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Delivers femtogram per milliliter (fg/ml) level sensitivity for measurement of low-abundance biomarkers in serum, plasma and other complex matrices including bronchial lavage, urine and sputum
Provides robust quantitative detection of various single analytes. Comprehensive multiplex panel options also available
Offers a high degree of precision, accuracy, and reproducibility with < 10% inter- and intra-assay CVs
Over 50 analytes to choose from including IL-17A, TNF-alpha, IL-23, IP-10, TRAIL, IL-6, IL-10 and IL-12p70
For an in-depth overview of the ultra-sensitive biomarker detection technology (Simoa), click here.
For additional information, please see the Ultra-Sensitive Biomarker Services Flyer.
Figure 1. Normal Human Serum (NHS) Endogenous Levels of Several Pro- and Anti-Inflammatory Cytokines
*The Representative Functional LLOQ is the assay’s Representative Analytical LLOQ corrected for a Recommended Sample Dilution Factor specific to each assay. Both the Representative Calibration Range and Functional LLOQ are often lot-specific.
Assay [Catalog No.] |
Species | Matrix | Representative Calibration Range | Representative Functional LLOQ | Datasheet |
---|---|---|---|---|---|
α-Synuclein [102233] Alpha Synuclein Discovery Assay Kit |
Human |
CSF, Plasma, Serum |
4.12 – 1,000 pg/mL |
41.2 pg/mL | Datasheet |
Aβ-40 [101672] Amyloid Beta 40 Advantage Assay Kit |
Human |
CSF, Plasma |
2.47 – 200 pg/mL |
CSF: 49.2 pg/mL P: 4.92 pg/mL |
Datasheet |
Aβ-42 [101664] Amyloid Beta 42 Advantage Assay Kit |
Human | CSF, Plasma | 0.137 – 100 pg/mL |
CSF: 1.37 pg/mL P: 0.548 pg/mL |
Datasheet |
BDNF [102039] |
Human |
CSF, Plasma, Serum |
0.029 – 120 pg/mL |
CSF: 0.059 pg/mL P: 14.65 pg/mL S: 14.65 pg/mL |
Datasheet |
c-MET [102073] c-MET Discovery Assay Kit |
Human |
Cell Lysates, Plasma, Serum |
0.488 – 2,000 pg/mL |
97.6 pg/mL |
Datasheet |
C-peptide [100199] Connecting Peptide Advantage Assay Kit |
Human |
Plasma, Serum |
0.137 – 100 pg/mL |
T1 Diabetes: 0.084 pg/mL T2 Diabetes: 0.21 pg/mL |
Datasheet |
CA-125 [102136] Cancer Antigen 125 Discovery Assay Kit |
Human | Plasma, Serum | 0.027 – 20 U/mL | Not Given | |
CA-19-9 [102543] Cancer Antigen 19-9 Discovery Assay Kit |
Human | Plasma, Serum | 0.165 – 120 U/mL | 0.082 U/mL | Datasheet |
Cathepsin S [102064] Cathepsin S Discovery Assay Kit |
Human | Plasma, Serum | 1.95 – 2,000 pg/mL | 195 pg/mL | Datasheet |
CEA [102556] Carcinoembryonic Antigen Discovery Assay Kit |
Human | Plasma, Serum | 2.33 – 1,700 pg/mL | 116.5 pg/mL | Datasheet |
CRP [102583] C-reactive Protein Discovery Assay Kit |
Human | Plasma, Serum | 1.37 – 1,000 pg/mL | 32.93 pg/mL | Datasheet |
cTnI [101588] Cardiac Troponin I Advantage Assay Kit |
Human | Plasma, Serum | 0.098 – 300 pg/mL | 0.316 pg/mL | Datasheet |
CXCL13 [102635] CXC Ligand 13 Protein Discovery Assay Kit |
Human | Plasma, Serum |
0.274 – 200 pg/mL |
0.28 pg/mL |
Datasheet |
C3PA [101160] Cytokine 3-Plex A Advantage Assay Kit (for IL-6, IL-10, TNF-α) |
Human | Plasma, Serum |
IL-6: 0.043 – 15 pg/mL IL-10: 0.023 – 6 pg/mL TNF-α: 0.088 – 28 pg/mL |
IL-6: 0.044 pg/mL IL-10: 0.292 pg/mL TNF-α: 0.204 pg/mL |
Datasheet |
C3PB [101319] Cytokine 3-Plex B Advantage Assay Kit (for IL-6, IL-17A, TNF-α) |
Human | Plasma, Serum |
IL-6: 0.048 – 15 pg/mL IL-17A: 0.05 –10 pg/mL TNF-α: 0.097 – 28 pg/mL |
IL-6: 0.092 pg/mL IL-17A: 0.028 pg/mL TNF-α: 0.104 pg/mL |
Datasheet |
Eotaxin [101212] Eotaxin Advantage Assay Kit |
Human | Plasma, Serum | 0.165 – 120 pg/mL | 0.72 pg/mL | Datasheet |
G-CSF [101235] Granulocyte Colony Stimulating Factor Advantage Assay Kit |
Human | Plasma, Serum | 0.274 – 200 pg/mL | 0.38 pg/mL | Datasheet |
GFAP™ [102336] Glial Fibrillary Acidic Protein Discovery Assay Kit |
Human | CSF, Plasma, Serum | 1.37 – 1,000 pg/mL |
CSF: 27.44 pg/mL P: 2.744 pg/mL S: 2.744 pg/mL
|
Datasheet |
GM-CSF [102329] Granulocyte Macrophage Colony-Stimulating Factor Advantage Assay Kit |
Human | Plasma, Serum | 0.041 – 30 pg/mL | 0.041 pg/mL | Datasheet |
HE-4/WFDC2 [103059] Human Epididymis Protein 4 Discovery Assay Kit |
Human | Plasma, Serum | 0.977 – 1,000 pg/mL | 3.908 pg/mL | Datasheet |
HIV p24 [102215] Human Immunodeficiency Virus Gag Protein 24 Advantage Assay Kit |
Human | Plasma, Serum | 0.01 – 30 pg/mL | 0.02 pg/mL | Datasheet |
IFN-α [100860] Interferon Alpha Advantage Assay Kit |
Human | Serum | 0.97 – 30 pg/mL | 0.009 pg/mL | Datasheet |
IFN-γ [103337] Interferon Gamma Advantage Assay Kit |
Human | Plasma, Serum | 0.049 – 50 pg/mL | 0.196 pg/mL | Datasheet |
IL-1α [101968] Interleukin 1 Alpha Discovery Assay Kit |
Human | Plasma, Serum | 0.041 – 30 pg/mL | 0.02 pg/mL | Datasheet |
IL-1α [102504] Interleukin 1 Alpha Discovery Assay Kit |
Mouse | Plasma, Serum | 0.096 – 70 pg/mL | 0.6 pg/mL | Datasheet |
IL-1β [101605] Interleukin 1 Beta Advantage Assay Kit |
Human | Plasma, Serum | 0.165 – 120 pg/mL | 0.166 pg/mL | Datasheet |
IL-1β [102109] Interleukin 1 Beta Discovery Assay Kit |
Mouse | Plasma, Serum | 1.01 – 160 pg/mL | 0.48 pg/mL | Datasheet |
IL-2 [101635] Interleukin 2 Advantage Assay Kit |
Human | Plasma, Serum | 0.123 – 30 pg/mL | 0.164 pg/mL | Datasheet |
IL-3 [102462] Interleukin 3 Discovery Assay Kit |
Human | Plasma, Serum | 0.686 – 500 pg/mL | 2.744 pg/mL | Datasheet |
IL-4 [100196] Interleukin 4 Advantage Assay Kit |
Human | Plasma, Serum | 0.137 – 100 pg/mL | 0.078 pg/mL | Datasheet |
IL-5 [102860] Interleukin 5 Advantage Assay Kit |
Human | Plasma, Serum | 0.016 – 12 pg/mL | 0.033 pg/mL | Datasheet |
IL-6 [101622] Interleukin 6 Advantage Assay Kit |
Human | Plasma, Serum | 0.041 – 30 pg/mL | 0.04 pg/mL | Datasheet |
IL-6 [102109] Interleukin 6 Discovery Assay Kit |
Mouse | Plasma, Serum | 1.012 – 160 pg/mL | 0.48 pg/mL | Datasheet |
IL-7 [103277] Interleukin 7 Advantage Assay Kit |
Human | Plasma, Serum | 0.206 – 150 pg/mL | 0.412 pg/mL | Datasheet |
IL-8 [100198] |
Human | Plasma, Serum | 0.073 – 300 pg/mL | 0.368 pg/mL | Datasheet |
IL-10 [101643] Interleukin 10 Advantage Assay Kit |
Human | Plasma, Serum | 0.041 – 30 pg/mL | 0.084 pg/mL | Datasheet |
IL-12p40/IL-23 [101871] Interleukin 8 Advantage Assay Kit |
Human | Plasma, Serum | 0.343 – 250 pg/mL | 0.344 pg/mL | Datasheet |
IL-12p70 [100988] Interleukin 12p70 Advantage Assay Kit |
Human | Plasma, Serum | 0.014 – 10 pg/mL | 0.068 pg/mL | Datasheet |
IL-13 [102732] Interleukin 13 Advantage Assay Kit |
Human | Plasma, Serum | 0.004 – 15 pg/mL | 0.01 pg/mL | Datasheet |
IL-15 [100794] Interleukin 15 Advantage Assay Kit |
Human | Plasma, Serum | 0.014 – 10 pg/mL | 0.0248 pg/mL | Datasheet |
IL-17A [101599] Interleukin 17A Advantage Assay Kit |
Human | Plasma, Serum | 0.041 – 30 pg/mL | 0.084 pg/mL | Datasheet |
IL-17A [101824] Interleukin 17A Advantage Assay Kit |
Mouse | Plasma, Serum | 0.97 – 300 pg/mL | 1.648 pg/mL | Datasheet |
IL-17C [102570] Interleukin 17C Discovery Assay Kit |
Human | Plasma, Serum | 0.412 – 300 pg/mL | 0.824 pg/mL | Datasheet |
IL-17F [101839] Interleukin 17F Discovery Assay Kit |
Mouse | Plasma, Serum | 1.01 – 600 pg/mL | 1.648 pg/mL | Datasheet |
IL-18 [102700] Interleukin 18 Discovery Assay Kit |
Human | Plasma, Serum | 0.011 – 45 pg/mL | 0.6 pg/mL | Datasheet |
IL-22 [103071] Total Interleukin 22 Discovery Assay Kit |
Human | Plasma, Serum | 0.041 – 30 pg/mL | 0.041 pg/mL | Datasheet |
IL-22 [101919] Interleukin 22 Discovery Assay Kit |
Mouse | Plasma, Serum | 0.982 – 300 pg/mL | 0.824 pg/mL | Datasheet |
IL-23 [101847] Interleukin 23 Discovery Assay Kit |
Mouse | Plasma, Serum | 0.964 – 200 pg/mL | 0.548 pg/mL | Datasheet |
IL-28A [101419] Interleukin 28A Discovery Assay Kit |
Human | Plasma, Serum | 0.137 – 100 pg/mL | 0.138 pg/mL | Datasheet |
IL-33 [103093] Interleukin 33 Discovery Assay Kit |
Human | Plasma, Serum | 1.372 – 1,000 pg/mL | 1.372 pg/mL | Datasheet |
IL-36β [101808] Interleukin 36 Beta Discovery Assay Kit |
Human | Plasma, Serum | 0.206 – 150 pg/mL | 0.824 pg/mL | Datasheet |
IP-10 [101132] |
Human | Plasma, Serum | 0.274 – 200 pg/mL | 0.708 pg/mL | Datasheet |
LIF [102394] Leukemia Inhibitory Factor Discovery Assay Kit |
Human |
Plasma, Serum | 0.981 – 120 pg/mL | 0.344 pg/mL | Datasheet |
MCP-1 [101154] Monocyte Chemoattractant Protein 1 Advantage Assay Kit |
Human | Plasma, Serum | 0.823 – 200 pg/mL | 0.612 pg/mL | Datasheet |
MCP-3 [102382] Monocyte Chemoattractant Protein 3 Discovery Assay Kit |
Human | Plasma, Serum | 0.309 – 225 pg/mL | 0.618 pg/mL | Datasheet |
MMP-9 [102491] Matrix Metalloproteinase 9 Discovery Assay Kit |
Human | CSF, Platelet-Poor Heparin Plasma, Serum | 4.88 – 5,000 pg/mL |
CSF: 39.04 pg/mL P: 4,880 pg/mL S: 4,880 pg/mL
|
Datasheet |
N2PB [103520] Neurology 2-Plex B Advantage Assay Kit (for GFAP, NF-Light) |
Human | CSF, Plasma, Serum |
GFAP: 10 – 9,000 pg/mL NF-L: 0.5 – 450 pg/mL |
(in Plasma) GFAP: 16.6 pg/mL NF-L: 0.8 pg/mL |
Datasheet |
N3PA [101995] Neurology 3-Plex A Advantage Assay Kit (for Aβ-40, Aβ-42, Tau) |
Human | CSF, Plasma, Serum |
Aβ-40: 0.777 – 130 pg/mL Aβ-42: 0.18 – 64 pg/mL Tau: 0.1 – 100 pg/mL |
(in Plasma) Aβ-40: 2.7 pg/mL Aβ-42: 0.568 pg/mL Tau: 0.252 pg/mL |
Datasheet |
N4PA [102153] Neurology 4-Plex A Advantage Assay Kit (for GFAP, NF-Light, Tau, UCH-L1) |
Human | CSF, Plasma, Serum |
GFAP: 1.02 – 1,000 pg/mL NF-L: 0.554 – 500 pg/mL Tau: 0.123 – 100 pg/mL UCH-L1: 13.8 – 10,000 pg/mL |
(in Plasma) GFAP: 1.868 pg/mL NF-L: 0.964 pg/mL Tau: 0.5 pg/mL UCH-L1: 37.52 pg/mL |
|
N4PB [103345] Neurology 4-Plex B Advantage Assay Kit (for GFAP, NF-Light, Tau, UCH-L1) |
Human | CSF, Plasma, Serum |
GFAP: 10 – 9,000 pg/mL NF-L: 0.50 – 450 pg/mL Tau: 0.1 – 90 pg/mL UCH-L1: 10 – 9,000 pg/mL |
(in Plasma) GFAP: 37.52 pg/mL NF-L: 2 pg/mL Tau: 0.5 pg/mL UCH-L1: 37.52 pg/mL |
Datasheet |
NF-LIGHT® [103186] |
Human | CSF, EDTA Plasma, Heparin Plasma, Serum | 0.538 – 500 pg/mL |
CSF: 17.4 pg/mL P: 0.696 pg/mL S: 0.696 pg/mL |
Datasheet |
NSE [102475]
|
Human | Plasma, Serum | 9.88 – 2,400 pg/mL | 494 pg/mL | Datasheet |
NT-proBNP [102713] N-Terminal Pro B Type Natriuretic Peptide Discovery Assay Kit |
Human | Plasma, Serum | 0.206 – 50 pg/mL | 2.06 pg/mL | Datasheet |
PD-1 [102929] Programmed Cell Death Protein 1 Discovery Assay Kit |
Human | Plasma, Serum | 1.76 – 1,800 pg/mL | 3.516 pg/mL | Datasheet |
PD-L1 [102648] Programmed Death Ligand 1 Discovery Assay Kit |
Human | Plasma, Serum | 0.885 – 215 pg/mL | 2.1 pg/mL | Datasheet |
PLGF [102318] Placental Growth Factor Discovery Assay Kit |
Human | Plasma, Serum | 0.329 – 240 pg/mL | 1.2 pg/mL | Datasheet |
pNF-Heavy [102669] Phosphorylated Neurofilament-Heavy Discovery Assay Kit |
Human |
(Human) CSF, Plasma, Serum (Mouse) Plasma, Serum |
2.88 – 2,100 pg/mL |
(H)CSF: 72 pg/mL (H)P: 11.52 pg/mL (H)S: 11.52 pg/mL (M)P: 28.8 pg/mL (M)S: 28.8 pg/mL |
Datasheet |
PSA [101478] |
Human | Plasma, Serum | 0.1 – 100 pg/mL | 0.096 pg/mL | Datasheet |
p-Tau 181 [103714] Tau Phosphorylated at Threonine 181 Advantage Assay Kit |
Human | CSF, Plasma, Serum | 0.169 – 103 pg/mL |
CSF: 0.67 pg/mL P: 0.268 pg/mL S: 0.268 pg/mL |
Datasheet |
p-Tau 231 [102292] Tau Phosphorylated at Threonine 231 Advantage Assay Kit |
Human | CSF | 0.41 – 300 pg/mL | 7.32 pg/mL | Datasheet |
Tau [101522] Tau Advantage Assay Kit |
Human | CSF, Plasma, Serum | 0.054 – 100 pg/mL |
CSF: 0.61 pg/mL P: 0.244 pg/mL S: 0.244 pg/mL |
Datasheet |
Tau [102209] Tau Discovery Assay Kit |
Mouse | CSF, Plasma, Serum | 0.823 – 600 pg/mL |
CSF: 8.23 pg/mL P: 3.292 pg/mL S: 3.292 pg/mL |
Datasheet |
TDP-43 [103293] |
Human | CSF, Plasma, Serum | 8.23 – 2,000 pg/mL | 32.92 pg/mL | Datasheet |
TGF-α [101863] Transforming Growth Factor Alpha Discovery Assay Kit |
Human | Plasma, Serum | 0.617 – 450 pg/mL | 0.414 pg/mL | Datasheet |
TGF-β [101984] Transforming Growth Factor Beta Discovery Assay Kit |
Human | Plasma, Serum | 2.06 – 1,500 pg/mL | 8.224 pg/mL | Datasheet |
TNF-α [101580] |
Human | Plasma, Serum | 0.069 – 50 pg/mL | 0.136 pg/mL | Datasheet |
TNF-α [102100] |
Mouse | Plasma, Serum | 2.47 – 1,800 pg/mL | 4.92 pg/mL | Datasheet |
TNF-β [102091] Tumor Necrosis Factor Beta Discovery Assay Kit |
Human | Plasma, Serum | 0.95 – 600 pg/mL | 0.6 pg/mL | Datasheet |
TRAIL [100906] Tumor Necrosis Factor-Related Apoptosis-Inducing Ligand Advantage Assay Kit |
Human | Plasma, Serum | 0.137 – 100 pg/mL | 0.072 pg/mL | Datasheet |
UCH-L1™ [102343] Ubiquitin C-Terminal Hydrolase L1 Discovery Assay Kit |
Human | CSF, Plasma, Serum | 6.86 – 5,000 pg/mL |
CSF: 34.3 pg/mL P: 13.72 pg/mL S: 13.72 pg/mL |
Datasheet |
VEGF [102794] Vascular Endothelial Growth Factor Discovery Assay Kit |
Human | Plasma, Serum | 0.274 – 200 pg/mL | 0.548 pg/mL | Datasheet |
PBL's Ultrasensitive Biomarker Testing Assay Services take advantage of the benefits of Single Molecule Array (Simoa) technology. This approach traps a single bead in low femtoliter-sized wells to allow “digital” measurement of each bead for the presence of analyte in a sandwich immunoassay. The enzymatic amplification of analyte binding vents on single beads in single wells yields low background signals, and can increase assay sensitivities up to several orders of magnitude over conventional assays. Biomarker assays run on this platform frequently exhibit sensitivities in the low to mid fg/ml range.
In combination with the markedly heightened sensitivities of these assays, the instrument’s capacity for digital measurement at low concentrations of target analyte and analog measurement at higher analyte concentrations ensures accuracy and precision across a wide dynamic range (> 4 logs) minimizing sample volume requirements and the need for multiple dilutions. Allowing quantification of biomarkers at unprecedented levels in serum, plasma, and additional matrices, PBL’s Simoa-based Assay Services yield robust and reproducible data enabling scientists to attain a better understanding of the contributions of difficult to measure analytes to biological and pathological responses.
Powered by SimoaTM (Single Molecule Array) Technology, Quanterix, Lexington, MA, USA.
NF-light® is a registered trademark of Uman Diagnostics, Umeå Sweden.
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PBL works hand in hand with researchers to help solve difficult assay development and protein quantification problems. Known as a trusted source for high quality, high sensitivity ELISAs as well as interferon proteins and antibodies, PBL employs state-of-the-art technology in conducting assay services and manufacturing world-class products for scientists around the globe. Let us help you solve your most difficult problems... read more
Quick Search
PBL’s improved site search function is defaulted to an exact match.
Search Term Results |
|
IFN beta |
All interferon beta products and related technical information (e.g. technical notes) |
Human IFN beta |
All human interferon products related technical information (e.g. technical notes) |
IL-2 |
All products contain the term “IL-2”, including IL-23 |
IL 2 |
All products contain the term “IL 2”, including IL-23 |
Erythropoietin |
All EPO products and technical information |
Eryth |
All EPO products and technical information |
The results are displayed in best match products grouped in the following product category filters:
Each filter contains sub-categories for further narrowing of your search results
Other web content such as technical notes that contain the Search Term can be displayed by checking the box next to the corresponding filter on the left side of the Search Results Page.