Human IFN Beta 1b, E.coli

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Product Features: 
  • Human IFN Beta 1b, E.coli, recombinant protein
  • Type I IFN
  • Single non-glycosylated polypeptide chain, serine replace cysteine at residue 17

Ordering

Catalog No. Pack Size Price Quantity
11420-1

1 x 105 units

 $235.00

Specifications

Formulation Supplied frozen with a carrier protein
Molecular Weight 20 kDa
Source cDNA obtained from human fibroblast interferon beta mRNA expressed in E.coli
Purity > 95% by SDS-PAGE stained by Coomassie Blue
Endotoxin level < 1 EU/μg
Bioactivity Measured using a cytopathic inhibition assay on human lung carcinoma cell line A549 with encephalomyocarditis virus (EMCV). EC50 for IFN beta 1b in this assay is ~ 1 U/ml
Synonyms Human IFNB, Human Beta Interferon, Human IFN Beta 1b, Human Interferon beta 1b, Human Type I Interferon Beta, Human IFN B
Storage For retention of full activity store at -70°C or below and avoid repeated freeze/thaw cycles
Accession Number V00534

Citations

6 Citations:

  1. Fernbach, S. et al., (2022), "Restriction factor screening identifies RABGAP1L-mediated disruption of endocytosis as a host defense", Cell Reports, 38:110549, PMID: 35320721, DOI: 10.1016/j.celrep.2022.110549 (link)
  2. Nair, Sajith, et al. (2016). Global Functional Profiling of Human Ubiquitome Identifies E3 Ubiquitin Ligase DCST1 as a Novel Negative Regulator of Type-I Interferon Signaling. Scientific Reports, 13 pgs. PMID: 27782195. (link)

  3. Novatt, Hilary, et al. (2016). Distinct Patterns of Expression of Transcription Factors in Response to Interferon-beta and Interferon-gamma-1. Journal of Interferon & Cytokine Research, 10 pgs. PMID: 27447339. (link)

  4. Ambjorn, Malene, et al. (2016). IFNB1/Interferon-beta-Induced Autophagy in MCF-7 Breast Cancer Cells Counteracts its Proapoptotic Function. Autophagy, 17 pgs. PMID: 23221969. (link)

  5. Lim, Efrem, et al. (2009). Simian Immunodeficiency Virus SIV_agm From African green Monkeys Does Not Antagonize Endogenous Levels of African Green Monkey Tetherin/BST-2. JVI, 9 pgs. PMID: 19726508. (link)

  6. Barr, Stephen, et al. (2008). The Interferon Response Inhibits HIV Particle Production by Induction of TRIM22. PLOS Pathogens, 11 pgs. PMID: 18389079. (link)

Documentation

Human IFN Beta 1b, E.coli Titration in A549

Titration of Human Interferon Beta 1b, E.coli in the A549 Cell Line

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