Mouse Interferon Alpha All-Subtype Neutralizing Viral Protein
Catalog Number: 12185
- C12R IFN Antagonist neutralizes All 14 Mouse IFN-Alpha subtypes, plus Mouse Limitin, Mouse IFN-Kappa, and Rat IFN-Alpha 1.
- Also suitable for Western Blot.
$310.00
Product Info
| Tested Applications |
|
|---|---|
| Specificity |
Neutralizes:
Does not neutralize the following when tested at ≥100X the typical neutralizing dose
|
| Activity (EC50) | 0.3 - 11.5 ng/ml (varies by subtype) |
Specifications
| Formulation | Supplied frozen in phosphate-buffered saline (PBS) containing 0.1% Bovine Serum Albumin (BSA) |
|---|---|
| Molecular Weight | 32 kDa |
| Purity | > 95% by SDS-PAGE stained by Coomassie Blue Endotoxin level < 1 EU/μg |
| Bioactivity | Measured by neutralization of interferon in a cytopathic effect inhibition assay. |
| Storage | For retention of full activity store at -70°C or below and avoid repeated freeze/thaw cycles |
Tech Info & Data
Background
C12R is an interferon binding/blocking protein produced by many strains of Mousepox (Ectromelia) virus, (Smith and Alcami, J.Vir. 2002, 76:1124). This protein blocks the activity of mouse IFN-Alpha but not Beta. It is an essential protein for viral infection (Xu et al. JEM 2008 205:981).
Citations
1 Citation:
- Lee, S. et al., (2019), "A Secreted Viral Nonstructural Protein Determines Intestinal Norovirus Pathogenesis", Cell Host Microbe. 25(6):845, PMID: 31130511, DOI: 10.1016/j.chom.2019.04.005 (link)