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Full Product Name: Human Interleukin-29 (IL-29)/Interferon Lambda 1, carrier-free
Catalog No. | Pack Size | Price | Quantity |
---|---|---|---|
11826-1 |
25 μg |
$510.00 |
Formulation | Supplied lyophilized without a carrier protein |
Molecular Weight | Based on N-terminal sequencing, the mature recombinant IL-29 starts at Gly 20 and has a calculated molecular mass of 21.4 kDa. As a result of glycosylation, the recombinant monomer migrates as an approximately 26-35 kDa protein in SDS-PAGE under reducing conditions. |
Source | DNA sequence encoding the signal peptide from human CD33 was fused to the carboxyl terminally polyhistidine-tagged mature human IL-29 (Gly 20-Thr 200). The chimeric protein was expressed in a mouse myeloma cell line, NS0. |
Purity | Greater than 95% Endotoxin level < 1 EU/μg |
Bioactivity | Human HepG2 cells infected with encephalomyocarditis virus, ED50 1-5 ng/ml |
Storage | For retention of full activity store at -70°C or below and avoid repeated freeze/thaw cycles |
Synonyms | Hu IL-29; Hu IFN-λ1 |
Accession Number | Q8IU54 |
The IFN lambda gene family is composed of three distinct genes: IFN lambda 1 (IL-29), IFN lambda 2 (IL-28A) and IFN lambda 3 (IL-28B). All three are class II cytokine receptor ligands that are distinctly related to members of the IL-10 family and Type I family. Refer to the product specific datasheet for references associated with this information.
IL-28A, IL-28B, and IL-29, also named interferon-λ2 (IFN-λ2), IFN-λ3, and IFN-λ1, respectively, are newly identified class II cytokine receptor ligands that are distantly related to members of the IL-10 family (11-13% aa sequence identity) and type I IFN family (15 - 19% aa sequence identity).1 – 3 The genes encoding these three cytokines are localized to chromosome 19 and each is composed of multiple exons. The exon organization of these genes is also found in the IL-10 family genes but is distinct from the type I IFNs, which are encoded within a single exon. The expression of IL-28A, B, and IL-29 is induced by virus infection or double-stranded RNA. All three cytokines exert bioactivities that overlap those of type I IFNs, including antiviral activity and up-regulation of MHC class I antigen expression. The three proteins signal through the same heterodimeric receptor complex that is composed of the IL-10 receptor β (IL-10 Rβ) and a novel IL-28 receptor α (IL-28 Rα, also known as IFN-λ R1). Ligand binding to the receptor complex induces Jak kinase activation and STAT1 and STAT2 tyrosine phosphorylation. The phosphorylated STAT1 and STAT2 complex with IFN-regulatory factor 9 (IRF-9) to form the IFN-stimulated regulatory factor 3 (ISGF-3) transcription factor complex that is translocated to the nucleus. ISGF-3 binds to the IFN-stimulated response element (ISRE) present in the regulatory regions of the target genes. Human IL-29 cDNA encodes a 200 amino acid (aa) residue precursor protein with a putative 19 aa signal peptide and a 181 aa mature protein, which is a monomer in solution. It shares 67% and 69% aa sequence identity with human IL-28A and human IL-28B, respectively.
References:
Catalog No. | Description | Pack Size | Price | Quantity |
---|---|---|---|---|
11720-1 |
Human IL-28A/IFN Lambda 2, HCE |
≥ 1 x 105 units |
$285.00 |
|
11725-1 |
Human IL-29/IFN Lambda 1, HCE |
≥ 1 x 105 units |
$285.00 |
|
11821-1 |
Human Interleukin-28A/Interferon Lambda 2, carrier-free |
25 μg |
$510.00 |
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PBL Assay Science offers scientists a comprehensive range of assay kits, interferons, cytokines, growth factors and antibodies. Our high quality products provide consistent, reliable performance and are suitable for use in a range of research applications.
Quick Search
PBL’s improved site search function is defaulted to an exact match.
Search Term Results |
|
IFN beta |
All interferon beta products and related technical information (e.g. technical notes) |
Human IFN beta |
All human interferon products related technical information (e.g. technical notes) |
IL-2 |
All products contain the term “IL-2”, including IL-23 |
IL 2 |
All products contain the term “IL 2”, including IL-23 |
Erythropoietin |
All EPO products and technical information |
Eryth |
All EPO products and technical information |
The results are displayed in best match products grouped in the following product category filters:
Each filter contains sub-categories for further narrowing of your search results
Other web content such as technical notes that contain the Search Term can be displayed by checking the box next to the corresponding filter on the left side of the Search Results Page.