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Rhesus/Cynomolgus IFN-Alpha 2

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Rhesus/Cynomolgus IFN-Alpha 2

Catalog Number: 14110

Recombinant Rhesus/Cynomolgus Interferon Alpha 2 expressed in E.coli


Pack Size
Product Info

Bioactivity Measured using cytopathic effect inhibition assays on Bovine (MDBK) cells with VSV and Human (A549) cells with EMCV
The EC50 for bovine IFN is ~ 5 U/ml
The EC50 for human IFN is ~ 1 U/ml.


Formulation Supplied frozen with a carrier protein
Molecular Weight 19.5 kDa
Source cDNA expressed in E.coli
Purity > 98% by SDS-PAGE stained by Coomassie Blue
Endotoxin level < 1 EU/μg
Storage For retention of full activity store at -70°C or below and avoid repeated freeze/thaw cycles
Accession Number XM_001107516

Tech Info & Data



The cDNA for Rheus/Cynomolgus IFN-Alpha 2 was cloned from the Rhesus cell line LLC-MK2. This was found to be identical to the putative Rhesus IFN-Alpha 2 (XM_001107516) identified as part of the Rhesus genome project. There are 14 AA differences in the mature protein (2 in the signal peptide) between the Rhesus and Human Alpha A (2a) sequence. There are 13 AA differences in the mature protein (2 in the signal peptide) between the Rhesus and Human Alpha 2 (2b) sequence. This is in accord with a previous report [Villinger et al. (1995) J. Immunol. 155:3946] stating that there are 15-16 amino acids different between the Rhesus IFN-Alpha 2 and human alpha 2 (2b) and human alpha A(2a) respectively.


This Rhesus (Macaca mulatta) sequence is also identical to a Cynomolgus (Macaca fascicularis) IFN-Alpha 2 cloned from cDNA isolated from primary hepatocytes (PBL unpublished observation).


3 Citations


  1. Mudd, Joseph, et al. (2018). Hallmarks of Primate Lentiviral Immunodeficiency Infection Recapitulate Loss of Innate Lymphoid Cells. Nature Communications, 12 pgs. PMID: 30262807. (link)

  2. Wonderlich, Elizabeth, et al. (2015). Macrophages and Myeloid Dendritic Cells Lose T Cell-Stimulating Function in Simian Immunodeficiency Virus Infection Associated with Diminished IL-12 and IFN-alpha Production. Journal of Immunology, 9 pgs. PMID: 26297760. (link)

  3. Dudek, Arkadiusz, et al. (2007). First in Human Phase I Trial of 852A, a Novel Systemic Toll-like Receptor 7 Agonist, to Activate Innate Immune Responses in Patients with Advanced Cancer. Clinical Cancer Research, 8 pgs. PMID: 18056192. (link)



  1. Villinger et al. (1995) J. Immunol. 155:3946.


Certificate of Analysis (CoA) and Safety Data Sheet (SDS)
14110-1 CoA

14110-1 Certificate of Analysis (CoA)

14110 SDS

14110 Safety Data Sheet