Human IFN-Beta (Beta 1a, Mammalian Expressed)
Catalog Number: 11415
Recombinant Human IFN-Beta 1a, mammalian, protein expressed in CHO cells is useful for MS research studies.
$370.00
Product Info
Supplied frozen with a carrier protein for retention of full activity.
Specifications
| Formulation | 50 mM NaOAc, pH 5.5 containing 0.1% BSA |
|---|---|
| Molecular Weight | ~ 23 kDa |
| Source | cDNA obtained from human fibroblast interferon beta 1a mRNA expressed in CHO cells |
| Purity | > 95% by SDS-PAGE stained by Coomassie Blue Endotoxin level < 1 EU/μg |
| Bioactivity | Measured using a cytopathic inhibition assay on human lung carcinoma cell line A549 with encephalomyocarditis virus (EMCV). EC50 for IFN beta 1a in this assay is ~ 1 U/ml |
| Storage | For retention of full activity store at -70°C or below and avoid repeated freeze/thaw cycles |
| Synonyms | Human IFNB, Human Beta Interferon, Human IFN Beta 1a, Human Interferon beta 1a, Human Type I Interferon Beta, Human IFN B |
| Accession Number | V00534 |
Citations
35 Citations
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- Abt, E.R., et al., (2022), "Reprogramming of nucleotide metabolism by interferon confers dependence on the replication stress response pathway in pancreatic cancer cells", Cell Reports, 38:110236, DOI: 10.1016/j.celrep.2021.110236 (link)
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- Cheng, Quen, et al. (2019). Sequential conditioning-stimulation reveals distinct gene- and stimulus-specific effects of Type I and II IFN on human macrophage functions. Scientific Reports, 14 pgs. PMID: 30918279. (link)
- Subramaniam, Meena (2019). Implementing and Applying Multiplexed Single Cell RNA-sequencing to Reveal Context- specific Effects in Systemic Lupus Erythematosus. UCSF, 85 pgs. PMID: no PMID.
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- Mariani, Melissa, et al. (2018). RNASeq Analysis Identifies Non-Canonical Role of STAT2 and IRF9 in the Regulation of a STAT1-Independent Antiviral and Immunoregulatory Transcriptional Program Induced by IFN-Beta and TNF-Alpha. BioRxiv, 23 pgs. PMID: no PMID. (link)
- Lau, Alexander, et al. (2017). Prevalence of Neutralising Antibodies to interferon-Beta and Clinical Response in Chinese Patients with Relapsing Multiple Sclerosis. MSJ, 10 pgs. PMID: 29051830. (link)
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- Gao, Xioafei, et al. (2016). Citrobacter rodentium NleB Inhibits Tumor Necrosis Factor (TNF) Receptor-Associated Factor 3 (TRAF3) Ubiquitination to Reduce Host Type I Interferon Production. JBC, 15 pgs. PMID: 27387501. (link)
- Rasouli, Javad, et al. (2015). Expression of GM-CSF in T Cells Is Increased in Multiple Sclerosis and Suppressed by IFN-β Therapy. Journal of Immunology, 20 pgs. PMID: 25917097. (link)
- Li, Yanfang, et al. (2014). A 20-amino-acid deletion in the neuraminidase stalk and a five-amino-acid deletion in the NS1 protein both contribute to the pathogenicity of H5N1 avian influenza viruses in mallard ducks. PLOS One, 12 pgs. PMID: 24743258. (link)
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- Bolen, Christopher, et al. (2013). Dynamic Expression Profiling of Type I and Type III Interferon-Stimulated Hepatocytes Reveals a Stable Hierarchy of Gene Expression. Hepatology, 11 pgs. PMID: 23929627. (link)
- Salvi, et al. (2013). Dual regulation of osteopontin production by TLR stimulation in dendritic cells. JLB. PMID: 23610145. (link)
- Wang, Bei, et al. (2013). Enterovirus 71 protease 2Apro targets MAVS to inhibit anti-viral type I interferon responses. PLOS Pathogens, 18 pgs. PMID: 23555247. (link)
- Popugaeva, Elena, et al. (2012). Dobrava-Belgrade hantavirus from Germany shows receptor usage and innate immunity induction consistent with the pathogenicity of the virus in humans. PLOS One, 10 pgs. PMID: 22545121. (link)
- Witte, et al. (2009). Despite IFN-lambda receptor expression, blood immune cells, but not keratinocytes or melanocytes, have an impaired response to type III interferons: implications for therapeutic applications of these cytokines. Nature, 13 pgs. PMID: 19798076. (link)