Human IFN-Αlpha ELISA Subtype Specificities Comparison Chart

Generation of Type I interferons (IFNs) occurs downstream of a multitude of immunologic stimuli. The production of these cytokines can be either a positive prognostic, as in defensive immunity against a pathogenic insult, or a negative prognostic, as in promotion of autoimmunity.

In humans, the designation "IFN-Alpha" is used to represent a family of proteins comprised of at least 12 highly homologous protein subtypes that exhibit diverse biologic activities. IFN-Alpha can be used as a therapeutic agent in disease treatment regimens, as a downstream readout of the effectiveness of several drug therapies, and as a marker of pathology in human clinical and preclinical studies.

PBL's Human IFN-Alpha ELISA kits are in the forefront of providing accurate quantitation of IFN-Alpha. Below is a quick view of these kits' IFN-Alpha subtype specificities. For more detailed information such as LLOQs and LLODs of the All-Subtype VeriKine-HS kits, please visit individual product pages.

IFN
Cat. # 41115
All-Subtype Serum
Cat. # 41135
All-Subtype TCM
Cat. # 41110
Multi-Subtype Serum
Cat. # 41105
Multi-Subtype TCM
Cat. # 41100
TCM
IFN-αA +++ +++ ++ ++ ++
IFN-α2 +++ +++ ++ ++ ++
IFN-αA/D +++ +++ ++ ++ ++
IFN-αB2 +++ +++ ++ ++ -
IFN-αC +++ +++ ++ ++ +
IFN-αD +++ +++ ++ ++ ++
IFN-αF +++ +++ - - -
IFN-αG +++ +++ ++ ++ +
IFN-αH +++ +++ ++ ++ -
IFN-αI +++ +++ ++ ++ +
IFN-αJ1 +++ +++ ++ ++ +
IFN-αK +++ +++ ++ ++ ++
IFN-α1 +++ +++ ++ ++ ++
IFN-α4a +++ +++ + + +
IFN-αWA +++ +++ ++ ++ +
IFN-β - - - - -
IFN-γ - - - - -
IFN-ω - - - - -
Rhesus IFN-α2 + + +/- +/- +

Key:

+++ Very Good
++    Good
+      Moderate
-       Not at all
+/-    Nominal

Antibodies Against Human IFN-Αlpha Subtype Specificities Comparison Chart

IFN	Cat. # 41115 All-Subtype Serum	Cat. # 41135 All-Subtype TCM	Cat. # 41110 Multi-Subtype Serum	Cat. # 41105 Multi-Subtype TCM	Cat. # 41100 TCM
IFN-αA	+++	+++	++	++	++
IFN-α2	+++	+++	++	++	++
IFN-αA/D	+++	+++	++	++	++
IFN-αB2	+++	+++	++	++	-
IFN-αC	+++	+++	++	++	+
IFN-αD	+++	+++	++	++	++
IFN-αF	+++	+++	-	-	-
IFN-αG	+++	+++	++	++	+
IFN-αH	+++	+++	++	++	-
IFN-αI	+++	+++	++	++	+
IFN-αJ1	+++	+++	++	++	+
IFN-αK	+++	+++	++	++	++
IFN-α1	+++	+++	++	++	++
IFN-α4a	+++	+++	+	+	+
IFN-αWA	+++	+++	++	++	+
IFN-β	-	-	-	-	-
IFN-γ	-	-	-	-	-
IFN-ω	-	-	-	-	-
Rhesus IFN-α2	+	+	+/-	+/-	+

Human IFN-Αlpha ELISA Subtype Specificities Comparison Chart

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