Mouse IFN Beta, mammalian

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Product Features: 
  • Authentic sequence of Mouse IFN Beta protein with no tag
  • 10 fold greater specific activity than E.coli derived protein
  • Glycosylated

Ordering

Catalog No. Pack Size Price Quantity
12405-1

1 x 105 units

 $270.00

Specifications

Formulation Supplied frozen in 20mM Sodium Phosphate pH 6.4; 300mM NaCl; 5% Glycerol; 0.1% Bovine Serum Albumin (BSA)
Molecular Weight 19.6 kDa
Source Gene obtained from mouse DNA expressed in mammalian cells
Purity > 95% by SDS-PAGE stained by Coomassie Blue
Endotoxin level < 1 EU/μg
Bioactivity Measured using a cytopathic effect inhibition assay on Mouse (L929) cells with EMCV
EC50 for IFN Beta is ~ 2.5 U/ml
Storage For retention of full activity store at -70°C or below and avoid repeated freeze/thaw cycles
Synonyms Mouse Beta Interferon, Mouse IFN Beta, Mouse IFNB, Mouse Type I IFN beta, Mouse Fibroblast IFN, Mouse Fibroblast Interferon, Mouse Beta IFN, Mouse Type I Interferon Beta
Accession Number K00020

Tech Info / Data

Background: 

Interferons (IFNs) are a family of mammalian cytokines produced by macrophages, neutrophils, dendritic cells and other somatic cells in response to viruses and pathogens. IFN Beta is classified as a type I IFN and is produced by fibroblast and a variety of cell types in response to viral challenge. Although all type I IFNs bind to the same type I IFN receptor complex, studies have shown that IFN Beta signals differently than IFN Alpha. Furthermore, it has been shown that IFN Beta exerts preferential induction of apoptotic effect on melanoma cells. These findings, along with the therapeutic use of IFN Beta in Multiple Sclerosis and hepatitis C, make further understanding of IFN Beta biological activities an important area of research. 

The mammalian expressed mouse IFN Beta protein is designed to provide scientists with a highly active recombinant protein that closely resembles native mouse IFN Beta.

Citations

6 Citations:

  1. Alphonse, N. et al.,  (2022), "A family of conserved bacterial virulence factors dampens interferon responses by blocking calcium signaling", Cell, S0092-8674(22)00526-8, PMID: 35568036, DOI: 10.1016/j.cell.2022.04.028 (link)
  2. Tang, Z. et al., (2021), "Inflammatory macrophages exploit unconventional pro-phagocytic integrins for phagocytosis and anti-tumor immunity", Cell Reports, 37:110111, DOI: 10.1016/j.celrep.2021.110111. (link)
  3. Zhang et al., (2020), Type I interferon signaling mediates Mycobacterium tuberculosis-induced macrophage death, JEM 218(2), PMID: 33125053 (link)

  4. Mine, Keiichiro, et al. (2019). Impaired upregulation of Stat2 gene restrictive to pancreatic β-cells is responsible for virus-induced diabetes in DBA/2 mice. Biochemical and Biophysical Research Communications, 8 pgs. PMID: 31708097. (link)

  5. Wang, Kuan-Chung (2018). Dichotomy of TNF Family Ligands Expression on Classical Dendritic Cells and Monocyte-Derived Antigen Presenting Cells During Viral Infection. University of Toronto, 92 pgs. PMID: no PMID. (link)

  6. Masroori, Nasser, et al. (2016). The Interferon-Induced Arrival Protein PML (TRIM19) Promotes the Restriction and Transcriptional Silencing of Lentiviruses in a Context-Specific, Isoform-Specific Fashion. Retrovirology, 17 pgs. PMID: 27000403. (link)

Documentation

Mammalian expressed (12405) vs. E.coli expressed (12400) mouse IFN-Beta as measured in L929/EMCV CPE activity assay

12405-1 Mouse IFN Beta, mammalian

Results are representative and may vary depending upon experimental conditions

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