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41415 Protocol B

41415 Protocol B

VeriKine-HS Human IFN-Beta ELISA Product Flyer

Allows accurate Human IFN-β measurement to as low as 1.2 pg/ml in human serum, plasma, autoimmune disease sera or cell culture media

41415 Product Notice

41415 Product Notice

41415 SDS

41415 SDS

Serum soluble IFNAR2 levels in autoimmune diseases suggest that chronic IFN signaling leads to elevated levels of sIFNAR2

Data from Healthy donors, Systemic Lupus patients, Rheumatoid Arthritis patients, Sjogren's patients, and Scleroderma patients were analyzed

IFN-Beta Therapy increases concentratoin of sIFNAR in MS patient Serum

Results expand upon previous literature which suggests that the mRNA encoding a soluble form of the IFN receptor is increased by long term IFN-beta therapy.

Antiviral Activity of IFN-Alpha Subtypes on Different Cell Lines

The antiviral effect of multiple human and mouse IFN-Alpha subtypes in cell lines derrived from hansters, rats, rhesus, and cynomolgus monkeys were examined

Biological Activities and Detection of Cynomolgus IFN-Alpha Subtypes

Twelve unique Cynomolgus IFN-Alpha proteins were identified, sequenced, cloned and expressed. An ELISA has been developed for the detection of Cynomolgus IFN-Alpha 2 protein.

Binding and Neutralization of Monoclonal Antibodies to Human IFN-Alpha Subtypes

Binding to the IFN-Alpha subtypes was determined by Direct ELISA, IFNAR2 binding, and Sandwich ELISA. Neutralization was determined by ISG-15 based reporter gene assay and CPE in the A549/EMCV system.

Antiviral Activity of Cytokines

This study demonstrates that cytokines which lead to protection from viral challengein A549 cells work primarily through priming the cells to produce IFN-beta upon viral challenge

VeriKine Mouse IFN Alpha ELISA Kit Use with Tissue Homogenates

Technical Note 42120

L-7494

L-7494