Mouse IFN Alpha 11

Home / Products / Proteins / Interferons / Mouse IFN Proteins / Mouse IFN Alpha 11
Product Features: 
  • Recombinant Mouse IFN Alpha 11 protein expressed in E.coli
  • Member of the mouse type I IFN family that has high specific activity relative to other mouse IFN alpha subtypes

Ordering

Catalog No. Pack Size Price Quantity
12125-1

1 x 105 units

 $335.00

Specifications

Formulation Supplied frozen in phosphate-buffered saline (PBS) containing 0.1% Bovine Serum Albumin (BSA)
Molecular Weight 19.1 kDa
Source cDNA obtained from mouse leukocyte interferon expressed in E.coli
Purity > 95% by SDS-PAGE stained by Coomassie Blue
Endotoxin level < 1 EU/μg
Bioactivity Measured using a cytopathic inhibition assay on Mouse (L929) cells with EMCV.
The EC50 for IFN in this assay is ~ 5 U/ml.
Storage For retention of full activity store at -70°C or below and avoid repeated freeze/thaw cycles
Synonyms Mu IFN-α11, Mouse IFN Alpha Subtype, Mouse IFN Protein Subtype, Interferon Alpha, IFN Alpha, IFN-a, Type I IFN Alpha
Accession Number AY225954

Tech Info / Data

Background: 

Mouse IFN Alpha 11 was originally identified as an interferon whose expression was not upregulated by viral infection of cells [Coulombel et al. (1991) Gene 104(2):187]

Expression of Mouse IFN Alpha 11 is induced by poly(I):poly(C) and some virus, but not others in L929 cells [Fung et al. (2004) J. Imm. Meth. 284:177]. It has been suggested that expression of this IFN may be regulated by OCT-1 and Ptx-1 [Mesplede et al. (2005) Mol. Cell Biol. 25(19):8717, Lopez et al. Mol. Cell Biol. 10(20):7527]. Additionally, a number of studies have suggested that the expression of this IFN is tightly regulated [reviewed by Doly et al. (1998) Cell. Mol. Life Sci. 54:1109].

Summary: Mouse IFN Alpha 11 is a high activity interferon whose expression has been extensively studied and is tightly regulated.

For more information on Mouse IFN Alpha subtype nomenclature click here.

Citations

2 Citations:

  1. Sang, Allison, et al. (2018). Innate and Adaptive Signals Enhance Differentiation and Expansion of Dual-Antibody Autoreactive B Cells in Lupus. Nature Communications, 14 pgs. PMID: 30266981. (link)

  2. Swanson, Cristina, et al. (2010). Type I IFN enhances follicular B cell contribution to the T cell–independent antibody response. JEM, 16 pgs. PMID: 20566717. (link)

References:

  1. Coulombel et al. (1991) Gene 104(2):187.

  2. Fung et al. (2004) J. Imm. Meth. 284:177.

  3. Mesplede et al. (2005) Mol. Cell. Biol. 25 (19):8711.

  4. Lopez et al. (2000) Mol. Cell. Biol. 10 (20) 7527.

  5. Doly et al. (1998) Cell. Mol. Life Sci. 54:1109.

Documentation

Comparison of Mouse IFN Alpha 11 and Mouse IFN Alpha A Antiviral Activity

12125-1 Mouse IFN Alpha 11

The activity of Mouse IFN Alpha 11 and Mouse IFN Alpha A was compared. The EC50 for Mouse IFN Alpha 11 was 7 pg/ml.

Results are representative and may vary depending upon experimental conditions.

Related Products

Catalog No. Description Pack Size Price Quantity
12100-1 Mouse Interferon Alpha A

1 x 105 units

 $425.00
12115-1 Mouse Interferon Alpha 4, mammalian

1 x 105 units

 $385.00
22100-1 Anti-Mouse Interferon Alpha, Clone RMMA-1 (MAb)

250 μg

 $515.00

Looking for a CoA?

Find your lot-specific Certificate of Analysis here!

Which service best suits your needs?

Finding the right biomarker detection service to meet your project needs just got easier...

Want to stay in touch?

Sign up for our email list to be kept up-to-date on the latest product releases and company news!

Go to top