Background

IFN-Beta is generally the first Type I IFN to be expressed after viral infection. In the mouse both IFN-Beta and IFN-Alpha 4 prime cells for the production of the other Type I IFNs. Mouse IFN-Beta was originally cloned by Higashi et al. [(1983) J. Biol. Chem. 258(15):9522] and has been engineered to contain a disulfide which confers added stability. 

55 Citations

1. Bosnjak, M.,  et al., (2022), "In vitro and in vivo corrrelation of skin and cellular responses to nucleic acid delivery", Biomedicine & Pharmacotherapy, 150, DOI: 10.1016/j.biopha.2022.113088 (link)


2. Zhu, J. et al., (2022), "LincRNA-EPS impairs host antiviral immunity by antagonizing viral RNA-PKR interaction", EMBO Reports, e53937, PMID: 35312340, DOI: 0.15252/embr.202153937 (link)


3. Panagioti, E., et al., (2021), Immunostimulatory bacterical antigen-armed oncolytic measles virotherapy significantly increases the potency of anti-PD1 checkpoint therapy, J.Clin. Invest., 131(10):e141614, DOI: 10.1172/JCI141614 (link)


4. Ma, Hongming, et al. (2020). Barrier-to-Autointegration Factor 1 Protects Against a Basal cGAS-STING Response. mBio, 15 pgs. PMID: 32156810. (link)


5. Platanitis, et al. (2019). A molecular switch from STAT2-IRF9 to ISGF3 underlies interferon-induced gene transcription. Nature Communications, 17 pgs. PMID: 31266943. (link)


6. Neil, Jessica, et al. (2019). IFN-I and IL-22 mediate protective effects of intestinal viral infection. Nature Microbiology, 16 pgs. PMID: 31182797. (link)


7. Markosyan, Nune, et al. (2019). Tumor cell-intrinsic EPHA2 suppresses anti-tumor immunity by regulating PTGS2 (COX-2). JCI, 40 pgs. PMID: 31162144. (link)


8. Wang, Andrew, et al. (2019). Specific sequences of infectious challenge lead to secondary hemophagocytic lymphohistiocytosis-like disease in mice. PNAS. PMID: 30674681. (link)


9. Marro, Brett, et al. (2019). Macrophage IFN-I signaling promotes autoreactive T cell infiltration into islets in type 1 diabetes model. JCI Insight, 13 pgs. PMID: 30674713. (link)


10. Chen, et al. (2019). Sephin1, which prolongs the integrated stress response, is a promising therapeutic for multiple sclerosis. Brain, 18 pgs. PMID: 30657878. (link)


11. Michalicka, Matthew (2019). COMBINATION IMMUNOTHERAPY WITH INHIBITOR OF APOPTOSIS (IAP) ANTAGONISTS TO TREAT NEUROBLASTOMA. University of Ottawa, 153 pgs. PMID: no PMID.


12. Li, et al. (2018). The Cyclopeptide Astin C Specifically Inhibits the Innate Immune CDN Sensor STING. CellPress. PMID: 30566866. (link)


13. Sharma, Deepika, et al. (2018). TNF/TNFR Axis Promotes Pyrin Inflammasome Activation and Distinctly Modulates Pyrin Inflammasomopathy. JCI , 14 pgs. PMID: 30457980. (link)


14. Takahashi, Akiko, et al. (2018). Downregulation of Cytoplasmic DNases is Implicated in Cytoplasmic DNA Accumulation and SASP in Senescent Cells. Nature Communications, 12 pgs. PMID: 29593264.  (link)


15. Cui, Huachun, et al. (2018). IFN Regulatory Factor 2 Inhibits Expression of Glycolytic Genes and Lipopolysaccharide-Induced Proinflammatory Responses in Macrophage. Journal of Immunology, 27 pgs. PMID: 29563175. (link)


16. Kim, Kyoung Min, et al. (2018). Interferon beta Protects Against Avascular Osteonecrosis Through Interleukin 6 Inhibition and Silent Information Regulator Transcript-1 Upregulation. Oncotarget, 14 pgs. PMID: 29423066. (link)


17. Elias, Salah, et al. (2018). Blimp-1/PRDM1 is a Critical Regulator of Type III Interferon Responses in Mammary Epithelial Cells. Scientific Reports, 11 pgs. PMID: 29321612. (link)


18. Zhu, Qifan (2018). Roles of Cytosolic Nucleic Acid Sensors in Cancer and Infection. UTHSC, 107 pgs. PMID: no PMID.


19. Case, James (2018). Roles of the Coronavirus 3'-to-5' Exoribonuclease and N7-Methyltransferase in Counteracting Innate Immunity. Vanderbilt University, 211 pgs. PMID: no PMID. (link)


20. McDonough, Ashley, et al. (2017). Ischemia/Reperfusion Induces Interferon-Stimulated Gene Expression in Microglia. Journal of Neuroscience, 17 pgs. PMID: 28747383. (link)


21. Nakaya, Yuki, et al. (2017). AIM2-Like Receptors Positively and Negatively Regulate the Interferon Response Induced by Cytosolic DNA. mBio, 17 pgs. PMID: 28679751. (link)


22. Stier, Matthew T, et al. (2017). STAT1 Represses Cytokine-Producing Group 2 and Group 3 Innate Lymphoid Cells during Viral Infection. Journal of Immunology, 25 pgs. PMID: 28576981. (link)


23. Beug, Shawn, et al. (2017). Smac Mimetics Synergize with Immune Checkpoint Inhibitors to Promote Tumour Immunity Against Glioblastoma. Nature Communications, 15 pgs. PMID: 28198370. (link)


24. Rahman, Masmudur, et al. (2017). Myxoma Virus dsRNA Binding Protein M029 Inhibits the Type I IFN-Induced Antiviral State in a Highly Species-Specific Fashion. Viruses, 22 pgs. PMID: 28157174. (link)


25. Labzin, Larisa I, et al. (2015). ATF3 Is a Key Regulator of Macrophage IFN Responses. Journal of Immunology, 11 pgs. PMID: 26416280. (link)


26. Onabajo, Olusegun, et al. (2015). Expression of Interferon Lambda 4 is Associated with Reduced Proliferation and Increased Cell Death in Human Hepatic Cells. Journal of Interferon & Cytokine Research, 13 pgs. PMID: 26134097. (link)


27. Majumdar, Tanmay, et al. (2015). Induction of interferon-stimulated genes by IRF3 promotes replication of Toxoplasma gondii. PLOS Pathogens, 22 pgs. PMID: 25811886. (link)


28. Foxman, Ellen, et al. (2015). Temperature-Dependent Innate Defense Against the Common Cold Virus Limits Viral Replication at Warm Temperature in Mouse Airway Cells. PNAS, 6 pgs. PMID: 25561542. (link)


29. Welsby, Iain, et al. (2014). PARP12, an interferon-stimulated gene involved in the control of protein translation and inflammation. JBC, 17 pgs. PMID: 25086041. (link)


30. Duong, Sean, et al. (2014). Polymicrobial sepsis alters antigen-dependent and -independent memory CD8 T cell functions. Journal of Immunology, 20 pgs. PMID: 24646738. (link)


31. Lu, Ben, et al. (2014). JAK/STAT1 signaling promotes HMGB1 hyperacetylation and nuclear translocation. PNAS, 6 pgs. PMID: 24469805. (link)


32. Taylor, Juliet, et al. (2014). Type I Interferon Signaling Mediates Neuro-Inflammatory Events in Model of Alzheimer's Disease. Neurobiology of Aging, 12 pgs. PMID: 24262201. (link)


33. Low-Calle, Ana Maria, et al. (2014). Characterization of a Murine Neuron-Enriched Model of Primary Trigeminal Ganglia Cultures to Study the Interferon-beta Antiviral Effect Against Herpes Simplex Virus Type 1. Infectio, 8 pgs. PMID: no PMID. (link)


34. Munitic, Ivana, et al. (2013). Optineurin insufficiency impairs IRF3 but not NF-κB activation in immune cells. Journal of Immunology, 23 pgs. PMID: 24244017. (link)


35. Li, et al. (2013). A Short Hairpin RNA Screen of Interferon-Stimulated Genes Identifies a Novel Negative Regulator of the Cellular Antiviral Response. mBio, 11 pgs. PMID: 23781071. (link)


36. Gandhapudi, et al. (2013). TRIF is Required for TLR4 Mediated Adjuvant Effects on T Cell Clonal Expression. PLOS One, 11 pgs. PMID: 23457630. (link)


37. Chen, Xuefen, et al. (2012). Requirement for the Histone Deacetylase Hdac3 for the Inflammatory Gene Expression Program in Macrophages. PNAS, 10 pgs. PMID: 22802645. (link)


38. Freeman, Bailey E, et al. (2012). Regulation of innate CD8+ T-cell activation mediated by cytokines. PNAS, 6 pgs. PMID: 22665806. (link)


39. Sutherland, et al. (2011). Evaluating vaccinia virus cytokine co-expression in TLR GKO mice. Immunology and Cell Biology. PMID: 21173782. (link)


40. Leu, Shaw-Wei, et al. (2011). TLR4 through IFN-β promotes low molecular mass hyaluronan-induced neutrophil apoptosis. Journal of Immunology, 8 pgs. PMID: 21098223. (link)


41. Li, et al. (2010). IFN-alpha Expression and Antiviral Effects are Subtype and Cell Type Specific in the Cardiac Response to Viral Infection. JVI, 22 pgs. PMID: 19896686. (link)


42. Chang, Tsung-Hsien, et al. (2009). Ebola Zaire Virus Blocks Type I Interferon Production by Exploiting the Host SUMO Modification Machinery. PLOS Pathogens, 15 pgs. PMID: 19557165. (link)


43. Trilling, Mirko, et al. (2009). Gamma Interferon-Induced Interferon Regulatory Factor 1-Dependent Antiviral Response Inhibits Vaccinia Virus Replication in Mouse but Not Human Fibroblasts. JVI, 36 pgs. PMID: 19211768. (link)


44. Yamada, Atsushi, et al. (2009). IFN-gamma down-regulates Secretoglobin 3A1 gene expression. National Institute of Health, 9 pgs. PMID: 19135978. (link)


45. Richez, Christophe, et al. (2009). TLR4 Ligands Induce IFN-alpha Production by Mouse Conventional Dendritic Cells and Human Monocytes after IFN-beta Priming. Journal of Immunology, 10 pgs. PMID: 19124725. (link)


46. Capraro, et al. (2008). Virus Growth and Antibody Responses Following Respiratory Tract Infection of Ferrets and Mice with WT and P/V Mutants of the Paramyxovirus Simian Virus 5. JVI, 26 pgs. PMID: 18456301. (link)


47. Guo, Beichu, et al. (2008). The type I IFN induction pathway constrains Th17-mediated autoimmune inflammation in mice. JCI, 11 pgs. PMID: 18382764. (link)


48. Molle, Celine, et al. (2007). IL-27 synthesis induced by TLR ligation critically depends on IFN regulatory factor 3. Journal of Immunology, 10 pgs. PMID: 17548596. (link)


49. O'Connell, Ryan, et al. (2007). MicroRNA-155 is induced during the macrophage inflammatory response. PNAS, 6 pgs. PMID: 17242365. (link)


50. Zhou, Haixia, et al. (2007). Mouse Hepatitis Virus Does Not Induce Beta Interferon Synthesis and Does Not Inhibit Its Induction by Double-Stranded RNA. JVI, 7 pgs. PMID: 17079305. (link)


51. Kamphuis, Elisabeth, et al. (2006). Type I interferons directly regulate lymphocyte recirculation and cause transient blood lymphopenia. Blood Journal, 10 pgs. PMID: 16868248. (link)


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