Mouse IFN Alpha 11
Specifications
| Formulation | Supplied frozen in phosphate-buffered saline (PBS) containing 0.1% Bovine Serum Albumin (BSA) |
| Molecular Weight | 19.1 kDa |
| Source | cDNA obtained from mouse leukocyte interferon expressed in E.coli |
| Purity | > 95% by SDS-PAGE stained by Coomassie Blue Endotoxin level < 1 EU/μg |
| Bioactivity | Measured using a cytopathic inhibition assay on Mouse (L929) cells with EMCV. The EC50 for IFN in this assay is ~ 5 U/ml. |
| Storage | For retention of full activity store at -70°C or below and avoid repeated freeze/thaw cycles |
| Synonyms | Mu IFN-α11, Mouse IFN Alpha Subtype, Mouse IFN Protein Subtype, Interferon Alpha, IFN Alpha, IFN-a, Type I IFN Alpha |
| Accession Number | AY225954 |
Tech Info / Data
Mouse IFN Alpha 11 was originally identified as an interferon whose expression was not upregulated by viral infection of cells [Coulombel et al. (1991) Gene 104(2):187]
Expression of Mouse IFN Alpha 11 is induced by poly(I):poly(C) and some virus, but not others in L929 cells [Fung et al. (2004) J. Imm. Meth. 284:177]. It has been suggested that expression of this IFN may be regulated by OCT-1 and Ptx-1 [Mesplede et al. (2005) Mol. Cell Biol. 25(19):8717, Lopez et al. Mol. Cell Biol. 10(20):7527]. Additionally, a number of studies have suggested that the expression of this IFN is tightly regulated [reviewed by Doly et al. (1998) Cell. Mol. Life Sci. 54:1109].
Summary: Mouse IFN Alpha 11 is a high activity interferon whose expression has been extensively studied and is tightly regulated.
For more information on Mouse IFN Alpha subtype nomenclature click here.
Citations
Documentation
Comparison of Mouse IFN Alpha 11 and Mouse IFN Alpha A Antiviral Activity
The activity of Mouse IFN Alpha 11 and Mouse IFN Alpha A was compared. The EC50 for Mouse IFN Alpha 11 was 7 pg/ml.
Results are representative and may vary depending upon experimental conditions.
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