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IFN beta |
All interferon beta products and related technical information (e.g. technical notes) |
Human IFN beta |
All human interferon products related technical information (e.g. technical notes) |
IL-2 |
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NOTE: There has been a formulation change to the Hu IFN Beta Standard, please see the Product Notice located under the Documentation tab below for more information.
Full Product Name: VeriKine Human Interferon Beta ELISA Kit
Catalog No. | Pack Size | Price | Quantity |
---|---|---|---|
41410-1 |
1 x 96-well plate |
$645.00 |
|
41410-2 |
5 x 96-well plate |
$2,370.00 $2,625.00 |
Materials Provided:
The VeriKine Human Interferon Beta ELISA Kit has been developed to measure levels of human IFN-β in buffers or tissue culture media (TCM) samples by sandwich enzyme linked immunosorbent assay (ELISA). It is developed for superior performance with intra-assay and inter-assay CVs of ≤ 8%. The lowest concentration of Hu-IFN-β that can be detected in a test sample is 50 pg/ml. This kit is not designed to measure Hu-IFN-β in human serum. The kit is based on an ELISA with streptavidin conjugated to horseradish peroxidase (HRP). Tetramethyl-benzidine (TMB) is the substrate. The assay is based on the international reference standard for human interferon beta (Hu-IFN-β) provided by the National Institutes of Health.
Following secretion, Interferon Beta binds to type I interferon receptors on proximal or distal cells activating the JAK1-STAT signaling pathway. Activation of this signal transduction pathway leads to the expression of 2’-5’ oligoadenylate synthetases (2’5’ OAS), protein kinase R (PKR), MxA proteins, and interferon regulatory factor 7 (IRF-7). The upregulation of IRF-7 expression can exert a positive feedback on IFN-β production, whereas the induction of 2’5’ OAS activates a latent endonuclease known as RNase L. RNase L cleaves both viral and cellular single stranded mRNA, thereby limiting viral replication and dissemination.
IFN-beta is present as a single gene in humans. The biological activity of IFN-beta can be functionally similar when compared to other type I IFNs, but can also exhibit distinct gene expression patterns as compared to IFN-alpha. In vitro binding studies suggest that IFN-beta binds to the Type I IFN receptor with higher affinity than the other Type I IFNs and this may regulate receptor internalization in a different manner. IFN-β has long been known to inhibit viral replication as part of the body’s innate antiviral response and it is currently used as a therapeutic for treatment of relapsing-remittent multiple sclerosis and some tumors.
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Assay Range: 50 - 4000 pg/ml
Catalog No. | Description | Pack Size | Price | Quantity |
---|---|---|---|---|
41415-1 |
VeriKine-HS Human Interferon Beta Serum ELISA Kit Compatibility: Serum, Plasma, Tissue Culture Media Assay Range: 1.2-150 pg/ml |
1 x 96-well plate |
$725.00 |
|
41435-1 |
VeriKine-HS Human IFN Beta TCM ELISA Kit new Compatibility: Tissue Culture Media Assay Range: 2.34 - 150 pg/ml |
1 x 96-well plate |
$485.00 |
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PBL Assay Science offers scientists a comprehensive range of assay kits, interferons, cytokines, growth factors and antibodies. Our high quality products provide consistent, reliable performance and are suitable for use in a range of research applications.
Quick Search
PBL’s improved site search function is defaulted to an exact match.
Search Term Results |
|
IFN beta |
All interferon beta products and related technical information (e.g. technical notes) |
Human IFN beta |
All human interferon products related technical information (e.g. technical notes) |
IL-2 |
All products contain the term “IL-2”, including IL-23 |
IL 2 |
All products contain the term “IL 2”, including IL-23 |
Erythropoietin |
All EPO products and technical information |
Eryth |
All EPO products and technical information |
The results are displayed in best match products grouped in the following product category filters:
Each filter contains sub-categories for further narrowing of your search results
Other web content such as technical notes that contain the Search Term can be displayed by checking the box next to the corresponding filter on the left side of the Search Results Page.