Mouse IFN Beta ELISA Kit (TCM, Serum)

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Product Features: 
  • Measures mouse IFN beta in tissue culture media (TCM) and mouse serum

Full Product Name: VeriKine Mouse Interferon Beta ELISA Kit

Ordering

Catalog No. Pack Size Price Quantity
42400-1

1 x 96-well plate

 $710.00
42400-2

5 x 96-well plate

 $2,750.00
$3,055.00

Specifications

Compatibility: Tissue Culture Media, Serum
ELISA Assay Range: 15.6 - 1000 pg/ml
Speed: Incubation time, 3 hours, 15 minutes
Specificity: Mouse Interferon Beta (No cross-reactivity against human IFN-α, IFN-γ, IFN-κ, IFN-β; mouse IFN-α, IFN-γ; rat IFN-α, IFN-γ, IFN-β; feline IFN-α; or pig IFN-α.)
Synonyms: Mouse Beta Interferon, Mouse IFN Beta, Mouse Type I IFN beta, Mouse Fibroblast IFN, Mouse Fibroblast Interferon, Mouse Beta IFN, Mouse Type I Interferon Beta
 
Inter-Assay CV: < 8%
Intra-Assay CV: < 8%
Spike Recovery: > 94%
 
Storage: 2-8°C
Expiration Date: One year from date of manufacture
Shipping Condition: Wet Ice

Materials Provided:

  • Pre-coated microtiter plate
  • Plate Sealers
  • Wash Solution Concentrate
  • Mouse Interferon Beta Standard, 500,000 pg/ml
  • Dilution Buffer 
  • Antibody Concentrate 
  • HRP Conjugate Concentrate 
  • Concentrate Diluent
  • TMB Substrate 
  • Stop Solution 

Tech Info / Data

Tips, Tools and Troubleshooting:

Detailed Related Product Information:

Background: 

The VeriKine Mouse Interferon Beta ELISA Kit has been developed to quantitate levels of IFN-β in tissue culture media or serum samples in a sandwich enzyme linked immunosorbent assay (ELISA) format with recombinant mouse IFN-beta expressed in mammalian cells provided as the standard in the kit. Interferons bind to plates coated with antibody and detection is accomplished using a secondary antibody followed by streptavidin conjugated to horseradish peroxidase (HRP). This ELISA kit utilizes Tetramethyl-benzidine (TMB) as the substrate.

Interferons (IFNs) are a group of cytokines which exhibit pleitropic activities that play major roles in both innate and adaptive immunity. Type 1 IFNs consist of multiple Interferon Alpha (IFN-α) genes and at least one Interferon Beta (IFN-β) gene in most vertebrates.

IFN-β is primarily known for its antiviral activity, but also has anti-proliferative, anti-inflammatory and immune-modulatory effects. It plays a pivotal role in the protective response to many infections and diseases, but when over expressed or produced unchecked it can also contribute to the generation of clinically relevant side effects and pathological processes. IFN-β is a common therapeutic treatment for multiple sclerosis and some cancers with the research into these diseases often conducted in mice.

Citations

​120 Citations:

  1. Abraham, Rachy, et al. (2020). Both ADP-Ribosyl-Binding and Hydrolase Activities of the Alphavirus nsP3 Macrodomain Affect Neurovirulence in Mice. mBio, 21 pgs. PMID: 32047134. (link)

  2. Brazee, Patricia, et al. (2019). Linear ubiquitin assembly complex regulates lung epithelial driven responses during influenza infection. JCI, 36 pgs. PMID: 31714898. (link)

  3. Sharma, Kiran, et al. (2019). Quantitative Proteome Analysis of Atg5-Deficient Mouse Embryonic Fibroblasts Reveals the Range of the Autophagy-Modulated Basal Cellular Proteome. mSystems, 20 pgs. PMID: 31690592. (link)

  4. Tegtmeyer, et al. (2019). STING induces early IFN-β in the liver and constrains myeloid cell-mediated dissemination of murine cytomegalovirus. Nature Communications, 12 pgs. PMID: 31249303. (link)

  5. Kim, et al. (2019). Small Heterodimer Partner Controls the Virus-Mediated Antiviral Immune Response by Targeting CREB-Binding Protein in the Nucleus. Cell Reports, 20 pgs. PMID: 31091449. (link)

  6. da Costa, et al. (2019). RNA viruses promote activation of the NLRP3 inflammasome through cytopathogenic effect-induced potassium efflux. Cell Death & Disease, 15 pgs. PMID: 31024004. (link)

  7. Mutso, Margit, et al. (2019). Analysis of Functional Virus-generated PAMP RNAs Using IFNα/β ELISA Assay. Bio-Protocol, 9 pgs. PMID: no PMID. (link)

  8. Li, Senlin, et al. (2018). The Cyclopeptide Astin C Specifically Inhibits the Innate Immune CDN Sensor STING. Cell Reports, 25 pgs. PMID: 30566866. (link)

  9. Kim, Sung Phil, et al. (2018). The composition of a bioprocessed shiitake (Lentinus edodes) mushroom mycelia and rice bran formulation and its antimicrobial effects against Salmonella enterica subsp. enterica serovar Typhimurium strain SL1344 in macrophage cells and in mice. BMC Complementary and Alternative Medicine, 12 pgs. PMID: 30518352. (link)

  10. Rani, Richa, et al. (2018). Mechanisms of Concanavalin A-Induced Cytokine Synthesis by Hepatic Stellate Cells: Distinct Roles of Interferon Regulatory Factor-1 in Liver Injury. JBC, 23 pgs. PMID: 30348900. (link)

  11. Liu, Xiang, et al. (2018). Decreased Virulence of Ross RIver Virus Harboring a Mutation in the First Cleavage Site of Nonstructural Polyprotein is Caused by a Novel Mechanism Leading to Increased Production of Interferon-Inducing RNAs. mBio, 15 pgs. PMID: 30131356. (link)

  12. Kao, Jo-Chi, et al. (2018). The antiparasitic drug niclosamide inhibits dengue virus infection by interfering with endosomal acidification independent of mTOR. PLOS Neglected Tropical Diseases, 16 pgs. PMID: 30125275. (link)

  13. Francica, Brian, et al. (2018). TNFα and Radioresistant Stromal Cells Are Essential for Therapeutic Efficacy of Cyclic Dinucleotide STING Agonists in Nonimmunogenic Tumors. Cancer Immunology Research, 25 pgs. PMID: 29472271. (link)

  14. Yi, Young-Su, et al. (2018). p204 is Required for Canonical Lipopolysaccharide-Induced TLR4 Signaling in Mice. EBioMedicine, 14 pgs. PMID: 29472103. (link)

  15. Czerkies, Maciej, et al. (2018). Cell Fate in Antiviral Response Arises in the Crosstalk of IRF, NF-kappa-B and JAK/STAT Pathways. Nature Communications, 14 pgs. PMID: 29402958. (link)

  16. Xia, Hongjie, et al. (2018). An Evolutionary NS1 Mutation Enhances Zika Virus Evasion of Host Interferon Induction. Nature Communications, 13 pgs. PMID: 29379028. (link)

  17. Tazaki, Taiyu, et al. (2018). Shape-dependent adjuvanticity of nanoparticle-conjugated RNA adjuvants for intranasal inactivated influenza vaccines. Royal Society of Chemistry, 10 pgs. PMID: no PMID. (link)

  18. Goetzke, Carl (2018). Die Bedeutung des Low Molecular Weight Protein 7 (LMP7) - Spezifischen Inhibitors ONX 0914 bei der Viralen Infektion der Maus. Universitaetsmedizin Berlin, 41 pgs. PMID: no PMID. (link)

  19. Odkhuu, Erdenezaya, et al. (2018). Sendai virus C protein limits NO production in infected RAW264.7 macrophages. Innate Immunity, 9 pgs. PMID: no PMID. (link)

  20. Hanagata, Nobutaka, et al. (2017). Double-Stranded Phosphodiester Cytosine-Guanine Oligodeoxynucleotide Complexed with Calcium Phosphate as a Potent Vaccine Adjuvant for Activating Cellular and Th I-Type Humoral Immunities. International Journal of Nanomedicine, 20 pgs. PMID: 29317815. (link)

  21. Lai, Chih-Yun, et al. (2017). Ebola Virus Glycoprotein Induces an Innate Immune Response In Vivo via TLR4. Frontiers in Microbiology, 15 pgs. PMID: 28861075. (link)

  22. Dhondup, et al. (2017). Toll-Like Receptor 9 Promotes Survival in SERCA2a KO Heart Failure Mice. Mediators of Inflammation, 12 pgs. PMID: 28490840. (link)

  23. Vermillion, Meghan, et al. (2017). Intrauterine Zika Virus Infection of Pregnant Immunocompetent Mice Models Transplacental Transmission and Adverse Perinatal Outcomes. Nature Communications, 14 pgs. PMID: 28220786. (link)

  24. Jin, Chang Hyun, et al. (2017). Comparison of the Anti-Inflammatory Activities of Supercritical Carbon Dioxide versus Ethanol Extracts from Leaves of Perilla frutescens Britt. Radiation Mutant. Molecules, 10 pgs. PMID: 28218690. (link)

  25. Kindler, Eveline, et al. (2017). Early Endonuclease-Mediated Evasion of RNA Sensing Ensures Efficient Coronavirus Replication. PLOS Pathogens, 27 pgs. PMID: 28158275. (link)

  26. Fuglsang, Eva, et al. (2017). Enhancement of Ceramide Formation Increases Endocytosis of Lactobacillus acidophilus and Leads to Increased IFN-Beta and IL-12 Production in Dendritic Cells. Journal of Clinical Immunology Research, 9 pgs. PMID: no PMID. (link)

  27. Shinde, Paurvi (2017). Investigating the Role of Lipopolysaccharide and Polyinosinic:Polycytidylic Acid in Boosting CD4 T Cell Responses. University of Connecticut, 173 pgs. PMID: no PMID. (link)

  28. Bloodworth, Melissa (2017). Regulation of immune responses during airway inflammation. Graduate School of Vanderbilt University, 161 pgs. PMID: no PMID. (link)

  29. Kindler, et al. (2016). Early Endonuclease-Mediated Evasion of RNA Sensing Ensures Efficient Coronavirus Replication. PLOS Pathogens, 26 pgs. PMID: 28158275. (link)

  30. Liu, Bingyu, et al. (2016). The ubiquitin E3 ligase TRIM31 promotes aggregation and activation of the signaling adaptor MAVS through Lys63-linked polyubiquitination. Nature Immunology. PMID: 27992402. (link)

  31. Spaulding, et al. (2016). STING-Licensed Macrophages Prime Type I IFN Production by Plasmacytoid Dendritic Cells in the Bone Marrow During Severe Plasmodium yoelii Malaria. PLOS Pathogens, 29 pgs. PMID: 27792766. (link)

  32. Ammayappan, et al. (2016). Recombinant Mumps Virus as a Cancer Therapeutic Agent. Molecular Therapy-Oncolytics, 10 pgs. PMID: 27556105. (link)

  33. So, Yangkang, et al. (2016). Rosmarinic Acid Methyl Ester Inhibits LPS-Induced NO Production via Suppression of MyD88- Dependent and -Independent Pathways and Induction of HO-1 in RAW 264.7 Cells. Molecules, 15 pgs. PMID: 27548124. (link)

  34. Pourcelot, Marie, et al. (2016). The Golgi apparatus acts as a platform for TBK1 activation after viral RNA sensing. BMC Biology, 17 pgs. PMID: 27538435. (link)

  35. Tang, Hai-Bo, et al. (2016). Viperin inhibits rabies virus replication via reduced cholesterol and sphingomyelin and is regulated upstream by TLR4. Scientific Reports, 12 pgs. PMID: 27456665. (link)

  36. Schmid, Edward, et al. (2016). AXL Receptor Tyrosine Kinase is Required for T Cell Priming and Antiviral Immunity. eLIFE, 18 pgs. PMID: 27350258. (link)

  37. Niendorf, Sandra, et al. (2016). Infection with the Persistent Murine Norovirus Strain MNV-S99 Suppresses IFN-Beta Release and Activation of Stat1 In Vitro. PLOS One, 13 pgs. PMID: 27294868. (link)

  38. Zhang, Liyong, et al. (2016). Interferon β (IFN-β) Production during the Double-stranded RNA (dsRNA) Response in Hepatocytes Involves Coordinated and Feedforward Signaling through Toll-like Receptor 3 (TLR3), RNA-dependent Protein Kinase (PKR), Inducible Nitric Oxide Synthase (iNOS), and Src Protein. JBC, 16 pgs. PMID: 27226571. (link)

  39. Hou, Zhaohua, et al. (2016). Hepatitis B Virus Inhibits Intrinsic TIG-I and RIG-G Immune Signaling via Inducing miR146a. Scientific Reports, 12 pgs. PMID: 27210312. (link)

  40. Cho, In-Jin, et al. (2016). Effects of C-reactive protein on bone cells. Life Sciences, 8 pgs. PMID: 26687448. (link)

  41. Liu, Li-Wen, et al. (2016). An RNA Molecule Derived From Sendai Virus DI Particles Induces Antitumor Immunity and Cancer Cell-selective Apoptosis. Molecular Therapy, 11 pgs. PMID: 26548591. (link)

  42. Birdwell, Lester (2016). Interactions of the Oas-Rnase L Pathway with Murine Coronavirus. University of Pennsylvania, 135 pgs. PMID: no PMID. (link)

  43. Rivera-Toledo, Evelyn, et al. (2015). Respiratory Syncytial Virus Persistence in Murine Macrophages Impairs IFN-β Response but Not Synthesis. Viruses, 14 pgs. PMID: 26501312. (link)

  44. Kumar, Mukesh, et al. (2015). Induction of Virus-Specific Effector Immune Cell Response Limits Virus Replication and Severe Disease in Mice Infected with Non-Lethal West Nile Virus Eg101 Strain. Journal of Neuroinflammation, 14 pgs. PMID: 26392176. (link)

  45. Hatchwell, Luke, et al. (2015). Toll-like receptor 7 governs interferon and inflammatory responses to rhinovirus and is suppressed by IL-5-induced lung eosinophilia. Thorax, 8 pgs. PMID: 26108570. (link)

  46. Totura, Allison, et al. (2015). Toll-Like Receptor 3 Signaling via TRIF Contributes to a Protective Innate Immune Response to Severe Acute Respiratory Syndrome Coronavirus Infection. mBio, 14 pgs. PMID: 26015500. (link)

  47. Ng, Cherie, et al. (2015). Blockade of Interferon Beta, but Not Interferon Alpha, Signaling Controls Persistent Viral Infection. Cell Host & Microbe, 10 pgs. PMID: 25974304. (link)

  48. Corrales, Leticia, et al. (2015). Direct Activation of STING in the Tumor Microenvironment Leads to Potent and Systemic Tumor Regression and Immunity. Cell Reports, 30 pgs. PMID: 25959818. (link)

  49. Reynaud, Josephine, et al. (2015). IFIT1 Differentially Interferes with Translation and Replication of Alphavirus Genomes and Promotes Induction of Type I Interferon. PLOS Pathogens, 31 pgs. PMID: 25927359. (link)

  50. Zhu, et al. (2015). Pattern recognition receptor-initiated innate antiviral responses in mouse epididymal epithelial cells. Journal of Immunology. PMID: 25840915. (link)

  51. Park, Sun Hong, et al. (2015). IRAK4 as a molecular target in the amelioration of innate immunity-related endotoxic shock and acute liver injury by chlorogenic acid. Journal of Immunology, 10 pgs. PMID: 25548221. (link)

  52. Detje, Claudia, et al. (2015). Upon Intranasal Vesicular Stomatitis Virus Infection, Astrocytes in the Olfactory Bulb Are Important Interferon Beta Producers That Protect from Lethal Encephalitis. JVI, 8 pgs. PMID: 25540366. (link)

  53. Ranjan, Priya, et al. (2015). NLRC5 interacts with RIG-I to induce a robust antiviral response against influenza virus infection. European Journal of Immunology, 15 pgs. PMID: 25404059. (link)

  54. Zaru, Rossana, et al. (2015). Structural and functional basis for p38-MK2-activated Rsk signaling in toll-like receptor-stimulated dendritic cells. Molecular & Cellular Biology, 9 pgs. PMID: 25332232. (link)

  55. Kanagavelu, et al. (2015). TIR-domain-containing adapter-inducing interferon-β (TRIF) regulates Th17-mediated intestinal immunopathology in colitis. Nature, 11 pgs. PMID: 25073675. (link)

  56. Martikainen, Miika (2015). Identifying Virus-Host Interactions Critical for Alphavirus-Mediated Oncolysis. University of Eastern Finland, 92 pgs. PMID: no PMID. (link)

  57. Ma, Chi, et al. (2015). Involvement of DNA-PKcs in the Type I IFN Response to CpG-ODNs in Conventional Dendritic Cells in TLR9-Dependent or -Independent Manners. PLOS One, 18 pgs. PMID: no PMID. (no link)

  58. Wolferstaetter, Michael, et al. (2014). Recombinant Modified Vaccinia Virus Ankara Generating Excess Early Double-Stranded RNA Transiently Activates Protein Kinase R and Triggers Enhanced Innate Immune Responses. JVI, 15 pgs. PMID: 25297997. (link)

  59. Liao, Juan, et al. (2014). An Image-Based Genetic Assay Identifies Genes in T1D Susceptibility Loci Controlling Cellular Antiviral Immunity in Mouse. PLOS One, 12 pgs. PMID: 25268627. (link)

  60. Desch, Nicole A, et al (2014). Dendritic cell subsets require cis-activation for cytotoxic CD8 T-cell induction. Nature Communications, 12 pgs. PMID: 25135627. (link)

  61. Kim, Dal Young, et al. (2014). Enhancement of Protein Expression by Alphavirus Replicons by Designing Self-Replicating Subgenomic RNAs. PNAS, 14 pgs. PMID: 25002490. (link)

  62. Dinis, Marcia, et al. (2014). The Innate Immune Response Elicited by Group A Streptococcus Is Highly Variable among Clinical Isolates and Correlates with the emm Type. PLOS One, 7 pgs. PMID: 24991887. (link)

  63. Dulek, Daniel E, et al (2014). STAT4 deficiency fails to induce lung Th2 or Th17 immunity following primary or secondary respiratory syncytial virus (RSV) challenge but enhances the lung RSV-specific CD8+ T cell immune response to secondary challenge. JVI, 18 pgs. PMID: 24920804. (link)

  64. Yamane, Kazuhiko, et al. (2014). Diisopropylamine Dichloroacetate, a Novel Pyruvate Dehydrogenase Kinase 4 Inhibitor, as a Potential Therapeutic Agent for Metabolic Disorders and Multiorgan Failure in Severe Influenza. PLOS One, 13 pgs. PMID: 24865588. (link)

  65. Esen, Nilufer, et al. (2014). Type-I Interferons Suppress Microglial Production of the Lymphoid Chemokine, CXCL13. GLIA, 11 pgs. PMID: 24829092. (link)

  66. Bosmann, Markus, et al. (2014). Tyrosine kinase 2 promotes sepsis-associated lethality by facilitating production of interleukin-27. JLB. PMID: 24604832. (link)

  67. Cai, Xinming, et al. (2014). PIKfyve, a class III lipid kinase, is required for TLR-induced type I IFN production via modulation of ATF3. Journal of Immunology, 8 pgs. PMID: 24600036. (link)

  68. Yang, K, et al. (2013). Functional RIG-I-Like Receptors Control the Survival of Mesenchymal Stem Cells. Cell Death and Disease, 11 pgs. PMID: 24336087. (link)

  69. Crotta, Stefania, et al. (2013). Type I and Type III Interferons Drive Redundant Amplification Loops to Induce a Transcriptional Signature in Influenza-Infected Airway Epithelia. PLOS Pathogens, 12 pgs. PMID: 24278020. (link)

  70. Thomsen, Martin, et al. (2013). JUNB/AP-1 Controls IFN-Gamma During Inflammatory Liver Disease. JCI, 11 pgs. PMID: 24200694. (link)

  71. Nikonov, Andrei, et al. (2013). RIG-I and MDA-5 Detection of Viral RNA-dependent RNA Polymerase Activity Restricts Positive-Strand RNA Virus Replication. PLOS Pathogens, 23 pgs. PMID: 24039580. (link)

  72. Lee, Myeong Sup, et al. (2013). Negative Regulation of Type I IFN Expression by OASL1 Permits Chronic Viral Infection and CD8+ T-Cell Exhaustion. PLOS Pathogens, 14 pgs. PMID: 23874199. (link)

  73. Nguyen, Cuong, et al. (2013). The Interferon-Signature of Sjögren’s Syndrome: How Unique Biomarkers Can Identify Underlying Inflammatory and Immunopathological Mechanisms of Specific Diseases. Frontiers in Immunology, 7 pgs. PMID: 23847613. (link)

  74. Ordureau, Alban, et al. (2013). DEAF1 is a Pellino1-Interacting Protein Required for Interferon Production by Sendai Virus and Double Stranded RNA. JBC, 22 pgs. PMID: 23846693. (link)

  75. Goulet, Marie-Line, et al. (2013). Systems Analysis of a RIG-I Agonist Inducing Broad Spectrum Inhibition of Virus Infectivity. PLOS Pathogens, 19 pgs. PMID: 23633948. (link)

  76. Menasria, Rafik, et al. (2013). Both TRIF and IPS-1 Adaptor Proteins Contribute to the Cerebral Innate Immune Response Against Herpes Simplex Virus 1 Infection. JVI, 9 pgs. PMID: 23596298. (link)

  77. Zhang, Weijuan, et al. (2013). DNA-dependent activator of interferon-regulatory factors (DAI) promotes lupus nephritis by activating the calcium pathway. JBC, 18 pgs. PMID: 23553627. (link)

  78. Ahn, Jeonghyun, et al. (2013). STING manifests self DNA-dependent inflammatory disease. PNAS, 6 pgs. PMID: 23132945. (link)

  79. Ferguson, Brian J, et al. (2012). DNA-PK is a DNA sensor for IRF-3-dependent innate immunity. eLIFE, 17 pgs. PMID: 23251783. (link)

  80. Chen, Kuan-Ru, et al. (2012). TBK1-associated protein in endolysosomes (TAPE)/CC2D1A is a key regulator linking RIG-I-like receptors to antiviral immunity. JBC, 7 pgs. PMID: 22833682. (link)

  81. Mazaleuskaya, Liudmila, et al. (2012). Protective Role of Toll-Like Receptor 3-Induced Type I Interferon in Murine Coronavirus Infection of Macrophages. Viruses, 23 pgs. PMID: 22754655. (link)

  82. Irie, Takashi, et al. (2012). Inhibition of Interferon Regulatory Factor 3 Activation by Paramyxovirus V Protein. JVI, 11 pgs. PMID: 22532687. (link)

  83. Moon, Ho-Jin, et al. (2012). Induction of Type I Interferon by High-Molecular Poly-Gamma-Glutamate Protects B6.A2G-Mx1 Mice Against Influenza A Virus. Antiviral Research, 5 pgs. PMID: 22401806. (link)

  84. Frolov, Ilya, et al. (2012). Early Events in Alphavirus Replication Determine the Outcome of Infection. JVI, 13 pgs. PMID: 22345447. (link)

  85. Wang, Jennifer, et al. (2012). Role of Specific Innate Immune Responses in Herpes Simplex Virus Infection of the Central Nervous System. JVI, 9 pgs. PMID: 22171256. (link)

  86. Ng, Ming-Him, et al. (2011). MIP-T3 is a Negative Regulator of Innate Type I IFN Response. Journal of Immunology, 11 pgs. PMID: 22079989. (link)

  87. Teijaro, John, et al. (2011). Endothelial Cells are Central Orchestrators of Cytokine Amplification During Influenza Virus Infection. CellPress, 32 pgs. PMID: 21925319. (link)

  88. Mack, Ethan, et al. (2011). Type 1 Interferon Induction of Natural Killer Cell Gamma Interferon Production for Defense during Lymphocytic Choriomeningitis Virus Infection. mBio, 10 pgs. PMID: 21828218. (link)

  89. Sander, Leif, et al. (2011). Sensing prokaryotic mRNA signifies microbial viability and promotes immunity. Nature, 20 pgs. PMID: 21602824. (link)

  90. Janelle, Valerie, et al. (2011). Mutations in the Glycoprotein of Vesicular Stomatitis Virus Affect Cytopathogenicity: Potential for Oncolytic Virotherapy. JVI, 9 pgs. PMID: 21561919. (link)

  91. Solodova, Evgenia, et al. (2011). Production of IFN-Beta During Listeria monocytogenes Infection is Restricted to Monocyte/Macrophage Lineage. PLOS One, 10 pgs. PMID: 21494554. (link)

  92. Burnette, Byron, et al. (2011). The Efficacy of Radiotherapy Relies upon Induction of Type I Interferon −Dependent Innate and Adaptive Immunity. Cancer Research, 16 pgs. PMID: 21300764. (link)

  93. Bourgeois, Christelle, et al. (2011). Conventional Dendritic Cells Mount a Type I IFN Response Against Candida spp. Requiring Novel Phagosomal TLR7-Mediated IFN-Beta Signaling. Journal of Immunology, 10 pgs. PMID: 21282509. (link)

  94. Broquet, Alexis, et al. (2011). RIG-I/MDA5/MAVS Are Required To Signal a Protective IFN Response in Rotavirus-Infected Intestinal Epithelium. Journal of Immunology, 10 pgs. PMID: 21187438. (link)

  95. Cheng, Gaunjun, et al. (2011). Pharmacologic Activation of the Innate Immune System to Prevent Respiratory Viral Infections. American Thoracic Society, 9 pgs. PMID: 21148741. (link)

  96. Leu, Shaw-Wei, et al. (2011). TLR4 through IFN-β promotes low molecular mass hyaluronan-induced neutrophil apoptosis. Journal of Immunology, 8 pgs. PMID: 21098223. (link)

  97. Guerra, Susana, et al. (2010). Selective induction of host genes by MVA-B, a candidate vaccine against HIV/AIDS. JVI, 12 pgs. PMID: 20534857. (link)

  98. Kaczorowski, David, et al. (2010). Pivotal Advance: The pattern recognition receptor ligands lipopolysaccharide and polyinosine-polycytidylic acid stimulate factor B synthesis by the macrophage through distinct but overlapping mechanisms. JLB, 10 pgs. PMID: 20413727. (link)

  99. Abraham, Anson, et al. (2010). Type I Interferon Receptor is a Primary Regulator of Target- Mediated Drug Disposition of Interferon-Beta in Mice. The Journal of Pharmacology and Experimental Therapeutics, 6 pgs. PMID: 20406858. (link)

  100. Watanabe, Tomohiro, et al. (2010). NOD1 contributes to mouse host defense against Helicobacter pylori via induction of type I IFN and activation of the ISGF3 signaling pathway. JCI, 18 pgs. PMID: 20389019. (link)

  101. Schilte, Clementine, et al. (2010). Type I IFN controls chikungunya virus via its action on nonhematopoietic cells. JEM, 14 pgs. PMID: 20123960. (link)

  102. Yasukawa, Kai, et al. (2009). Mitofusin 2 inhibits mitochondrial antiviral signaling. Science Signaling, 12 pgs. PMID: 19690333. (link)

  103. Huys, Liesbeth, et al. (2009). Type I interferon drives tumor necrosis factor–induced lethal shock. JEM, 10 pgs. PMID: 19687227. (link)

  104. Seigemund, Sabine, et al. (2009). Conventional Bone Marrow-Derived Dendritic Cells Contribute to Toll-Like Receptor-Independent Production of Alpha/Beta Interferon in Response to Inactivated Parapoxvirus Ovis. JVI, 12 pgs. PMID: 19570869. (link)

  105. Yen, Jui-Hung, et al. (2009). Interferon β induces mature dendritic cell apoptosis through caspase-11/caspase-3 activation. Blood Journal. PMID: 19531658. (link)

  106. Ahmed, Maryam, et al. (2009). Vesicular Stomatitis Virus M Protein Mutant Stimulates Maturation of Toll-Like Receptor 7 (TLR7)-Positive Dendritic Cells through TLR-Dependent and -Independent Mechanisms. JVI, 14 pgs. PMID: 19144711. (link)

  107. Waibler, Zoe, et al. (2009). Vaccinia Virus-Mediated Inhibition of Type I Interferon Responses Is a Multifactorial Process Involving the Soluble Type I Interferon Receptor B18 and Intracellular Components▿ . JVI, 9 pgs. PMID: 19073732. (link)

  108. Roth-Cross, Jessica, et al. (2008). Murine Coronavirus Mouse Hepatitis Virus is Recognized by MDA5 and Induces Type I Interferon in Brain Macrophages/Microglia. JVI, 11 pgs. PMID: 18667505. (link)

  109. Zurney, Jennifer, et al. (2007). Basal expression levels of IFNAR and Jak-STAT components are determinants of cell-type-specific differences in cardiac antiviral responses. JVI, 13 pgs. PMID: 17942530. (link)

  110. Zetterstrom, et al. (2007). Pivotal advance: inhibition of HMGB1 nuclear translocation as a mechanism for the anti-rheumatic effects of gold sodium thiomalate. JLB, pgs. PMID: 17913975. (link)

  111. Qin, Lizeng, et al. (2007). Effects of Type I Interferons on the Adjuvant Properties of Plasmid Granulocyte-Macrophage Colony-Stimulating Factor In Vivo. JVI, 8 pgs. PMID: 17652387. (link)

  112. Yasuda, Kei, et al. (2007). Murine dendritic cell type I IFN production induced by human IgG-RNA immune complexes is IFN regulatory factor (IRF)5 and IRF7 dependent and is required for IL-6 production.. Journal of Immunology, 11 pgs. PMID: 17513736. (link)

  113. Roth-Cross, Jessica, et al. (2007). Inhibition of the Alpha/Beta Interferon Response by Mouse Hepatitis Virus at Multiple Levels. JVI, 11 pgs. PMID: 17459917. (link)

  114. Zhou, Rongbin, et al. (2007). Recognition of Double-Stranded RNA by TLR3 Induces Severe Small Intestinal Injury in Mice. Journal of Immunology, 10 pgs. PMID: 17372013. (link)

  115. Mumphrey, Shannon, et al. (2007). Murine Norovirus 1 Infection is Associated with Histopathological Changes in Immunocompetent Hosts, but Clinical Disease is Prevented by STAT1-Dependent Interferon Responses. JVI, 13 pgs. PMID: 17229692. (link)

  116. Douagi, Iyadh, et al. (2007). Role of Interferon Regulatory Factor 3 in Type I Interferon Responses in Rotavirus-Infected Dendritic Cells and Fibroblasts. JVI, 11 pgs. PMID: 17215281. (link)

  117. Saha, Supriya, et al. (2006). Regulation of antiviral responses by a direct and specific interaction between TRAF3 and Cardif. The EMBO Journal, 7 pgs. PMID: 16858409. (link)

  118. Kato, Hiroki, et al. (2006). Differential roles of MDA5 and RIG-I helicases in the recognition of RNA viruses. Nature, 6 pgs. PMID: 16625202. (link)

  119. Gitlin, Leonid, et al. (2005). Essential role of mda-5 in type I IFN responses to polyriboinosinic:polyribocytidylic acid and encephalomyocarditis picornavirus. PNAS, 6 pgs. PMID: 16714379. (link)

  120. Pewe, Lecia, et al. (2005). A Severe Acute Respiratory Syndrome-Associated Coronavirus-Specific Protein Enhances Virulence of an Attenuated Murine Coronavirus. JVI, 8 pgs. PMID: 16103185. (link)

References:

  1. Staehelin et al. (1981) Methods in Enzymology, Vol. 79. (Pestka, ed.), Academic Press, New York, 589-595.

  2. Balachandran et al. (2004) Nature, Vol. 432, 401-405.

Documentation

Typical Standard Curve from 15.6 to 1000 pg/ml for PBL's Mouse IFN Beta ELISA (42400)

 

Mouse IFN beta standard curve from 15.6 to 1000 pg/ml using PBL Mouse Interferon Beta ELISA (42400)

Assay Range: 15.6 - 1000 pg/ml

Related Products

Catalog No. Description Pack Size Price Quantity
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42410-2 VeriKine-HS Mouse Interferon Beta Serum ELISA Kit
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