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Human IFN-Αlpha ELISA Subtype Specificities Comparison Chart

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Generation of Type I interferons (IFNs) occurs downstream of a multitude of immunologic stimuli. The production of these cytokines can be either a positive prognostic, as in defensive immunity against a pathogenic insult, or a negative prognostic, as in promotion of autoimmunity.

In humans, the designation "IFN-Alpha" is used to represent a family of proteins comprised of at least 12 highly homologous protein subtypes that exhibit diverse biologic activities. IFN-Alpha can be used as a therapeutic agent in disease treatment regimens, as a downstream readout of the effectiveness f several drug therapies, and as a marker of pathology in human clinical and preclinical studies.

PBL's Human IFN-Alpha ELISA kits are in the forefront of providing accurate quantitation of IFN-Alpha. Below is a quick view of these kits' IFN-Alpha subtype specificities. For more detailed information such as LLOQs and LLODs of the All-Subtype VeriKine-HS kits, please visit individual product pages.

IFN

Cat. # 41115

All-Subtype Serum

Cat. # 41135

All-Subtype TCM

Cat. # 41110

Multi-Subtype Serum

Cat. # 41105

Multi-Subtype TCM

Cat. # 41100

TCM

IFN-αA +++ +++ ++ ++ ++
IFN-α2 +++ +++ ++ ++ ++
IFN-αA/D +++ +++ ++ ++ ++
IFN-αB2 +++ +++ ++ ++ -
IFN-αC +++ +++ ++ ++ +
IFN-αD +++ +++ ++ ++ ++
IFN-αF +++ +++ - - -
IFN-αG +++ +++ ++ ++ +
IFN-αH +++ +++ ++ ++ -
IFN-αI +++ +++ ++ ++ +
IFN-αJ1 +++ +++ ++ ++ +
IFN-αK +++ +++ ++ ++ ++
IFN-α1 +++ +++ ++ ++ ++
IFN-α4a +++ +++ + + +
IFN-αWA +++ +++ ++ ++ +
IFN-β - - - - -
IFN-γ - - - - -
IFN-ω - - - - -
Rhesus IFN-α2 + + +/- +/- +

 

 

Key:

 

+++  Very Good

++    Good

+      Moderate

-       Not at all

+/-    Nominal

 

 

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