leukocyte IFN, alpha interferon, interferon alfa, IFN alfa, interferon alpha 2a, IFN alpha 2a, interferon a, interferon alpha 2b, IFN alpha 2b, Type I interferon alpha, Type I IFN alpha Clone MMHA-2 |
| Clone | MMHA-2 |
Tech Info & Data
Tips, Tools and Troubleshooting
- Antibodies against Human IFN-α Subtype Specificities Comparison Chart (link)
Citations
13 Citations
- Rosa, TLSA et al., (2022), "The Type I Interferon Pathway Is Upregulated in the Cutaneous Lesions and Blood Multibacillary Leprosy Patients With Erythema Nodosum Leprosum", Front. Med., 9:899998, PMID: 35733868, DOI: 10.3389/fmed.2022.899998 (link)
- Uebele, Julia, et al. (2017). Antigen delivery to dendritic cells shapes human CD4+ and CD8+ T cell memory responses to Staphylococcus aureus. PLOS Pathogens, 23 pgs. PMID: 28542586. (link)
- Gupta, Sachin, et al. (2016). Constitutively Active MAVS Inhibits HIV-1 Replication via Type I Interferon Secretion and Induction of HIV-1 Restriction Factors. PLOS One, 25 pgs. PMID: 26849062. (link)
- Tsugawa, et al. (2014). Critical Role of Interferon-alpha Constitutively Produced in Human Hepatocytes in Response to RNA Virus Infection. PLOS One, 9 pgs. PMID: 24587086. (link)
- Woo, et al. (2013). Developmental Differences in IFN Signaling Affect GATA1s-Induced Megakaryocyte Hyperproliferation. JCI, 14 pgs. PMID: 23863621. (link)
- Genesca, et al. (2012). Live-Attenuated Lentivirus Immunization Modulates Innate Immunity and Inflammation While Protecting Rhesus Macaques from Vaginal Simian Immunodeficiency Virus Challenge. JVI, 13 pgs. PMID: 22696662. (link)
- Liu, et al. (2012). Influenza A Virus Induces Interleukin-27 Through Cyclooxygenase-2 and Protein Kinase A Signaling. JBC, 12 pgs. PMID: 22343630. (link)
- Zhan, Sabine, et al. (2011). Evidence for a pathophysiological role of keratinocyte-derived type III interferon (IFNλ) in cutaneous lupus erythematosus. JID, 8 pgs. PMID: 20720564. (link)
- Harris, Levelle, et al. (2010). Downregulation of Robust Acute Type I Interferon Responses Distinguishes Nonpathogenic Simian Immunodeficiency Virus (SIV) Infection of Natural Hosts from Pathogenic SIV Infection of Rhesus Macaques. JVI, 6 pgs. PMID: 20484518. (link)
- Moll, Herwig, et al. (2008). Neutralizing Type I Interferon Antibodies trigger an Interferon-Like Response in Endothelial Cells1. Journal of Immunology, 16 pgs. PMID: 18390705. (link)
- Fanning, Stacey, et al. (2006). Receptor cross-linking on human plasmacytoid dendritic cells leads to the regulation of IFN-alpha production. Journal of Immunology, 12 pgs. PMID: 17056507. (link)
- Chung, Eugene, et al. (2005). Characterization of Virus-Responsive Plasmacytoid Dendritic Cells in the Rhesus Macaque. Clinical and Diagnostic Laboratory Immunology, 10 pgs. PMID: 15753256. (link)
- Megjugorac, NJ, et al. (2004). Virally stimulated plasmacytoid dendritic cells produce chemokines and induce migration of T and NK cells. JLB. PMID: 14742635. (link)