Mouse IFN Alpha 13
Specifications
| Formulation | Supplied frozen in phosphate-buffered saline (PBS) containing 0.1% Bovine Serum Albumin (BSA) |
| Molecular Weight | 19.1 kDa |
| Source | cDNA obtained from mouse leukocyte interferon expressed in E.coli |
| Purity | > 95% by SDS-PAGE stained by Coomassie Blue Endotoxin level < 1 EU/μg |
| Bioactivity | Measured using a cytopathic inhibition assay on Mouse (L929) cells with EMCV. The EC50 for IFN in this assay is ~ 5 U/ml. |
| Storage | For retention of full activity store at -70°C or below and avoid repeated freeze/thaw cycles |
| Synonyms | Mu IFN-α13, Mouse IFN Alpha Subtype, Mouse IFN Protein Subtype, Interferon Alpha, IFN Alpha, IFN-a, Type I IFN Alpha |
| Accession Number | AY220461 |
Tech Info / Data
Mouse IFN Alpha 13 was recently cloned from cells infected with Theiler's virus [van Pesch and Michiels (2003) J. Biol. Chem., 278(47):46321] and from genomic DNA [Hardy et al. (2004) Genomics 84(2):331]. Van Pesch and Michiels had suggested that Mouse IFN Alpha 13 is expressed constitutively in L929 cells. They have also shown that priming of the cells with IFN alpha/beta leads to a decrease in this transcript.
Summary: Mouse IFN alpha 13 is a new interferon which may be constitutively expressed and thus have different expression criteria than other Mu IFN alpha subtypes.
For more information on Mouse IFN Alpha subtype nomenclature click here.
Citations
Documentation
Comparison of Mouse IFN Alpha 13 and Mouse IFN Alpha A Antiviral Activity
The activity of Mouse IFN Alpha 13 and Mouse IFN Alpha A was compared in an L929/EMCV CPE assay. The EC50 of Mouse IFN Alpha 13 was 206 pg/ml.
Results are representative and may vary depending upon experimental conditions.
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