Human IFN-Beta 1b, E.Coli
Catalog Number: 11420
Human Interferon Beta 1b, E.coli-expressed, recombinant protein.
$255.00
Product Info
Single non-glycosylated polypeptide chain, serine replaces cysteine at residue 17.
Specifications
| Formulation | Supplied frozen with a carrier protein |
|---|---|
| Molecular Weight | 20 kDa |
| Source | cDNA obtained from human fibroblast interferon beta mRNA expressed in E.coli |
| Purity | > 95% by SDS-PAGE stained by Coomassie Blue Endotoxin level < 1 EU/μg |
| Bioactivity | Measured using a cytopathic inhibition assay on human lung carcinoma cell line A549 with encephalomyocarditis virus (EMCV). EC50 for IFN beta 1b in this assay is ~ 1 U/ml |
| Synonyms | Human IFNB, Human Beta Interferon, Human IFN Beta 1b, Human Interferon beta 1b, Human Type I Interferon Beta, Human IFN B |
| Storage | For retention of full activity store at -70°C or below and avoid repeated freeze/thaw cycles |
| Accession Number | V00534 |
Citations
8 Citations:
- Li, Y.,et al., (2023), "An Extracellular Humanized IFNAR Immunocompetent Mouse Model for Analyses of Human Interferon Alpha and Subtypes", Emerg Microbes Infect. 2287681. PMID: 37994664, DOI: 10.1080/22221751.2023.2287681 (link)
- Iseli, A.N. et al., (2023), "The neuraminidase activity of influenza A virus determines the strain-specific sensitivity to neutralization by respiratory mucus", J. Virol., e0127123, PMID: 37819131, DOI: 10.1128/jvi.01271-23 (link)
- Fernbach, S. et al., (2022), "Restriction factor screening identifies RABGAP1L-mediated disruption of endocytosis as a host defense", Cell Reports, 38:110549, PMID: 35320721, DOI: 10.1016/j.celrep.2022.110549 (link)
- Nair, Sajith, et al. (2016). Global Functional Profiling of Human Ubiquitome Identifies E3 Ubiquitin Ligase DCST1 as a Novel Negative Regulator of Type-I Interferon Signaling. Scientific Reports, 13 pgs. PMID: 27782195. (link)
- Novatt, Hilary, et al. (2016). Distinct Patterns of Expression of Transcription Factors in Response to Interferon-beta and Interferon-gamma-1. Journal of Interferon & Cytokine Research, 10 pgs. PMID: 27447339. (link)
- Ambjorn, Malene, et al. (2016). IFNB1/Interferon-beta-Induced Autophagy in MCF-7 Breast Cancer Cells Counteracts its Proapoptotic Function. Autophagy, 17 pgs. PMID: 23221969. (link)
- Lim, Efrem, et al. (2009). Simian Immunodeficiency Virus SIV_agm From African green Monkeys Does Not Antagonize Endogenous Levels of African Green Monkey Tetherin/BST-2. JVI, 9 pgs. PMID: 19726508. (link)
- Barr, Stephen, et al. (2008). The Interferon Response Inhibits HIV Particle Production by Induction of TRIM22. PLOS Pathogens, 11 pgs. PMID: 18389079. (link)