Human IFN Beta 1a, mammalian, carrier-free

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Product Features: 
  • Human IFN Beta 1a, mammalian, recombinant protein expressed in CHO cells
  • Supplied without a carrier protein and as a liquid to maintain higher specific activity
  • Used for MS research studies

Ordering

Catalog No. Pack Size Price Quantity
11410-2

1 x 106 units

 $570.00

Specifications

Formulation Supplied as a liquid without a carrier protein
Molecular Weight ~ 23 kDa
Source cDNA obtained from human fibroblast interferon beta 1a mRNA expressed in CHO cells
Purity > 95% by SDS-PAGE stained by Coomassie Blue
Endotoxin level < 1 EU/μg
Bioactivity Measured using a cytopathic inhibition assay on human lung carcinoma cell line A549 with encephalomyocarditis virus (EMCV). EC50 for IFN beta 1a in this assay is ~1 U/ml
Storage For retention of full activity store at 2-8°C. Further dilution of this product for long term storage is not recommended.
Synonyms Human IFNB, Human Beta Interferon, Human IFN Beta 1a, Human Interferon beta 1a, Human Type I Interferon Beta, Human IFN B
Accession Number V00534 

Citations

20 Citations:

  1. Beug, et al. (2019). The transcription factor SP3 drives TNF-α expression in response to Smac mimetics. Science Signaling, 16 pgs. PMID: 30696705. (link)

  2. Viswanathan, Kasinath, et al. (2017). Quantitative Membrane Proteomics Reveals a Role for Tetraspanin Enriched Microdomains During Entry of Human Cytomegalovirus. PLOS One, 27 pgs. PMID: 29121670. (link)

  3. Rahman, Masmudur, et al. (2017). Myxoma Virus dsRNA Binding Protein M029 Inhibits the Type I IFN-Induced Antiviral State in a Highly Species-Specific Fashion. Viruses, 22 pgs. PMID: 28157174. (link)

  4. Bowen, James, et al. (2017). Zika Virus Antagonizes Type I Interferon Responses During Infection of Human Dendritic Cells. PLOS Pathogens, 30 pgs. PMID: 28152048. (link)

  5. Iyer, Shilpa, et al. (2017). Resistance to Type I Interferons is a Major Determinant of HIV-1 Transmission Fitness. PNAS, 10 pgs. PMID: 28069935. (link)

  6. Schwarz, Toni, et al. (2016). VP24-Karyopherin Alpha Binding Affinities Differ Between Ebolavirus Species Influencing Interferon Inhibition and VP24 Stability. JVI, 44 pgs. PMID: 27974555. (link)

  7. Kativhu, Chido, et al. (2016). A Model to Explain How the Bacille Calmette Guerin (BCG) Vaccine Drives Interleukin-12 Production in Neonates. PLOS One, 12 pgs. PMID: 27571272. (link)

  8. Gao, Xioafei, et al. (2016). Citrobacter rodentium NleB Inhibits Tumor Necrosis Factor (TNF) Receptor-Associated Factor 3 (TRAF3) Ubiquitination to Reduce Host Type I Interferon Production. JBC, 15 pgs. PMID: 27387501. (link)

  9. Rasouli, Javad, et al. (2015). Expression of GM-CSF in T Cells Is Increased in Multiple Sclerosis and Suppressed by IFN-β Therapy. Journal of Immunology, 10 pgs. PMID: 25917097. (link)

  10. Li, Yanfang, et al. (2014). A 20-amino-acid deletion in the neuraminidase stalk and a five-amino-acid deletion in the NS1 protein both contribute to the pathogenicity of H5N1 avian influenza viruses in mallard ducks. PLOS One, 12 pgs. PMID: 24743258. (link)

  11. Mostafa, Heba, et al. (2013). Herpes Simplex Virus 1 ICP22 but Not U_S_1.5 is Required for Efficient Acute Replication in Mice and VICE Domain Formation. JVI, 10 pgs. PMID: 24089574. (link)

  12. Salvi, et al. (2013). Dual regulation of osteopontin production by TLR stimulation in dendritic cells. JLB. PMID: 23610145. (link)

  13. Wang, Bei, et al. (2013). Enterovirus 71 protease 2Apro targets MAVS to inhibit anti-viral type I interferon responses. PLOS Pathogens, 18 pgs. PMID: 23555247. (link)

  14. Patel, Dhara, et al. (2012). High Throughout Screening for Small Molecule Enhancers of the Interferon Signaling Pathway to Drive Next-Generation Antiviral Drug Discovery. PLOS One, 12 pgs. PMID: 22574190. (link)

  15. Popugaeva, Elena, et al. (2012). Dobrava-Belgrade hantavirus from Germany shows receptor usage and innate immunity induction consistent with the pathogenicity of the virus in humans. PLOS One, 10 pgs. PMID: 22545121. (link)

  16. Witte, et al. (2009). Despite IFN-lambda receptor expression, blood immune cells, but not keratinocytes or melanocytes, have an impaired response to type III interferons: implications for therapeutic applications of these cytokines. Nature, 13 pgs. PMID: 19798076. (link)

  17. Aguilar, Patricia, et al. (2008). A Five-Amino-Acid Deletion of the Eastern Equine Encephalitis Virus Capsid Protein Attenuates Replication in Mammalian Systems but Not in Mosquito Cells. JVI, 12 pgs. PMID: 18480443. (link)

  18. Reid, Patrick, et al. (2007). Ebola Virus VP24 Proteins Inhibit the Interaction of NPI-1 Subfamily Karyopherin α Proteins with Activated STAT1. JVI, 9 pgs. PMID: 17928350. (link)

  19. Suzuki, Michitaka, et al. (2007). Endosomal accumulation of Toll-like receptor 4 causes constitutive secretion of cytokines and activation of signal transducers and activators of transcription in Niemann-Pick disease type C (NPC) fibroblasts: a potential basis for glial cell activation in the NPC brain. Journal of Neuroscience, 13 pgs. PMID: 17314284. (link)

  20. LaFleur, David, et al. (2001). Interferon-kappa, a Novel Type I Interferon Expressed in Human Keratinocytes. JBC, 7 pgs. PMID: 11514542. (link)

Documentation

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