Simoa Assay Services: Ultra-Sensitive Biomarker Testing
Advantages of Simoa Assay Services:
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Utilizing Single Molecule Array technology to deliver femtogram per milliliter (fg/ml) level sensitivity for measurement of low-abundance biomarkers in serum, plasma and other matrices
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Unique immunoassay technology provides robust detection for various single analytes and select multiplex panel options
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High precision service offers accurate and reproducible data with < 10% inter- and intra-assay CVs
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Over 50 analytes available including IL-17A, TNF-alpha, IL-23, IP-10, TRAIL, IL-6, IL-10 and IL-12p70
For an overview of the ultra-sensitive biomarker detection technology, click here.
For additional information, please see the Ultra-Sensitive Biomarker Services Flyer.
Available Human Simoa Immunoassays:
| 3-Plex A TNF-α, IL-6, IL-10 |
3-Plex B TNF-α, IL-6, IL-17A |
Neurology 3-Plex A Aβ-40, Aβ-42, Tau |
α-Synuclein Alpha-Synuclein Assay |
Aβ-40 Amyloid Beta-40 Assay |
Aβ-42 Amyloid Beta-42 Assay |
| BDNF Brain Derived Neurotrophic Factor Assay |
c-MET c-MET Assay |
C-peptide Connecting Peptide Assay |
CA-125 CA-125 Assay |
Cathepsin S Cathepsin S Assay |
Eotaxin Eotaxin Assay |
| GFAP™ Glial Fibrillary Acidic Protein Assay |
G-CSF Granulocyte Colony Stimulating Factor Assay |
GM-CSF Granulocyte Macrophage Colony Stimulating Factor Assay |
IFN-γ Interferon Gamma Assay |
IL-1α Interleukin 1 Alpha Assay |
IL-1β Interleukin 1 Beta Assay |
| IL-2 Interleukin 2 Assay |
IL-3 Interleukin 3 Assay |
IL-4 Interleukin 4 Assay |
IL-5 Interleukin 5 Assay |
IL-6 Interleukin 6 Assay |
IL-7 Interleukin 7 Assay |
| IL-8 Interleukin 8 Assay |
IL-10 Interleukin 10 Assay |
IL-12p40/IL-23 Interleukin 12, p40 Assay |
IL-12p70 Interleukin 12, p70 Assay |
IL-13 Interleukin 13 Assay |
IL-15 Interleukin 15 Assay |
| IL-16 Interleukin 16 Assay |
IL-17A Interleukin 17A Assay |
IL-22 Interleukin 22 Assay |
IL-23 Interleukin 23 Assay |
IL-28A Interleukin 28A Assay |
IL-33 Interleukin 33 Assay |
| IL-36β Interleukin 36 Beta Assay |
IP-10 Interferon Gamma Inducible Protein 10 Assay |
Leptin Leptin Assay |
LIF Leukemia Inhibitory Factor Assay |
MCP-1 Monocyte Chemoattractant Protein-1 Assay |
NF-LIGHT® Neurofilament Light Assay |
| NSE Neuron-Specific Enolase Assay |
p24 Gag Protein p24 Assay |
p-Tau231 Phospho-Tau231 Assay |
PIGF Placental Growth Factor Assay |
PSA Prostate Specific Antigen Assay |
Tau Total Tau Assay |
| TDP43 TAR DNA Binding Protein Assay |
TGF-α Transforming Growth Factor Alpha Assay |
TGF-β Transforming Growth Factor Beta Assay |
TNF-α Tumor Necrosis Factor Alpha Assay |
TNF-β Tumor Necrosis Factor Beta Assay |
TRAIL TNF-related Apoptosis-Inducing Ligand Assay |
| Troponin-I Cardiac Troponin-I (cTnI) Assay |
UCH-L1™ Ubiquitin Carboxyl-Terminal Hydrolase L1 Assay |
VEGF Vascular Endothelial Growth Factor Assay |
Available Mouse Simoa Immunoassays:
| IL-6 Interleukin 6 Assay |
IL-17A Interleukin 17A Assay |
IL-17A/F Interleukin 17A/F Assay |
IL-17F Interleukin 17F Assay |
IL-22 Interleukin 22 Assay |
IL-23 Interleukin 23 Assay |
| Tau Tau Assay |
TNF-α Tumor Necrosis Factor Alpha Assay |
PBL's Ultrasensitive Biomarker Testing Assay Services take advantage of the benefits of Single Molecule Array (Simoa) technology. This approach traps a single bead in low femtoliter-sized wells to allow “digital” measurement of each bead for the presence of analyte in a sandwich immunoassay. The enzymatic amplification of analyte binding vents on single beads in single wells yields low background signals, and can increase assay sensitivities up to several orders of magnitude over conventional assays. Biomarker assays run on this platform frequently exhibit sensitivities in the low to mid fg/ml range.
In combination with the markedly heightened sensitivities of these assays, the instrument’s capacity for digital measurement at low concentrations of target analyte and analog measurement at higher analyte concentrations ensures accuracy and precision across a wide dynamic range (> 4 logs) minimizing sample volume requirements and the need for multiple dilutions. Allowing quantification of biomarkers at unprecedented levels in serum, plasma, and additional matrices, PBL’s Simoa-based Assay Services yield robust and reproducible data enabling scientists to attain a better understanding of the contributions of difficult to measure analytes to biological and pathological responses.
Powered by SimoaTM (Single Molecule Array) Technology, Quanterix, Lexington, MA, USA.
NF-light® is a registered trademark of Uman Diagnostics, Umeå Sweden.
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Digital measurements are independent of intensity and simply rely on a signal/no signal readout on individual microbeads.
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