Quick Search
PBL’s improved site search function is defaulted to an exact match.
Search Term Results |
|
IFN beta |
All interferon beta products and related technical information (e.g. technical notes) |
Human IFN beta |
All human interferon products related technical information (e.g. technical notes) |
IL-2 |
All products contain the term “IL-2”, including IL-23 |
IL 2 |
All products contain the term “IL 2”, including IL-23 |
Erythropoietin |
All EPO products and technical information |
Eryth |
All EPO products and technical information |
The results are displayed in best match products grouped in the following product category filters:
Each filter contains sub-categories for further narrowing of your search results
Other web content such as technical notes that contain the Search Term can be displayed by checking the box next to the corresponding filter on the left side of the Search Results Page.
Catalog No. | Pack Size | Price | Quantity |
---|---|---|---|
51100-7 |
2.5 ml/vial |
$1,245.00 |
Formulation | Supplied frozen diluted in RPMI 1640 with 20% heat inactivated fetal bovine serum (FBS), 10% glycerol and 2.5% dimethyl sulfoxide (DMSO) |
Antigen | Type 1 Interferon (Type I IFN) |
Source | Engineered cells |
Storage | After receipt, store the product at -80 ºC (do not store at any other temperature). Thawed cells should be used within 30 minutes. |
Synonyms | Type I IFN, Type 1 IFN, Type I Interferon, Type 1 Interferon, Human, IFN-alpha, IFN-beta, IFNa, IFNb, Interferon alpha, Interferon beta, iLite |
Application Notes:
Suggested Applications*:
*Please note that these applications are presented for suggested use only and have not been fully evaluated by PBL
The iLite Human Type I Interferon Responsive Cells are engineered cells optimized to express Firefly Luciferase under the control of an IFN a/b responsive promoter. IFNa or IFNb bind to the IFN a/b receptor on the cell surface and activate the IFN a/b regulated Firefly Luciferase reporter gene construct.
iLite Type I IFN Assay Ready Cells are growth arrested cells which are sensitive to human Type I Interferon. The cells can be used in a number of different assays for measuring the bioactivity of Type I Interferon or NAbs to IFN beta or NAbs to IFN alpha.
Interferon alpha (IFNa) has been widely used to treat chronic viral hepatitis and a wide variety of malignant diseases, including hairy cell leukemia, basal cell carcinoma, chronic myeloid leukemia, and cutaneous T-cell lymphoma. Several different recombinant preparations of IFNa are available commercially; the most commonly used formulations include IFNa2a and IFNa2b. A number of studies have shown that development of anti-IFNa neutralizing antibodies (NAbs) is correlated with a loss of IFNa treatment efficacy.
Interferon beta (IFNb) is well established as first line therapy in relapsing/remitting multiple sclerosis. The occurrence of NAbs and binding antibodies (BAbs) to IFNb has been widely reported. Subjects with NAbs have shown reduced response to treatment with IFNb, having higher relapse rates, increased MRI activity and higher risk of disease progression. The frequencies and titers of NAbs vary depending on the preparation used, dose and frequency of administration and also the assay used to quantify them.
4 Citations:
Find your lot-specific Certificate of Analysis here!
Finding the right biomarker detection service to meet your project needs just got easier...
Sign up for our email list to be kept up-to-date on the latest product releases and company news!
PBL Assay Science offers scientists a comprehensive range of assay kits, interferons, cytokines, growth factors and antibodies. Our high quality products provide consistent, reliable performance and are suitable for use in a range of research applications.
Quick Search
PBL’s improved site search function is defaulted to an exact match.
Search Term Results |
|
IFN beta |
All interferon beta products and related technical information (e.g. technical notes) |
Human IFN beta |
All human interferon products related technical information (e.g. technical notes) |
IL-2 |
All products contain the term “IL-2”, including IL-23 |
IL 2 |
All products contain the term “IL 2”, including IL-23 |
Erythropoietin |
All EPO products and technical information |
Eryth |
All EPO products and technical information |
The results are displayed in best match products grouped in the following product category filters:
Each filter contains sub-categories for further narrowing of your search results
Other web content such as technical notes that contain the Search Term can be displayed by checking the box next to the corresponding filter on the left side of the Search Results Page.