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Mouse IFN-Alpha 11

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Mouse IFN-Alpha 11

Catalog Number: 12125

Recombinant Mouse Interferon Alpha 11 protein expressed in E.coli.

$365.00

Pack Size
Product Info

Mouse IFN-Alpha 11 is a high-activity interferon whose expression has been extensively studied and is tightly regulated.

 

IFN-Alpha 4 is a member of the mouse type I IFN family that has high specific activity relative to other mouse IFN-Alpha subtypes.

Specifications

FormulationSupplied frozen in phosphate-buffered saline (PBS) containing 0.1% Bovine Serum Albumin (BSA)
Molecular Weight19.1 kDa
SourcecDNA obtained from mouse leukocyte interferon expressed in E.coli
Purity> 95% by SDS-PAGE stained by Coomassie Blue
Endotoxin level < 1 EU/μg
BioactivityMeasured using a cytopathic inhibition assay on Mouse (L929) cells with EMCV.
The EC50 for IFN in this assay is ~ 5 U/ml.
StorageFor retention of full activity store at -70°C or below and avoid repeated freeze/thaw cycles
SynonymsMu IFN-α11, Mouse IFN Alpha Subtype, Mouse IFN Protein Subtype, Interferon Alpha, IFN Alpha, IFN-a, Type I IFN Alpha
Accession NumberAY225954

Tech Info & Data

Background

 

Mouse IFN-Alpha 11 was originally identified as an interferon whose expression was not upregulated by viral infection of cells [Coulombel et al. (1991) Gene 104(2):187]

 

Expression of Mouse IFN-Alpha 11 is induced by poly(I):poly(C) and some virus, but not others in L929 cells [Fung et al. (2004) J. Imm. Meth. 284:177]. It has been suggested that expression of this IFN may be regulated by OCT-1 and Ptx-1 [Mesplede et al. (2005) Mol. Cell Biol. 25(19):8717, Lopez et al. Mol. Cell Biol. 10(20):7527]. Additionally, a number of studies have suggested that the expression of this IFN is tightly regulated [reviewed by Doly et al. (1998) Cell. Mol. Life Sci. 54:1109].

 

Summary: Mouse IFN-Alpha 11 is a high-activity interferon whose expression has been extensively studied and is tightly regulated.

 

For more information on Mouse IFN-Alpha subtype nomenclature click here.

Citations

2 Citations

 

  1. Sang, Allison, et al. (2018). Innate and Adaptive Signals Enhance Differentiation and Expansion of Dual-Antibody Autoreactive B Cells in Lupus. Nature Communications, 14 pgs. PMID: 30266981. (link)
  2. Swanson, Cristina, et al. (2010). Type I IFN enhances follicular B cell contribution to the T cell–independent antibody response. JEM, 16 pgs. PMID: 20566717. (link)

 

References

 

  1. Coulombel et al. (1991) Gene 104(2):187.
  2. Fung et al. (2004) J. Imm. Meth. 284:177.
  3. Mesplede et al. (2005) Mol. Cell. Biol. 25 (19):8711.
  4. Lopez et al. (2000) Mol. Cell. Biol. 10 (20) 7527.
  5. Doly et al. (1998) Cell. Mol. Life Sci. 54:1109.

Documentation

Certificate of Analysis (CoA) and Safety Data Sheet (SDS)
12125-1 CoA

12125-1 Certificate of Analysis (CoA)

12125 SDS

12125 Safety Data Sheet