Mouse IFN Alpha 13

Product Features: 
  • Recombinant Mouse IFN Alpha 13 protein expressed in E.coli
  • Member of the Mouse IFN alpha family which may be constitutively expressed and thus have different expression criteria than other subtypes
     

Ordering

Catalog No. Pack Size Price Quantity
12130-1

1 x 105 units

$375.00

Specifications

Formulation Supplied frozen in phosphate-buffered saline (PBS) containing 0.1% Bovine Serum Albumin (BSA)
Molecular Weight 19.1 kDa
Source cDNA obtained from mouse leukocyte interferon expressed in E.coli
Purity > 95% by SDS-PAGE stained by Coomassie Blue
Endotoxin level < 1 EU/μg
Bioactivity Measured using a cytopathic inhibition assay on Mouse (L929) cells with EMCV.
The EC50 for IFN in this assay is ~ 5 U/ml.
Storage For retention of full activity store at -70°C or below and avoid repeated freeze/thaw cycles
Synonyms Mu IFN-α13, Mouse IFN Alpha Subtype, Mouse IFN Protein Subtype, Interferon Alpha, IFN Alpha, IFN-a, Type I IFN Alpha
Accession Number AY220461

Tech Info / Data

Background: 

Mouse IFN Alpha 13 was recently cloned from cells infected with Theiler's virus [van Pesch and Michiels (2003) J. Biol. Chem., 278(47):46321] and from genomic DNA [Hardy et al. (2004) Genomics 84(2):331]. Van Pesch and Michiels had suggested that Mouse IFN Alpha 13 is expressed constitutively in L929 cells. They have also shown that priming of the cells with IFN alpha/beta leads to a decrease in this transcript.

Summary: Mouse IFN alpha 13 is a new interferon which may be constitutively expressed and thus have different expression criteria than other Mu IFN alpha subtypes.

For more information on Mouse IFN Alpha subtype nomenclature click here.

Citations

Comparison of Mouse IFN Alpha 13 and Mouse IFN Alpha A Antiviral Activity

12130-1 Mouse IFN Alpha 13

The activity of Mouse IFN Alpha 13 and Mouse IFN Alpha A was compared in an L929/EMCV CPE assay. The EC50 of Mouse IFN Alpha 13 was 206 pg/ml.

Results are representative and may vary depending upon experimental conditions.

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